Alzheimer’s News

Common Mechanism May Be Responsible for the Spread of Alzheimer’s and CTE

December 8, 2016

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Alzheimer’s and CTE May Spread Via a Common Mechanism

A newly published study from UC San Francisco reveals that a shared biological mechanism may drive the progression of both Alzheimer’s disease and chronic traumatic encephalopathy. Both Alzheimer’s and CTE are classified as “tauopathies,” a category of diseases characterized by the improper folding and clumping together of a protein called tau (rhymes with “how”) inside […]

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STEP Protein Linked to Alzheimer’s May Also Play a Role in Schizophrenia

October 18, 2016

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Protein linked to Alzheimer’s May Also Play a Role in Schizophrenia

New research from Yale University shows that an increase in the STEP (STriatal-Enriched protein tyrosine Phosphatase) protein leads to a disruption of synaptic function and contributes to cognitive disorders. A specific protein implicated in the cognitive decline of Alzheimer’s disease also appears to play a role in genetic predisposition to schizophrenia, meaning that a drug […]

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New Study Shows Fructose Alters Brain Genes, Which Can Lead to Disease

April 25, 2016

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New Research Shows Fructose Alters Brain Genes, Can Lead to Disease

A new study by researchers at UCLA reveals that genes in the brain can be damaged by fructose, leading to diseases like diabetes, cardiovascular disease, Alzheimer’s disease and attention deficit hyperactivity disorder. A range of diseases — from diabetes to cardiovascular disease, and from Alzheimer’s disease to attention deficit hyperactivity disorder — are linked to […]

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New Research Shows Hyperactive Neurons May Trigger Alzheimer’s

January 13, 2016

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Hyperactive neurons may be culprit in Alzheimer’s

New research from Yale University shows that an increase in neuronal activity can spur the creation of plaques and toxic amyloid beta peptides, which are believed to trigger Alzheimer’s disease. A long-term reduction in neuronal activity reduces amyloid plaques associated with Alzheimer’s disease, Yale University researchers have found. The study, using mouse models of Alzheimer’s, […]

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Experimental Alzheimer’s Drug J147 Shows Anti-Aging Effects

November 13, 2015

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Experimental Alzheimer's Drug Shows Anti-Aging Effects

New research from the Salk Institute shows that the experimental Alzheimer’s drug J147 has a host of unexpected anti-aging effects in animals. The Salk team expanded upon their previous development of a drug candidate, called J147, which takes a different tack by targeting Alzheimer’s major risk factor–old age. In the new work, the team showed […]

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Enhanced-Sensitivity NMR Reveals New Details on Protein Structure

October 8, 2015

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MIT Researchers Reveal New Clues to How Proteins Fold

Using a new technique based on dynamic nuclear polarization, scientists hope to gain more insight into protein structure and function. Proteins can fold in different ways depending on their environment. These different configurations change the function of the protein; misfolding is frequently associated with diseases such as Alzheimer’s and Parkinson’s. Until now, it has been […]

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Yeast Protein Reveals Clues to How Alzheimer’s Forms

September 25, 2015

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Yeast Protein Offers Clues to How Alzheimer’s Disease Begins

In a newly published study, biologists from MIT detail how a yeast protein may lead to anti-amyloid therapeutic opportunities. Fibrous protein clumps known as amyloids are most often associated with diseases such as Alzheimer’s disease, where they form characteristic plaques in the brain. Scientists first described amyloids about 150 years ago; they have since been […]

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Scientists Report a Major Breakthrough in Alzheimer’s Disease

September 20, 2015

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Researchers Report a Major Breakthrough in Alzheimer's Disease

New research sheds light on a fundamental mechanism underlying the development of Alzheimer’s disease and could lead to new forms of therapy people with the disease. Alzheimer’s is the most common form of dementia globally and affects up to 40,000 people in Ireland today. It is the fourth leading cause of death in individuals over […]

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Lysosomes May Contribute to Alzheimer’s Disease

June 30, 2015

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Lysosomes May Contribute to Alzheimer's

New research from Yale University shows lysosomes, the “garbage disposal” systems of cells, can fail and perhaps contribute to Alzheimer’s disease. Lysosomes, the “garbage disposal” systems of cells, are found in great abundance near the amyloid plaques in the brain that are a hallmark of Alzheimer’s disease. Scientists have long assumed that their presence was […]

