In a newly published study, Yale University researchers show that a fast-acting virus targets most melanoma tumors after injection into the blood stream of mice. Yale researchers eradicated most melanoma tumors by exposing them to a fast-acting virus, they report in the June 15 edition of the Journal of Virology. Melanoma is the deadliest type [...]

New research presented at the 2013 annual meeting of the American Society of Clinical Oncology shows promising results in the fight against advanced melanoma, finding that the combination of two immune stimulating antibodies produced rapid and deep tumor regressions in approximately 30% of patients. Combining two cancer immunotherapy drugs in patients with advanced melanoma produced [...]

Researchers have identified four new genetic variants associated with an increased risk of testicular cancer, supporting the notion that testicular cancer is a disorder of germ cell development and maturation. Philadelphia — A new study looking at the genomes of more than 13,000 men identified four new genetic variants associated with an increased risk of [...]

Scientists have identified a way to flip a genetic switch off to halt tumor growth, demonstrating a potential new therapy in mice that impacts tumor growth in a significant way. Approximately 90 percent of cancers start within tissues that form the inner linings of various organs. Decades of accumulated genetic mutations can, on occasion, induce [...]

In another step forward for personalized medicine, scientists at UCLA have classified kidney cancer into several unique subtypes that will help tailor individual cancer treatment. Researchers with UCLA’s Institute of Urologic Oncology and department of urology have classified kidney cancer into several unique subtypes, a breakthrough that will help physicians tailor treatment to individual kidney [...]

Using nanoscale diamond-like particles called nanodiamonds, researchers have developed a potentially more effective treatment for “triple-negative” breast cancer, notably decreasing tumor growth and eliminating the devastating side effects of cancer treatment during testing with mice. Recently, doctors have begun to categorize breast cancers into four main groups according to the genetic makeup of the cancer [...]

Researchers at the University of Missouri have developed a new form of radiation therapy that successfully put cancer into remission in mice without the harmful side-effects of conventional chemo and radiation cancer therapies. Columbia, Missouri – Cancer painfully ends more than 500,000 lives in the United States each year, according to the Centers for Disease Control [...]

In a new study, a team of scientists have shown that a single antibody shrinks variety of human tumors transplanted into mice, finding that anti-CD47 antibodies can dramatically inhibit the growth of human solid tumors by blocking the ability of CD47 to transmit the ‘don’t-eat-me’ signal to macrophages. Human tumors transplanted into laboratory mice disappeared [...]

In a pre-clinical mouse model, VHIO scientists eliminated lung tumors by inhibiting the protein Myc. Previous studies had already shown that Myc was a key protein in tumor development and had established how to inhibit Myc through gene therapy. This protein is involved in the development of diverse tumors and so Myc-targeted therapy could make [...]

In a newly published study, an international team of scientists has identified a molecular pathway that appears to be essential for the growth and spread of medulloblastoma, the most common malignant brain tumor in children. In their report in the February 28 issue of Cell, they show that blocking this pathway—which involves interactions between tumor [...]

UCLA scientists have developed a NanoVelcro Chip that can detect and isolate single cancer cells from patient blood samples for analysis. Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients’ tumors and circulate in the blood. With the improvements to [...]

A newly published study shows that so-called passenger mutations can slow or even halt tumor growth and suggests that cancer should be viewed as an evolutionary process whose course is determined by a delicate balance between driver-propelled growth and the gradual buildup of passenger mutations. A typical cancer cell has thousands of mutations scattered throughout [...]