Newly published research from biochemists at the University of North Carolina School of Medicine describes how a protein that is required for DNA replication, Cdt1, also plays an important role in mitosis. Chapel Hill, North Carolina – The foundation of biological inheritance is DNA replication – a tightly coordinated process in which DNA is simultaneously [...]

A new study from MIT shows that staggering the delivery of cancer drugs is far more effective than administering them at the same time. The research team found the using erlotinib between four and 48 hours before doxorubicin dramatically increased cancer-cell death, killing up to 50 percent of triple-negative cells. Doctors have long known that [...]

A new study describes how a team of researchers are exploring ways to manipulate the body’s existing T cells that normally kill viruses and redirect them to kill cancer cells instead. By engineering a new class of drugs called ImmTACs, they were able to show that ImmTAC could, potentially, result in the regression of established [...]

New research points that there could be a single drug that could shrink or cure all types of cancer, whether it’s breast, ovary, colon, bladder, brain, or liver. The treatment uses an antibody that blocks the ‘do not eat’ signal that’s usually displayed on tumor cells and coaxes the immune system to destroy cancer cells. [...]

The cancer drug, BIND-014, is the first targeted and programmed nanomedicine to enter human clinical studies. A newly published study demonstrate BIND-014’s ability to effectively target a receptor expressed in tumors to achieve high tumor drug concentrations and could potentially revolutionize how diseases such as cancer are treated. A team of scientists, engineers and physicians [...]

A new vaccine has been found to extend the life of patients suffering from recurrent glioblastoma multiforme. A phase 2 clinical trial showed that by using material from the patient’s own tumor, neurologists were able to tailor a vaccine that could extend survival when compared to standard therapy techniques. A new brain cancer vaccine tailored [...]

Technological advances in the field of neutron generators are being made at Sandia National Laboratory. By thinking outside the box, scientists have come up with a computer chip-shaped neutron source that is inexpensive and may have commercial uses including treating cancer patients from home instead of at the hospital. ALBUQUERQUE, New Mexico — It was [...]

A newly published research study from the UNC Lineberger Comprehensive Cancer Center describes how the absence of the protein NLRP12 significantly increases susceptibility to colitis-associated colon cancer in pre-clinical models. CHAPEL HILL, North Carolina – A family of proteins is yielding new information about how it contributes to the development of gastrointestinal disease and cancer. [...]

A new study suggests that dosage size matters when it comes to treating cancer with angiogenesis inhibitors and nanomedicines. Scientists at the Harvard School of Engineering and Applied Sciences and Massachusetts General Hospital discovered that vascular normalization only increases the delivery of the smallest nanomedicines to cancer cells and showed that the smallest nanomedicines are [...]

Findings suggest that our own immune system may be working against us when it comes to protection from skin cancer. The scientists found that in patients whose tumors expressed B7-H1, an immune-inhibiting molecule in melanoma, suppression of the inflammatory immune response promoted the growth and aggressiveness of their melanoma tumors. A new study by researchers [...]

Authored by leading scientists at top institutions, the Cancer Cell Line Encyclopedia (CCLE) is a resource that joins deeply detailed cancer genome data with predictors of drug response, information that could lead to refinements in cancer clinical trials and future treatments. The goal of cancer treatment is to match the right drug to the right [...]

Zelboraf, which targets the mutated BRAF gene, is used to treat melanoma, but it isn’t always successful due to melanoma’s ability to sometimes get around the inhibitor. Now, scientists have a better idea of the mechanism behind the melanoma resistance. By examining the exome, researchers found that the mutated BRAF gene driving the cancer becomes [...]