Cancer News

A Promising New Form of Immunotherapy for Cancer

October 27, 2016

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New Approach to Cancer Treatment

New research suggests a way to increase the staying power of CAR T cells, a promising form of immunotherapy for cancer. In people with chronic infections or cancer, disease-fighting T cells tend to behave like an overworked militia — wheezing, ill-prepared, tentative, in a state of “exhaustion” that allows disease to persist. In a paper […]

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Two-Pronged Immune Response Destroys Tumors

October 24, 2016

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New Treatment Elicits Two-Pronged Immune Response That Destroys Tumors in Mice

Using a combination of four different therapies, researchers from MIT reveal a new treatment that destroys tumors in mice. Harnessing the body’s own immune system to destroy tumors is a tantalizing prospect that has yet to realize its full potential. However, a new advance from MIT may bring this strategy, known as cancer immunotherapy, closer […]

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New Study Shows Resistance to Cancer Drugs Runs Deeper Than a Single Gene

October 20, 2016

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Resistance to Cancer Drugs Runs Deeper Than a Single Gene

A new study from Yale University shows that resistance to cancer drugs runs deeper than a single gene. Searching for more individual genes to predict responses to breast cancer therapy may not work, a new study suggests. Instead, scientists and clinicians need to pay attention to abnormalities in networks of genes, Yale researchers report in […]

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Yale Researchers Reveal Genes Behind Aggressive Ovarian and Endometrial Cancers

October 11, 2016

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Researchers Find Genes Behind Aggressive Ovarian and Endometrial Cancers

Researchers from Yale University have defined the genetic landscape of rare, highly aggressive tumors called carcinosarcomas, pointing the way to possible new treatments. The findings are published in the early edition of Proceedings of the National Academy of Sciences. Endometrial and ovarian cancers are the most prevalent gynecologic tumors in women, with over 76,160 newly […]

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Researchers Identify a New Way to Suppress Lung Tumors

October 3, 2016

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A New Way to Suppress Lung Tumors

A team of researchers has identified a new blocking mechanism that acts more like a dimmer switch and potently inhibits lung tumor cell growth. Lung cancer cell growth depends on certain proteins that require the addition of sugar molecule chains to become active. Scientists have long thought that the addition of these sugar chains is […]

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MIT Develops Nanosensors That Can Profile Tumors

September 29, 2016

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New Nanosensors Can Profile Tumors

Engineers at MIT have developed new nanosensors that can profile tumors and may yield insight into how they will respond to certain therapies. MIT researchers have designed nanosensors that can profile tumors and may yield insight into how they will respond to certain therapies. The system is based on levels of enzymes called proteases, which […]

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New T Cell Subsets Have Potential to Improve Cellular Therapy for Cancer

September 14, 2016

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Researchers Identify New T cell Subsets with Potential to Improve Cellular Therapy for Cancer

Researchers from the Yale Cancer Center have identified that two genes, NR4A1 and ABC transporters, mark a distinct subset of quiescent T cells within human tissues, and have developed methods to mobilize them into circulation for potential application in adoptive T cell therapy of cancer. The study is published in the Journal of Clinical Investigation. […]

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Adhesive Patch Delivers Therapy to Tumor Sites

August 1, 2016

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New Device Delivers Therapy to Tumor Sites

A newly published study from MIT describes an adhesive patch that can stick to the tumor site, either before or after surgery, to deliver a triple-combination of drug, gene, and photo (light-based) therapy. Approximately one in 20 people will develop colorectal cancer in their lifetime, making it the third-most prevalent form of the disease in […]

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Yale Study Reveals How a Cancer Gene Promotes Tumor Growth

June 27, 2016

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How a Cancer Gene Promotes Tumor Growth

A new discovery by Yale researchers may help lead to individualized treatments for lung cancer and other types of cancer. A Yale-led study describes how a known cancer gene, EGFR, silences genes that typically suppress tumors. The finding, published in Cell Reports, may lead to the development of more effective, individualized treatment for patients with […]

