Disease News

New Technique Uses Regenerative Capacity of Stem Cells to Eliminate HIV

July 6, 2015

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Stem Cell Gene Therapy Holds Promise for Eliminating HIV

Scientists at UCLA have developed a new technique that harnesses the regenerative capacity of stem cells to generate an immune response to HIV, showing that the technique decreased HIV levels in mice by 80 to 95 percent. Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research are one […]

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Nanoparticles Shut Down Cancer Growth

July 3, 2015

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Nanoparticles Shut Down Cancer Growth

Using nanoparticles to deliver a nucleic acid (siRNA) into tumor cells in mouse models, scientists from UCLA and City of Hope have become the first to inhibit the mechanism that drives cancer growth. When scientists develop cancer therapies, they target the features that make the disease deadly: tumor growth, metastasis, recurrence and drug resistance. In […]

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Yale Study Reveals Why BRCA Gene Resists Cancer Treatment

July 3, 2015

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New Discovery Reveals Why BRCA Gene Resists Cancer Treatment

A newly published study from Yale University reveals how biochemists might be able to decrease drug resistance to existing therapies that target ovarian and breast cancer. Yale University researchers have discovered why a key molecular assistant is crucial to the function of the BRCA2 gene, which in some mutant forms can lead to ovarian and […]

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New Test Diagnoses Ebola in Minutes

July 2, 2015

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A New Test Diagnose Ebola in Minutes

Harvard Medical School researchers and their partners have shown that a new test can accurately diagnose the Ebola virus disease within minutes at the point of care, providing clinicians with on-the-spot information for treating patients and containing outbreaks. Researchers from Harvard Medical School (HMS), Partners In Health, and Boston Children’s Hospital have shown that a […]

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Crystals Grown in Microgravity Lead to New Therapeutics for Disease

July 1, 2015

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Crystals Grown in Microgravity Lead to New Therapeutics for Disease

The newest Benefits for Humanity video highlights how high-quality crystals grown in microgravity lead to new therapeutics for disease. In one of many direct Earth applications of International Space Station research, the newest Benefits for Humanity video in the Benefits series highlights how the investigation of protein crystals in space is helping to treat Duchenne […]

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Lysosomes May Contribute to Alzheimer’s Disease

June 30, 2015

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Lysosomes May Contribute to Alzheimer's

New research from Yale University shows lysosomes, the “garbage disposal” systems of cells, can fail and perhaps contribute to Alzheimer’s disease. Lysosomes, the “garbage disposal” systems of cells, are found in great abundance near the amyloid plaques in the brain that are a hallmark of Alzheimer’s disease. Scientists have long assumed that their presence was […]

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Cell-Squeezing Device Opens New Possibilities for Cell-Based Vaccines

May 22, 2015

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Cell Squeezing Device Opens New possibilities for Cell-Based Vaccines

A newly published study details how researchers from MIT developed a new microfluidic cell-squeezing device, opening new possibilities for cell-based vaccines. MIT researchers have shown that they can use a microfluidic cell-squeezing device to introduce specific antigens inside the immune system’s B cells, providing a new approach to developing and implementing antigen-presenting cell vaccines. Such […]

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A Promising New Treatment for Multiple Sclerosis

May 15, 2015

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Researchers Solve Multiple Sclerosis Puzzle

New research shows that auto-reactive T cells in MS patients produce different types of inflammatory hormones called cytokines than they do in healthy subjects, opening the door to new treatments for the disease. Evidence has long suggested multiple sclerosis (MS) is an autoimmune disease, but researchers have been puzzled because they found the same T […]

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A New Study Links Infant Antibiotic Use to Adult Diseases

May 14, 2015

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Infant Antibiotic Use Linked to Adult Diseases

New research from the University of Minnesota reveals a three-way link among antibiotic use in infants, changes in the gut bacteria, and disease later in life. Imbalances in gut microbes have been tied to infectious diseases, allergies and other autoimmune disorders, and even obesity. The study, led by Biomedical Informatics and Computational Biology program graduate […]

