Disease News

Biochemists Identify Another Piece of the Parkinson’s Disease Pathology Puzzle

January 28, 2016

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Researchers Identify another Piece in the Parkinson's Disease Pathology Puzzle

An international team has discovered that the LRRK2 kinase regulates cellular trafficking by deactivating Rab proteins. This finding illuminates a novel route for therapeutic development and may accelerate testing of LRRK2 inhibitors as a disease-modifying therapy for Parkinson’s, the second most common neurodegenerative disease. An international public-private research consortium has identified and validated a cellular […]

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Yale Researchers Identify Molecular Link between Obesity and Fatty Liver Disease

January 26, 2016

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New Link between Obesity and a Common Liver Disease Discovered

The high levels of obesity in the United States contribute to fatty liver disease, the most common form of liver disease. A newly published study from Yale University identifies molecular links between the two, and points to a possible therapy. Fatty liver disease — also known as nonalcoholic steatohepatitis or NASH — frequently progresses to […]

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Yale Examines How Bacteria Might Trigger and Treat Autoimmune Disease

January 11, 2016

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How Beneficial Bacteria Inside Our Bodies Might Trigger and Treat Autoimmune Disease

New research from Yale University is exploring how beneficial bacteria that live in the gut might trick the body into an autoimmune reaction known as antiphospholipid syndrome. Doctors often describe the body’s immune system in military terms. Physical barriers such as skin and mucus prevent invasion by disease-causing pathogens such as bacteria and viruses. If […]

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New Research Reveals How Cancer Cells Escape Blood Vessels

December 16, 2015

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Scientists Reveal How Cancer Cells Escape Blood Vessels

A newly published study from MIT and Massachusetts General Hospital reveals how cancer cells latch onto blood vessels and invade tissues to form new tumors — a finding that could help researchers develop drugs that inhibit this process and prevent cancers from metastasizing. Cancer cells circulating in the bloodstream can stick to blood vessel walls […]

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Scientists Develop “Kill Switches” for Engineered Bacteria

December 14, 2015

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Engineered Bacteria with Kill Switches

To prevent genetically modified bacteria from escaping into the wider environment, MIT researchers have developed safeguards in the form of two so-called “kill switches,” which they call “Deadman” and “Passcode.” These kill switches can cause synthetic bacteria to die without the presence of certain chemicals. Many research teams are developing genetically modified bacteria that could […]

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Yale Researchers Discover New Complexities Behind Drug Resistance

December 10, 2015

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New Study Probes Genes for Clues to Drug Resistance in Aggressive Breast Cancer

New research from Yale University probes genes for clues to drug resistance in aggressive breast cancer. By sifting through the 20,000 protein-encoding genes in the human genome, Yale researchers discovered new complexities behind drug resistance and identified patterns of mutations that could predict which therapies will benefit patients with aggressive breast cancer. The findings will […]

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Yale Study Shows Topical Ruxolitinib Grows Hair

December 9, 2015

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Topical Ruxolitinib Helps Teen Grow Hair

A new study from Yale University reveals that a topical formulation of an oral medication used to treat bone marrow diseases can be used to grow hair. A young woman who had no scalp or eyebrow hair for years now enjoys a full mane after using a novel cream devised by researchers at Yale School […]

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Scientists Develop a New Way to Deliver MicroRNAs for Cancer Treatment

December 8, 2015

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Researchers Develop a New Way to Deliver MicroRNAs

By twisting RNA strands into a triple helix and embedding them in a biocompatible gel, researchers from MIT have developed a new way to shrink tumors in mice with an aggressive form of breast cancer. Twenty years ago, scientists discovered that short strands of RNA known as microRNA help cells to fine-tune their gene expression. […]

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New Strategy to Better Protect Cancer Patients from the Flu

December 7, 2015

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New Vaccine Better Protects Cancer Patients from Flu

Scientists from Yale University have developed a new vaccine strategy that reduces the risk of flu infections in cancer patients at highest risk for influenza. The findings were presented December 6 at the 57th annual meeting of the American Society of Hematology in Orlando, Florida. Patients with cancers of the immune system, like multiple myeloma, […]

