Disease News

Study Shows Bacterial Infection, C. dificile, Widespread in the United States

March 9, 2015

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Bacterial Infection Widespread in the United States

Using population-based surveillance data, new research estimates that the germ Clostridium difficile caused nearly half a million infections in the United States in a single year. A new federal study estimates that the germ Clostridium difficile, more commonly known as C. difficile, caused nearly half a million infections in the United States in a single […]

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Possible Signs of Progress in the Fight Against Parkinson’s

March 4, 2015

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Signs of Progress Against Parkinson’s

By using induced pluripotent stem cells, researchers have markedly reduced the symptoms Parkinson’s disease in primates. Harvard Stem Cell Institute (HSCI) researchers at University-affiliated McLean Hospital have taken what they describe as an important step toward using the implantation of stem cell-generated neurons as a treatment for Parkinson’s disease. Ole Isacson and colleagues reported that […]

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Scientists Reverse Type 2 Diabetes and Fatty Liver Disease

March 2, 2015

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Researchers Reverse type 2 Diabetes and Fatty Liver Disease

A newly published study reveals how scientists from Yale University developed a controlled-release oral therapy that reversed type 2 diabetes and fatty liver disease in rats. Existing therapies for type 2 diabetes, and the closely associated conditions of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), have had limited success at treating the root […]

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New Anti-HIV Candidate Blocks Every Strain of HIV-1, HIV-2 and SIV

February 18, 2015

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Scientists Announce New Anti-HIV Agent

In a new study, researchers show that a new drug candidate blocks every strain of HIV-1, HIV-2 and SIV that has been isolated from humans or rhesus macaques, including the hardest-to-stop variants. Jupiter, Florida – February 18, 2015 – In a remarkable new advance against the virus that causes AIDS, scientists from the Jupiter, Florida […]

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3D Vaccine Spontaneously Assembles to Fight Cancer, Infectious Diseases

February 9, 2015

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3D Vaccine Delays Tumor Growth in Mice

Researchers have developed a new 3D vaccine that spontaneously assembles to provide a more effective way to harness the immune system to fight cancer as well as infectious diseases. The vaccine spontaneously assembles into a scaffold once injected under the skin and is capable of recruiting, housing, and manipulating immune cells to generate a powerful […]

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New Insight Into HIV Vaccination Strategies

February 6, 2015

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New Research Yields Insight Into Generating Antibodies That Target Different Strains of HIV

New research yields insight into generating antibodies that target different strains of HIV, suggesting that sequentially administering several different forms of a potential HIV vaccine could stimulate a stronger immune response than delivering a cocktail of these variants all at once. Through an investigation of a fundamental process that guides the maturation of immune cells, […]

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Researchers May Have Pinpointed a Strategy for Eliminating Latent HIV

January 8, 2015

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Study Shows Broad Immune Response May be Needed to Destroy Latent HIV

A newly published study shows promise as the future direction for the development of a therapeutic vaccine to clear HIV. A major barrier to finding a cure for HIV/AIDS is the presence of latent HIV in the cells of chronically infected individuals. But a team of Yale and Johns Hopkins researchers may have pinpointed a […]

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Onset of Schizophrenia Linked to Elevated Neural Links

January 7, 2015

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Schizophrenia Onset Linked to Elevated Neural Links

New research from Yale scientists, in conjunction with colleagues at the Huaxi Magnetic Resonance Research Center at Sichuan University in China, reveals that that the onset of the schizophrenia is marked by an abnormal spike in neural connections. In its chronic stage, schizophrenia is typically marked by a dearth of links between brain cells in […]

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Scientists Shed New Light on How ‘Microbial Dark Matter’ Might Cause Disease

December 31, 2014

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How Microbial Dark Matter Might Cause Disease

A landmark discovery reveals new insights on the biological, ecological and medical importance of TM7, and could lead to better understanding of other elusive bacteria. One of the great recent discoveries in modern biology was that the human body contains 10 times more bacterial cells than human cells. But much of that bacteria is still […]

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Yale Study Shows HIV Protease Inhibitors Also Offer Protection Against Malaria

December 19, 2014

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AIDS Drug Offers Protection Against Malaria

New research from Yale University shows that the use of protease inhibitor-based antiretroviral therapy for HIV is an effective measure for reducing malaria in HIV-infected children in most regions of sub-Saharan Africa. Children with HIV/AIDS in Africa are at a higher-than-average risk for another deadly disease: malaria. But a team of Yale School of Public […]

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Yale Study Shows Ebola Virus Spreads in Social Clusters

December 16, 2014

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Researchers Reveal Ebola Virus Spreads in Social Clusters

Using both genomic and epidemiological data from the current outbreak in Sierra Leone, researchers from Yale University discovered that the Ebola virus spreads in social clusters – a finding that has ramifications for case reporting and the public health. Prior studies of Ebola transmission were based on models that assumed the spread of infection occurred […]

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New Research Details Why Typhoid Toxin Targets Only Humans

December 8, 2014

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Study Reveals Why Typhoid Toxin Targets Only Humans

Scientists at Yale and UC San Diego have discovered why typhoid toxin targets only humans, revealing a single oxygen atom is the cause. The bacterium Salmonella Typhi causes typhoid fever in humans, but leaves other mammals unaffected. Researchers at University of California, San Diego and Yale University Schools of Medicine now offer one explanation — […]

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Researchers Uncover an Easily Detectable Precancerous State in Blood

December 4, 2014

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Researchers Uncovered a Detectable Precancerous State in Blood

Two newly published studies detail the discovery of a precancerous state found in blood, paving the way for research that focuses on detection and prevention of blood cancers. Researchers from the Broad Institute of MIT and Harvard, Harvard Medical School, the Harvard Stem Cell Institute (HSCI), and Harvard-affiliated hospitals have uncovered an easily detectable, “premalignant” […]

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Proper Copper Levels Essential to Spontaneous Neural Activity

December 2, 2014

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Proper Copper Levels Essential to Spontaneous Neural Activity

A new study from the Berkeley Lab reveals that proper copper levels are essential to the health of a brain at rest and suggests that mismanagement of copper in the brain linked to Alzheimer’s and other neurological disorders can also contribute to misregulation of signaling in cell−to-cell communications. In recent years it has been established […]

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Discovery Hints at New Strategy for Fighting HIV

November 19, 2014

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New Strategy for Fighting HIV

Researchers from Yale University have discovered an immune system reaction that may open a new avenue in the fight against HIV. The discovery of the innate immunity system’s role in mobilizing the body’s defenses against invading microorganisms has been long studied at Yale. Now in the November 17 issue of the journal Nature Immunology, Yale […]

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Yale Researchers Develop Method to Attack Cancer at Its Source

November 18, 2014

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Yale Develops Method to Attack Cancer at Its Genetic Source

A team of researchers at Yale University has developed a therapeutic molecule that both targets the acidic microenvironments of tumors and penetrates cells to deliver a therapeutic cargo. MicroRNAs may be tiny — as few as 20 genetic letters, compared to 3 billion in the DNA of a human — but they play a major […]

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New Algorithm Predicts the Evolution of Viruses

November 12, 2014

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Algorithm Can Predict the Evolution of Viruses

Using the branches of a genealogical tree as reference, a team of scientists has developed an algorithm that can predict the evolution of asexual organisms such as viruses or cancer cells. For a long time, prognoses forecasting the evolutionary future of organisms were considered mere speculation. Together with researchers from Cambridge and Santa Barbara, USA, […]

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