Disease News

New Yale Studies Explore the Science of Cardiovascular Diseases

September 26, 2016

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Cardiologists Explore the Science of Cardiovascular Diseases

Yale University scientists detail how basic science research insights are key to future breakthroughs in cardiovascular disease. Professor of cardiology Martin A. Schwartz led two recently published studies that advance knowledge of the underlying biology of cardiovascular diseases, which are among the most common causes of chronic illness and death worldwide. The first study, published […]

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Genomic Regions That Set Humans Apart From Other Primates Carry Many Autism-Linked Mutations

September 22, 2016

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Autism and Evolution

New research from Harvard Medical School suggests that mutations in genetic regulatory elements may be important in both autism spectrum disorder and human evolution. Small regions of the genome where humans have diverged from chimpanzees contain a variety of mutations implicated in autism and other neurodevelopmental disorders, report Harvard Medical School researchers at Boston Children’s […]

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New MIT Gene Therapy Technique May Help Prevent Cancer Metastasis

September 21, 2016

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New Gene Therapy Technique May Help Prevent Cancer Metastasis

MIT researchers have developed a new gene therapy technique that uses microRNAs — small noncoding RNA molecules that regulate gene expression — to control breast cancer metastasis. The spread of malignant cells around the body, known as metastasis, is the leading cause of mortality in women with breast cancer. Now, a new gene therapy technique […]

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MIT Scientists Develop New Method to Deliver Beneficial Bacteria to the GI Tract

September 20, 2016

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Researchers Develop New Method to Deliver Beneficial Bacteria to the GI Tract

By coating bacteria with polymer layers that protect them from the acids and bile salts found in the digestive tract, scientists from MIT have developed a new strategy for delivering large numbers of beneficial bacterial to the human gut. The human digestive tract contains trillions of bacteria, many of which help digest food and fight […]

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New T Cell Subsets Have Potential to Improve Cellular Therapy for Cancer

September 14, 2016

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Researchers Identify New T cell Subsets with Potential to Improve Cellular Therapy for Cancer

Researchers from the Yale Cancer Center have identified that two genes, NR4A1 and ABC transporters, mark a distinct subset of quiescent T cells within human tissues, and have developed methods to mobilize them into circulation for potential application in adoptive T cell therapy of cancer. The study is published in the Journal of Clinical Investigation. […]

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Study Reveals a Promising New Target to Treat Type 2 Diabetes

August 31, 2016

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Yale Study Reveals Protein to Target in Type 2 Diabetes

Scientists at Yale University reveal promising new target for drugs to treat type 2 diabetes. When the body’s cells don’t respond normally to insulin — a condition known as insulin resistance — blood glucose levels can increase, resulting in type 2 diabetes. Researchers have long known that insulin resistance is linked to defects in the […]

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Harvard Researchers Identify a Key Instigator in Lou Gehrig’s Disease

August 26, 2016

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Scientists Identify Instigator That Ignites Nerve Cell Damage in Lou Gehrig’s Disease

A team of scientists from Harvard Medical School has identified a key instigator of nerve cell damage in people with amyotrophic lateral sclerosis, a progressive and incurable neurodegenerative disorder. Researchers say the findings of their study, published in the journal Science, may lead to new therapies to halt the progression of the uniformly fatal disease […]

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New Reserach Reveals How Zika Virus Causes Fetal Brain Damage

August 24, 2016

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Yale Reserachers Discover How Zika Virus Causes Fetal Brain Damage

In a newly published study, researchers from Yale University report that infection by the Zika virus diverts a key protein necessary for neural cell division in the developing human fetus, thereby causing the birth defect microcephaly. The findings suggest that Zika virus might be susceptible to existing antiviral drugs that may prevent disruption to the […]

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Yale Scientists Discover a New Therapy for a Chronic Brain Disease

August 23, 2016

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Yale Biologists Uncover Marker for a Chronic Brain Disease