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Yale Study Shows Protein IL-18 Contributes to Colitis

December 4, 2015

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Researchers Identify Key Protein That Contributes to Colitis

New research from Yale University identifies that the protein IL-18 plays a key part in the development of the colitis. The cause of Ulcerative Colitis, a debilitating disease of the intestine, is unclear. A Yale-led study has illuminated the role of a protein that plays a key part in the development of the condition. The […]

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Study Shows Amateur Contact Sports Increase Risk of Degenerative Disorder

December 2, 2015

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Football Increases Risk of Degenerative Disorder

Past evidence has shown that professional football players are susceptible to a progressive degenerative disease, chronic traumatic encephalopathy (CTE), which is caused by repetitive brain trauma. Now a new study from the Mayo Clinic reveals a significant and surprising amount of CTE in males who had participated in amateur contact sports in their youth. About […]

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Yale Study Shows Enhanced Treatment for Hepatitis C Could Cut Prevalence by 80%

December 1, 2015

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New Treatment for Hepatitis C Could Cut Prevalence by 80%

New research from Yale University shows that novel antiviral therapies for hepatitis C could reduce the prevalence of the blood-borne infection by more than 80%. The finding raises the possibility of greatly reducing, and even eliminating, hepatitis C in the United States if enhanced screening and treatment efforts target high-risk populations. The study published online […]

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How Genetic Defects in Myelin Formation Cause White Matter Diseases

November 17, 2015

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Yale Researchers Show How a Mutated Gene Wreaks Havoc on White Matter

New research from Yale University may shed insight into mechanisms to control the course of multiple sclerosis. Their results point to a role for FAM126A in supporting myelination, an important process in development and also following acute exacerbations in multiple sclerosis. An inherited disease of myelin marked by slow, progressive neurological impairment is caused by […]

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Experimental Alzheimer’s Drug J147 Shows Anti-Aging Effects

November 13, 2015

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Experimental Alzheimer's Drug Shows Anti-Aging Effects

New research from the Salk Institute shows that the experimental Alzheimer’s drug J147 has a host of unexpected anti-aging effects in animals. The Salk team expanded upon their previous development of a drug candidate, called J147, which takes a different tack by targeting Alzheimer’s major risk factor–old age. In the new work, the team showed […]

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New Model Maps the Development of Stem Cells in the Human Body

November 13, 2015

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New Model Analyses of the Development of Stem Cells

Using the telomeres on the chromosomes of blood cells, scientists have designed a mathematical model for mapping the development of populations of haematopoietic stem cells with advancing age. Stem cells ensure the regeneration and maintenance of the body’s tissues. Diseases like cancer can arise if they spiral out of control. In collaboration with doctors from […]

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Genetically Reducing AMPK Activity May Prevent Hereditary Hearing Loss

November 9, 2015

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New Genetic Modification May Prevent Hearing Loss

New research from Yale University reveals that genetically reducing AMPK activity delays hereditary hearing loss in mice. Hereditary hearing loss can worsen over time and lead to premature deafness. In a new study, a Yale-led research team successfully applied genetic modification to delay inherited hearing loss in mice. Led by professor of pathology and genetics […]

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New Chemical Compound Could Clear Up Cataracts

November 6, 2015

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New Chemical Eye Drops Could Clear Up Cataracts

A team of scientists has identified a chemical that could potentially be used in eye drops to reverse cataracts. Identified as a “priority eye disease” by the World Health Organization, cataracts — caused when the lenses of the eyes lose their transparency — affect more than 20 million people worldwide. Although cataracts can be successfully […]

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New Synthetic Process Provides a Better View of Diabetes, Inflammation, and Human Aging

October 19, 2015

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New Process Provides a Better View of Diabetes, Inflammation, and Human Aging

In a newly published study, scientists describe the new synthesis, as well as a new synthetic methodology, that offers a better glimpse into diabetes and the aging process. A synthetic process developed at Yale University will allow researchers to study a key molecule involved in diabetes, inflammation, and human aging. The new process synthesizes glucosepane, […]

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