Cancer News

Drug-Resistant EGFR May Have “Achilles Heel”

May 19, 2015

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Two Experimental Drugs Show Promise Against Drug-Resistant EGFR

Researchers from Yale University have discovered a key structural difference in the drug-resistant form of EGFR that could lead to new strategies to combat the disease. Drugs introduced more than a decade ago that target mutations in a protein known as the epidermal growth factor receptor (EGFR) held the promise of personalized treatments for a […]

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Targeting Brain Metastases with Stem Cell Therapy

April 27, 2015

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Targeting Breast to Brain Metastatic Tumor

Researchers have developed an in vivo imageable breast-to-brain metastasis mouse model. Using real time in vivo imaging and subsequent composite fluorescence imaging, they show a widespread distribution of micro- and macro-metastasis in different stages of metastatic progression. Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General Hospital (MGH) have developed an “imageable” mouse model of […]

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Implantable Device Allows Doctors to Identify the Best Chemotherapy Agents

April 24, 2015

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Implantable Device Tests Cancer Drugs in Patients

A team of engineers has developed a new implantable device that will allow doctors to test the effectiveness of cancer drugs and to identify drugs that work best for each patient prior to starting systemic administration of chemotherapy. More than 100 drugs have been approved to treat cancer, but predicting which ones will help a […]

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Ebola-Like Virus Safely Destroys Brain Tumors

April 17, 2015

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Virus Safely Destroys Brain Tumors

New research from Yale University details how scientists used a novel chimeric virus (VSV-LASV-GPC) containing genes from both Lassa and VSV to target and completely destroyed brain cancer without adverse actions within or outside the brain. Brain tumors are notoriously difficult for most drugs to reach, but Yale researchers have found a promising but unlikely […]

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Gold Nanoparticles Intensify Cancer-Killing Radiation

April 16, 2015

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Gold Enhances Radiation Effect on Cancer Cells

Using gold nanoparticles tethered to acid-seeking compounds called pHLIPs, a team of researchers has demonstrated a more precise method for targeting cancer cells with radiation. Providence, Rhode Island (Brown University) — Researchers from Brown University and the University of Rhode Island have demonstrated a promising new way to increase the effectiveness of radiation in killing […]

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New Approach Halts the Growth of a Very Aggressive Form of Melanoma

April 14, 2015

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Stimulating Major Branches of the Immune System Halts Tumor Growth More Effectively

By stimulating both major branches of the immune system, researchers from MIT were able to halt the growth of a very aggressive form of melanoma in mice. The human immune system is poised to spring into action at the first sign of a foreign invader, but it often fails to eliminate tumors that arise from […]

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Study Shows Link between Muscle-Building Supplements and Cancer

April 13, 2015

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Study Shows Cancer Link for Muscle-Building Supplements

New research shows that men taking muscle-building supplements with creatine or androstenedione are more likely to develop testicular cancer. Providence, Rhode Island (Brown University) — Men who reported taking muscle-building supplements, such as pills and powders with creatine or androstenedione, reported a significantly higher likelihood of having developed testicular cancer than men who did not […]

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Biologists Identify Vulnerability in Brain Cancer Cells

April 10, 2015

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Biologists Identify Brain Tumor Weakness

Researchers from MIT and the Whitehead Institute have discovered a vulnerability of brain cancer cells that could offer a new target for treatment of glioblastoma. The study, led by researchers from the Whitehead Institute and MIT’s Koch Institute for Integrative Cancer Research, found that a subset of glioblastoma tumor cells is dependent on a particular […]

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Biologists Map the Habits of Cancer Cells

April 8, 2015

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Scientists Map the Habits of Cancer Cells

Yale University researchers are mapping the habits of cancer cells, determining which cues cause cancer cells to disperse and metastasize, how these cues are combined with other cues directing the invasion, and which cues hold sway when there are conflicting orders. Using advanced technology and an approach that merges engineering and medicine, a Yale University-led […]

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DNA Mutations Can Be Good in Brain Tumors

March 25, 2015

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Possible Personalized Treatments for More Aggressive Forms of Brain Cancer

New research from Yale University reveals that it may be possible to develop personalized treatments for more aggressive forms of brain cancer. DNA mutations can cause cancer but in some cases, more mutations may mean a better prognosis for patients. A Yale-led comprehensive genomic analysis of more than 700 brain tumors has revealed one such […]

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New Nanodevice Defeats Drug Resistance By Turning Off Drug-Resistance Genes

March 4, 2015

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Nanodevice Defeats Drug Resistance

Researchers from MIT have developed a new nanodevice that can defeat drug resistance by turning off the drug resistant gene and then releasing cancer drugs against the disarmed tumors. Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. A new nanodevice developed by MIT researchers […]

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Yale Develops a Faster and Less Expensive Way to Analyze Gene Activity

March 4, 2015

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A Faster and Less Expensive Way to Analyze Gene Activity

A newly published study details a method called modular, early-tagged amplification (META) RNA profiling that can quantify a broad panel of microRNAs or mRNAs simultaneously across many samples and requires far less sequence depth than existing digital profiling technologies. A team of Yale researchers has developed a simple method that could significantly reduce the time […]

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A Real-Time Blood Test for Cancer Tumors

February 27, 2015

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A Real-Time Blood Test for Solid Lung Cancer Tumors

A newly published study from Yale University shows that liquid biopsies offer a real-time blood test for solid lung cancer tumors. In the rapidly changing world of molecular profiling for genetic diseases, cancer researchers are increasingly optimistic about the reality of a simple blood test to monitor and treat solid tumor cancers. Recent studies show […]

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3D Vaccine Spontaneously Assembles to Fight Cancer, Infectious Diseases

February 9, 2015

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3D Vaccine Delays Tumor Growth in Mice

Researchers have developed a new 3D vaccine that spontaneously assembles to provide a more effective way to harness the immune system to fight cancer as well as infectious diseases. The vaccine spontaneously assembles into a scaffold once injected under the skin and is capable of recruiting, housing, and manipulating immune cells to generate a powerful […]

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Ultrasound Can Detect Cancers Missed by Mammography

February 9, 2015

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Untapped Potential for Supplementing Mammography

New research shows that a supplementary screening with ultrasound can detect cancers missed by mammography, and reveals that women with dense breast tissue can benefit from this extra screening. The purpose of screening examinations for breast cancer is to detect tumors before they cause symptoms such as a lump, swelling or redness. Discovering tumors in […]

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How Cancer Uses Notch Signaling to Promote Metastasis

January 29, 2015

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How Cancer Turns Good Cells Bad

A new computational study shows how cancer cells take advantage of the system by which cells communicate with their neighbors as they pass messages to “be like me” or “be not like me.” Cancer uses a little-understood element of cell signaling to hijack the communication process and spread, according to Rice University researchers. Led by […]

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Study Shows Vitamin D Protects Against Colorectal Cancer

January 28, 2015

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Vitamin D Protects Against Colorectal Cancer

A newly published study from the Dana-Farber Cancer Institute reveals that vitamin D can protect some people with colorectal cancer by perking up the immune system’s vigilance against tumor cells. The research, published by the journal Gut, represents the first time that a link between vitamin D and the immune response to cancer has been […]

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