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New Study Shows Even Moderate Alcohol Consumption Can Harm People with HIV

February 2, 2016

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New Study Shows Moderate Alcohol Consumption Can Harm People with HIV

A newly published study from Yale University shows that moderate alcohol consumption is more harmful to people with HIV than uninfected individuals, raising the risk of both mortality and other negative health effects. The Yale study is the first to demonstrate the increased harm among patients who have suppressed HIV with modern antiretroviral treatment (ART). […]

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Biochemists Identify Another Piece of the Parkinson’s Disease Pathology Puzzle

January 28, 2016

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Researchers Identify another Piece in the Parkinson's Disease Pathology Puzzle

An international team has discovered that the LRRK2 kinase regulates cellular trafficking by deactivating Rab proteins. This finding illuminates a novel route for therapeutic development and may accelerate testing of LRRK2 inhibitors as a disease-modifying therapy for Parkinson’s, the second most common neurodegenerative disease. An international public-private research consortium has identified and validated a cellular […]

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Yale Researchers Identify Molecular Link between Obesity and Fatty Liver Disease

January 26, 2016

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New Link between Obesity and a Common Liver Disease Discovered

The high levels of obesity in the United States contribute to fatty liver disease, the most common form of liver disease. A newly published study from Yale University identifies molecular links between the two, and points to a possible therapy. Fatty liver disease — also known as nonalcoholic steatohepatitis or NASH — frequently progresses to […]

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New Yale Study Links Childbearing to Accelerated Aging

January 20, 2016

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New Yale Study Links Childbearing to Accelerated Aging

New research from Yale University reveals the first evidence that childbearing may cause accelerated aging in women. The researchers tested 100 healthy postmenopausal women from five rural villages in southern Poland for biomarkers associated with accelerated aging. The study, conducted in partnership with researchers from Jagiellonian University Medical College in Krakow and the Polish Academy […]

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Yale Examines How Bacteria Might Trigger and Treat Autoimmune Disease

January 11, 2016

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How Beneficial Bacteria Inside Our Bodies Might Trigger and Treat Autoimmune Disease

New research from Yale University is exploring how beneficial bacteria that live in the gut might trick the body into an autoimmune reaction known as antiphospholipid syndrome. Doctors often describe the body’s immune system in military terms. Physical barriers such as skin and mucus prevent invasion by disease-causing pathogens such as bacteria and viruses. If […]

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Yale Study Reveals Toxins in Fracking Fluids and Wastewater

January 6, 2016

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Study Reveals Toxins in Fracking Fluids and Wastewater

New research from the Yale School of Public Health analyzed more than 1,000 chemicals in fluids used in and created by hydraulic fracturing (fracking), finding that many of the substances have been linked to reproductive and developmental health problems. Further exposure and epidemiological studies are urgently needed to evaluate potential threats to human health from […]

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Immune Therapy Drug Prolongs Survival in Advanced Lung Cancer Patients

December 21, 2015

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Immune Therapy Drug Shows Promise in Fight Against Cancer

A newly published study involving patients with advanced non-small cell lung cancer resistant to chemotherapy has found a promising weapon in an immune therapy drug commonly used to treat other cancers. The findings were published December 19 in The Lancet and presented at the 2015 annual conference of the European Society for Medical Oncology in […]

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New Research Reveals How Cancer Cells Escape Blood Vessels

December 16, 2015

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Scientists Reveal How Cancer Cells Escape Blood Vessels

A newly published study from MIT and Massachusetts General Hospital reveals how cancer cells latch onto blood vessels and invade tissues to form new tumors — a finding that could help researchers develop drugs that inhibit this process and prevent cancers from metastasizing. Cancer cells circulating in the bloodstream can stick to blood vessel walls […]

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Hospital Price Study Reveals ‘Mind-Boggling’ Variation Across USA

December 16, 2015

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Hospital Prices Show Mind-Boggling Variation Across USA

A new study from Yale University economists reveals that the prices hospitals negotiate with health insurance companies vary enormously within and across geographic regions in the United States. For example, the study shows that in 2011 hospital prices for lower-limb MRIs were 12 times higher in the most expensive region of the United States (Bronx, […]