Yale scientists have discovered a new and effective therapy for cerebral cavernous malformations. A team of researchers led by Yale professor of pathology Wang Min have pinpointed a marker that contributes to a chronic condition affecting the brain. Known as cerebral cavernous malformations, the condition is characterized by a tangle of capillaries in the brain’s […]

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MIT Biological Engineers Program Human Cells to Store Complex Histories in Their DNA

August 22, 2016

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Recording Analog Memories in Human Cells

Newly published research details how biological engineers from MIT developed a way to record complex histories in the DNA of human cells, allowing them to retrieve “memories” of past events by sequencing the DNA. This analog memory storage system — the first that can record the duration and/or intensity of events in human cells — […]

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New Yale Research Reveals Insights into Alcoholic Liver Disease

August 11, 2016

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New Insights into Alcoholic Liver Disease

A team of researchers at the Yale School of Public Health has identified a novel mechanism that protects the liver against the accumulation of fats and may represent a promising new therapeutic approach for treating and/or preventing alcoholic liver disease (ALD) and other fatty liver diseases. Professor Vasilis Vasiliou, chair of the Department of Environmental […]

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Adhesive Patch Delivers Therapy to Tumor Sites

August 1, 2016

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New Device Delivers Therapy to Tumor Sites

A newly published study from MIT describes an adhesive patch that can stick to the tumor site, either before or after surgery, to deliver a triple-combination of drug, gene, and photo (light-based) therapy. Approximately one in 20 people will develop colorectal cancer in their lifetime, making it the third-most prevalent form of the disease in […]

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Yale Scientists Recode Organisms to Resist Viral Contamination

July 18, 2016

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Scientists Recode Organisms to Resist Viral Contamination

Scientists from Yale University have discovered a novel way to combat viral contamination of bio-factories that produce a growing number of drugs, chemicals, and fuels. The new method involves recoding organisms to stop horizontal transfer of genes — which viruses use to infect and hijack cellular machinery to reproduce. The study is published in the […]

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New Study Improves Our Understanding of Intercellular Communication

July 6, 2016

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Biologists Improve Our Understanding of Intercellular Communication

New research reveals how cells can pack and release active ephrins and Eph receptors through extracellular vesicles, improving our understanding of intercellular communication and paving the way for new therapeutic strategies. Eph receptors and their partner proteins, the ephrins, are vital for intercellular communication. In the developing brain, they guide young neurons to the right […]

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Engineers Design Programmable RNA Vaccines That Protext Against Ebola and H1N1 Influenza

July 5, 2016

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MIT Engineers Design Programmable RNA Vaccines

A newly published study details how engineers developed programmable RNA vaccines that work against Ebola, H1N1 influenza, and a common parasites in mice. MIT engineers have developed a new type of easily customizable vaccine that can be manufactured in one week, allowing it to be rapidly deployed in response to disease outbreaks. So far, they […]

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Yale Study Shows Surprising Link Between Constipation and Herpes Infection

June 9, 2016

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Surprising Link Between Constipation and Herpes Infection

New research from Yale University shows a surprising link between constipation and herpes infection. The new research, published June 8 in Cell Host & Microbe, advances the science on herpes, and could help patients with chronic gastrointestinal diseases with no clear cause. Individuals with herpes have reported seemingly unrelated symptoms such as constipation and urinary […]

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New Combination Therapy Cures Tick-Borne Illness in Mice

June 6, 2016

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New Therapy Cures Tick-Borne Illness in Mice

Yale researchers have developed a new therapy that cures the emerging infectious disease, babesiosis, which is transmitted by the same ticks that transmit the agents of Lyme disease. This “radical” therapy not only clears the infection but also prevents the recurrence that often occurs with existing treatments. The study was published online June 6 in […]

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Study Shows MRI Detects Early Signs of Schizophrenia

June 3, 2016

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MRI Detects Early Signs of Schizophrenia

A new study from Yale University shows that an MRI can detect early signs of schizophrenia in a rodent model. Patients with schizophrenia often exhibit early signs of behavioral abnormalities. However, changes in the brain underlying these behavioral signs have not been identified. Applying magnetic resonance scanning techniques that are used in humans, Yale researchers […]

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