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Yale Study Finds Racial Differences in Smoking Patterns

March 15, 2016

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Study Finds Differences in Smoking Habits between African Americans and Whites

A newly published study from Yale University reveals that differences in smoking habits between African Americans and whites may lead to a disparity in screening for lung cancer. The paper was published online March 15 in Nicotine & Tobacco Research. Cigarette smoking, the leading cause of preventable death in the United States, has been widely […]

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Yale Study Shows Key Protein In Pancreatic Cancer Growth May Also Be Its Undoing

March 14, 2016

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A New Target for Attacking Pancreatic Cancer

In a newly published study, Yale scientists reveal that the overexpression of a protein called renalase in pancreatic cancer plays a critical role in spurring the cancer’s growth while also providing a possible new target for attacking the tumors it helps develop. Pancreatic cancer is one of the deadliest cancers, causing about 40,000 deaths annually […]

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Scientists Reveal Amino Acids Supply Most Building Blocks for Tumor Cells

March 8, 2016

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Amino Acids Supply Most Building Blocks for Tumor Cells

New research shows that amino acids, not glucose, account for the majority of cell mass in proliferating mammalian cells. Cancer cells are notorious for their ability to divide uncontrollably and generate hordes of new tumor cells. Most of the fuel consumed by these rapidly proliferating cells is glucose, a type of sugar. Scientists had believed […]

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MIT Research Shows How Diet Influences Colon Cancer

March 2, 2016

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MIT Study Shows How Diet Influences Colon Cancer

New research from MIT reveals ties high-fat diet to changes in intestinal stem cells, helping to explain an increased cancer risk. Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer. Now, a new study from MIT reveals how a high-fat […]

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Yale Researchers Identify Gene That Regulates the Growth of Melanoma

February 29, 2016

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Yale Identifies Gene That Regulates the Growth of Melanoma

New research from Yale University identifies a gene in melanoma that can dramatically affect the growth of the disease. The findings, published in the journal Cell Reports, provide new insight into how melanoma grows and identifies a new target for treatment of melanoma and other cancers. Enzymes that chemically modify DNA, known as DNA methyltranferases, […]

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Yale Scientists Reveal Underlying Cause of Myeloma

February 11, 2016

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Yale Scientists Discover Underlying Cause of Myeloma

Scientists from the Yale Cancer Center have identified what causes a third of all myelomas, a type of cancer affecting plasma cells. The findings, published February 10 in the New England Journal of Medicine, could fundamentally change the way this cancer and others are treated. Multiple myeloma is a cancer involving the growth of plasma […]

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Immune Therapy Drug Prolongs Survival in Advanced Lung Cancer Patients

December 21, 2015

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Immune Therapy Drug Shows Promise in Fight Against Cancer

A newly published study involving patients with advanced non-small cell lung cancer resistant to chemotherapy has found a promising weapon in an immune therapy drug commonly used to treat other cancers. The findings were published December 19 in The Lancet and presented at the 2015 annual conference of the European Society for Medical Oncology in […]

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New Research Reveals How Cancer Cells Escape Blood Vessels

December 16, 2015

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Scientists Reveal How Cancer Cells Escape Blood Vessels

A newly published study from MIT and Massachusetts General Hospital reveals how cancer cells latch onto blood vessels and invade tissues to form new tumors — a finding that could help researchers develop drugs that inhibit this process and prevent cancers from metastasizing. Cancer cells circulating in the bloodstream can stick to blood vessel walls […]

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Yale Researchers Discover New Complexities Behind Drug Resistance

December 10, 2015

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New Study Probes Genes for Clues to Drug Resistance in Aggressive Breast Cancer

New research from Yale University probes genes for clues to drug resistance in aggressive breast cancer. By sifting through the 20,000 protein-encoding genes in the human genome, Yale researchers discovered new complexities behind drug resistance and identified patterns of mutations that could predict which therapies will benefit patients with aggressive breast cancer. The findings will […]

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