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Yale Researchers Discover New Complexities Behind Drug Resistance

December 10, 2015

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New Study Probes Genes for Clues to Drug Resistance in Aggressive Breast Cancer

New research from Yale University probes genes for clues to drug resistance in aggressive breast cancer. By sifting through the 20,000 protein-encoding genes in the human genome, Yale researchers discovered new complexities behind drug resistance and identified patterns of mutations that could predict which therapies will benefit patients with aggressive breast cancer. The findings will […]

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Scientists Develop a New Way to Deliver MicroRNAs for Cancer Treatment

December 8, 2015

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Researchers Develop a New Way to Deliver MicroRNAs

By twisting RNA strands into a triple helix and embedding them in a biocompatible gel, researchers from MIT have developed a new way to shrink tumors in mice with an aggressive form of breast cancer. Twenty years ago, scientists discovered that short strands of RNA known as microRNA help cells to fine-tune their gene expression. […]

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New Strategy to Better Protect Cancer Patients from the Flu

December 7, 2015

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New Vaccine Better Protects Cancer Patients from Flu

Scientists from Yale University have developed a new vaccine strategy that reduces the risk of flu infections in cancer patients at highest risk for influenza. The findings were presented December 6 at the 57th annual meeting of the American Society of Hematology in Orlando, Florida. Patients with cancers of the immune system, like multiple myeloma, […]

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MRI May Lead to Overdiagnosis of Cancer

December 2, 2015

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MRI May Lead to Overdiagnosis of Cancer for Older Women

New research from Yale University details how magnetic resonance imaging (MRI) for many women undergoing breast cancer surgery might identify health problems that would not otherwise impact patients — or lead to “overdiagnosis.” Published in the Journal of Clinical Oncology, the study examined whether preoperative MRI use would allow doctors to identify breast cancer in […]

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Yale Study Shows Enhanced Treatment for Hepatitis C Could Cut Prevalence by 80%

December 1, 2015

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New Treatment for Hepatitis C Could Cut Prevalence by 80%

New research from Yale University shows that novel antiviral therapies for hepatitis C could reduce the prevalence of the blood-borne infection by more than 80%. The finding raises the possibility of greatly reducing, and even eliminating, hepatitis C in the United States if enhanced screening and treatment efforts target high-risk populations. The study published online […]

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Experimental Alzheimer’s Drug J147 Shows Anti-Aging Effects

November 13, 2015

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Experimental Alzheimer's Drug Shows Anti-Aging Effects

New research from the Salk Institute shows that the experimental Alzheimer’s drug J147 has a host of unexpected anti-aging effects in animals. The Salk team expanded upon their previous development of a drug candidate, called J147, which takes a different tack by targeting Alzheimer’s major risk factor–old age. In the new work, the team showed […]

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Study Shows Diabetes Drug Significantly Reduces Risk of Heart Failure

November 10, 2015

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Diabetes Drug Reduces Risk of Heart Failure

A new clinical trial has shown that a type 2 diabetes drug significantly reduces hospitalizations and death from heart failure. The findings, from a large clinical trial known as EMPA-REG OUTCOME, were presented by Yale professor of medicine and clinical chief of endocrinology, Dr. Silvio E. Inzucchi, at the 2015 American Heart Association (AHA) Scientific […]

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A New Paradigm for Cancer Research, One That Focuses on Improving Efficacy and Value

November 5, 2015

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A New Paradigm for Cancer Research

A newly published study from Yale University tackles the issue of value in cancer research, recommending a new paradigm for research that focuses on improving efficacy and value, as well as ensuring population health impact and generating new knowledge. The $100 billion federal government investment in the “War on Cancer,” has produced only relatively modest […]

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Harvard Studies Show Improvements in U.S. Diet Lower Premature Deaths

November 4, 2015

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New Studies Shed Light on Critical Dietary Issues Facing Americans

Two newly published studies from the Harvard T.H. Chan School of Public Health shed light on critical dietary issues facing Americans. The first study showed that while recent improvements in the U.S. diet have helped reduce disease and premature death, the overall American diet is still poor. The second study, which analyzed interventions to reduce […]

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