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Study Shows Poor Sleep Linked to Alzheimer’s Disease

June 3, 2015

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Poor Sleep Linked to Alzheimer’s and Memory Loss

A newly published study from UC Berkeley reveals a new pathway through which Alzheimer’s disease may cause memory decline later in life. UC Berkeley scientists have found compelling evidence that poor sleep — particularly a deficit of the deep, restorative slumber needed to hit the save button on memories — is a channel through which […]

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AZD05030 Restores Memory and Synapse Loss in Alzheimer Mice

April 2, 2015

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Experimental Cancer Drug Restores Memory

New research from Yale University reveals that the experimental cancer drug AZD05030 blocks damage triggered during the formation of amyloid-beta plaques, restoring synaptic connections and memory in a mouse model of Alzheimer’s. Memory and as well as connections between brain cells were restored in mice with a model of Alzheimer’s given an experimental cancer drug, […]

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New MIND Diet May Significantly Lower Risk of Alzheimer’s Disease

March 23, 2015

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MIND Diet May Significantly Protect Against Alzheimer’s Disease

New research from Rush University Medical Center shows that the MIND diet could significantly lower a person’s risk of developing Alzheimer’s disease. A new diet, appropriately known by the acronym MIND, could significantly lower a person’s risk of developing Alzheimer’s disease, even if the diet is not meticulously followed, according to a paper published online […]

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Yale Research Shows Immune Cells Are an Ally, Not Enemy, in Battle Against Alzheimer’s

January 29, 2015

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Study Shows Immune Cells Are An Ally Against Alzheimer’s

New research in battle against Alzheimer’s shows that brain immune cells (called microglia) seem to protect the brain by keeping amyloid plaques corralled, and are not re responsible for inflammation and damage to surrounding brain cells as previously thought. Beta-amyloid is a sticky protein that aggregates and forms small plaques in the brains of the […]

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New Non-Invasive MRI Technology Detects Alzheimer’s Disease Early

December 23, 2014

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New Non-Invasive Method Can Detect Alzheimer’s Disease Early

A newly published study details how a new MRI probe that pairs a magnetic nanostructure with an antibody can detect Alzheimer’s disease early. Evanston, Illinois — No methods currently exist for the early detection of Alzheimer’s disease, which affects one out of nine people over the age of 65. Now, an interdisciplinary team of Northwestern […]

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Proper Copper Levels Essential to Spontaneous Neural Activity

December 2, 2014

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Proper Copper Levels Essential to Spontaneous Neural Activity

A new study from the Berkeley Lab reveals that proper copper levels are essential to the health of a brain at rest and suggests that mismanagement of copper in the brain linked to Alzheimer’s and other neurological disorders can also contribute to misregulation of signaling in cell−to-cell communications. In recent years it has been established […]

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Noninvasive Arterial Spin Labeling MRI Detects Evidence of Cognitive Decline Before Symptoms Appear

October 8, 2014

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New MRI Technique Detects Evidence of Cognitive Decline

A new study shows that a noninvasive arterial spin labeling MRI can detect signs of cognitive decline in the brain even before symptoms appear, finding that patients who showed reduced brain perfusion at their initial exams exhibited cognitive decline at follow-up 18 months later. Oak Brook, Illinois — A magnetic resonance imaging (MRI) technique can […]

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New Drug Compound Reverses the Brain Deficits of Alzheimer’s Disease in Mice

August 6, 2014

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Researchers Reversed the Effects of Alzheimers Disease in Mice

A newly published study reveals a new drug compound that inhibits the negative effects of a protein called STtriatal-Enriched tyrosine Phosphatase and reverses the brain deficits of Alzheimer’s disease in mice. Researchers at Yale School of Medicine have discovered a new drug compound that reverses the brain deficits of Alzheimer’s disease in an animal model. […]

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Scientists Confirm Cellular Basis for Memory by Implanting and Erasing Fear in Rats

June 2, 2014

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Researchers Confirm Cellular Basis for Memory by Implanting and Erasing Fear

In a newly published study, scientists at the University of California show the ability to selectively remove a memory and predictably reactivate it by stimulating nerves in the brain at frequencies that are known to weaken and strengthen the connections between nerve cells. Researchers at the University of California, San Diego School of Medicine have […]

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