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Brown Researchers Reveal Inhibitor for COPD Lung Destruction

May 6, 2015

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Researchers Find Inhibitor for COPD Lung Destruction

A newly published study reveals that cigarette smoke reduces expression of the protein NLRX1 in the lung, taking the restraints off a destructive immune response that results in COPD. Providence, Rhode Island (Brown University) — In a new study, a research team based at Brown and Yale implicates a specific mitochondrial protein and pathway in […]

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Fewer Doses of Prophylaxis Provides Near-Optimal Protection Against RSV

April 23, 2015

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Fewer Doses of Prophylaxis Provides Near-Optimal Protection

Researchers from Yale and the National Institutes of Health and the Agency for Healthcare Research and Quality reveal that fewer doses of the antibody for Respiratory Syncytial Virus can be given to children and still offer near-optimal protection. Respiratory Syncytial Virus, or RSV, is the most common cause of bronchiolitis and pneumonia in U.S. children […]

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New HIV Finding Dampens Hopes of an Impending Cure

March 27, 2015

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New Finding Dampens Hopes of an HIV Cure

New research from Yale University shows that HIV can establish itself in the brain as soon as four months after initial infection, dampening the hopes of an impending cure for a disease that afflicts more than 35 million people. Within two years of infection, a genetically distinct version of HIV replicates in the brains of […]

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Study Shows Bacterial Infection, C. dificile, Widespread in the United States

March 9, 2015

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Bacterial Infection Widespread in the United States

Using population-based surveillance data, new research estimates that the germ Clostridium difficile caused nearly half a million infections in the United States in a single year. A new federal study estimates that the germ Clostridium difficile, more commonly known as C. difficile, caused nearly half a million infections in the United States in a single […]

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Possible Signs of Progress in the Fight Against Parkinson’s

March 4, 2015

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Signs of Progress Against Parkinson’s

By using induced pluripotent stem cells, researchers have markedly reduced the symptoms Parkinson’s disease in primates. Harvard Stem Cell Institute (HSCI) researchers at University-affiliated McLean Hospital have taken what they describe as an important step toward using the implantation of stem cell-generated neurons as a treatment for Parkinson’s disease. Ole Isacson and colleagues reported that […]

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Scientists Reverse Type 2 Diabetes and Fatty Liver Disease

March 2, 2015

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Researchers Reverse type 2 Diabetes and Fatty Liver Disease

A newly published study reveals how scientists from Yale University developed a controlled-release oral therapy that reversed type 2 diabetes and fatty liver disease in rats. Existing therapies for type 2 diabetes, and the closely associated conditions of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), have had limited success at treating the root […]

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New Anti-HIV Candidate Blocks Every Strain of HIV-1, HIV-2 and SIV

February 18, 2015

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Scientists Announce New Anti-HIV Agent

In a new study, researchers show that a new drug candidate blocks every strain of HIV-1, HIV-2 and SIV that has been isolated from humans or rhesus macaques, including the hardest-to-stop variants. Jupiter, Florida – February 18, 2015 – In a remarkable new advance against the virus that causes AIDS, scientists from the Jupiter, Florida […]

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3D Vaccine Spontaneously Assembles to Fight Cancer, Infectious Diseases

February 9, 2015

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3D Vaccine Delays Tumor Growth in Mice

Researchers have developed a new 3D vaccine that spontaneously assembles to provide a more effective way to harness the immune system to fight cancer as well as infectious diseases. The vaccine spontaneously assembles into a scaffold once injected under the skin and is capable of recruiting, housing, and manipulating immune cells to generate a powerful […]

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New Insight Into HIV Vaccination Strategies

February 6, 2015

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New Research Yields Insight Into Generating Antibodies That Target Different Strains of HIV

New research yields insight into generating antibodies that target different strains of HIV, suggesting that sequentially administering several different forms of a potential HIV vaccine could stimulate a stronger immune response than delivering a cocktail of these variants all at once. Through an investigation of a fundamental process that guides the maturation of immune cells, […]

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