Disease News

Yale Study Shows One in Four Hepatitis C Patients Denied Initial Drug Therapy

August 28, 2015

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Yale Study Shows One in Four Hepatitis C Patients Denied Initial Care

A new study from the Yale School of Medicine found that nearly one in four patients with chronic hepatitis C (HCV) are denied initial approval for a drug therapy that treats the most common strain of the infection. The finding, published August 27 in PLOS ONE, identifies a new barrier to caring for patients with […]

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Biologists Identify a New Approach to Cancer Immunotherapy

August 27, 2015

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A New Approach to Cancer Immunotherapy

Scientists from Yale University have identified a new way to boost immune response by metabolically “rewiring” immune cells. Inside a tumor, immune cells and cancer cells battle for survival. The advantage may go to the cells that metabolize the most glucose, say Yale researchers who have identified a new way to boost immune response by […]

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Scientists Develop New Technique To Improve Kidney Research

August 25, 2015

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Scientists Develop New Technique for Kidney Research

Scientists at Yale School of Medicine have developed a new 3D-imaging technique to better understand and to help treat kidney disease. One in four patients treated with the widely used anti-cancer drug cisplatin develop chronic kidney disease. To better understand how the treatment leads to kidney damage, and possibly prevent it, a team of researchers […]

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Calprotectin Plays a Key Role in Blocking Pathogen Survival

August 24, 2015

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Calprotectin Fends off Microbial Invaders

New research from MIT reveals the process by which human calprotectin prevents invading pathogens from obtaining iron. Invading microbial pathogens must scavenge essential nutrients from their host organism in order to survive and replicate. To defend themselves from infection, hosts attempt to block pathogens’ access to these nutrients. Now researchers at MIT have discovered the […]

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Yale Study Links Depression During Pregnancy to Risky Postpartum Sexual Behavior

August 21, 2015

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Study Links Depression During Pregnancy to Risky Postpartum Sexual Behavior

New research from Yale reveals that among young, urban women of color, depressive symptoms can start during pregnancy and can be a precursor to risky sexual behavior after a baby is born. The researchers, led by Shayna Cunningham, Ph.D., research scientist in Chronic Disease Epidemiology, did a randomized controlled trial of 1,233 females between the […]

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Unexpected Discovery Offers Insight into Mechanisms of Asthma, Other Diseases

August 17, 2015

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New Research Offers Insight into Mechanisms of Asthma and Other Diseases

A new study from the Harvard T.H. Chan School of Public Health reveals an unexpected discovery – In people with asthma, the cells that line the airways in the lungs are unusually shaped and “scramble around like there’s a fire drill going on.” The findings could also have important ramifications for research in other areas, […]

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New Technique Uses Regenerative Capacity of Stem Cells to Eliminate HIV

July 6, 2015

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Stem Cell Gene Therapy Holds Promise for Eliminating HIV

Scientists at UCLA have developed a new technique that harnesses the regenerative capacity of stem cells to generate an immune response to HIV, showing that the technique decreased HIV levels in mice by 80 to 95 percent. Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research are one […]

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Nanoparticles Shut Down Cancer Growth

July 3, 2015

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Nanoparticles Shut Down Cancer Growth

Using nanoparticles to deliver a nucleic acid (siRNA) into tumor cells in mouse models, scientists from UCLA and City of Hope have become the first to inhibit the mechanism that drives cancer growth. When scientists develop cancer therapies, they target the features that make the disease deadly: tumor growth, metastasis, recurrence and drug resistance. In […]

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Yale Study Reveals Why BRCA Gene Resists Cancer Treatment

July 3, 2015

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New Discovery Reveals Why BRCA Gene Resists Cancer Treatment

A newly published study from Yale University reveals how biochemists might be able to decrease drug resistance to existing therapies that target ovarian and breast cancer. Yale University researchers have discovered why a key molecular assistant is crucial to the function of the BRCA2 gene, which in some mutant forms can lead to ovarian and […]

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New Test Diagnoses Ebola in Minutes

July 2, 2015

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A New Test Diagnose Ebola in Minutes

Harvard Medical School researchers and their partners have shown that a new test can accurately diagnose the Ebola virus disease within minutes at the point of care, providing clinicians with on-the-spot information for treating patients and containing outbreaks. Researchers from Harvard Medical School (HMS), Partners In Health, and Boston Children’s Hospital have shown that a […]

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Crystals Grown in Microgravity Lead to New Therapeutics for Disease

July 1, 2015

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Crystals Grown in Microgravity Lead to New Therapeutics for Disease

The newest Benefits for Humanity video highlights how high-quality crystals grown in microgravity lead to new therapeutics for disease. In one of many direct Earth applications of International Space Station research, the newest Benefits for Humanity video in the Benefits series highlights how the investigation of protein crystals in space is helping to treat Duchenne […]

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Lysosomes May Contribute to Alzheimer’s Disease

June 30, 2015

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Lysosomes May Contribute to Alzheimer's

New research from Yale University shows lysosomes, the “garbage disposal” systems of cells, can fail and perhaps contribute to Alzheimer’s disease. Lysosomes, the “garbage disposal” systems of cells, are found in great abundance near the amyloid plaques in the brain that are a hallmark of Alzheimer’s disease. Scientists have long assumed that their presence was […]

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Cell-Squeezing Device Opens New Possibilities for Cell-Based Vaccines

May 22, 2015

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Cell Squeezing Device Opens New possibilities for Cell-Based Vaccines

A newly published study details how researchers from MIT developed a new microfluidic cell-squeezing device, opening new possibilities for cell-based vaccines. MIT researchers have shown that they can use a microfluidic cell-squeezing device to introduce specific antigens inside the immune system’s B cells, providing a new approach to developing and implementing antigen-presenting cell vaccines. Such […]

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A Promising New Treatment for Multiple Sclerosis

May 15, 2015

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Researchers Solve Multiple Sclerosis Puzzle

New research shows that auto-reactive T cells in MS patients produce different types of inflammatory hormones called cytokines than they do in healthy subjects, opening the door to new treatments for the disease. Evidence has long suggested multiple sclerosis (MS) is an autoimmune disease, but researchers have been puzzled because they found the same T […]

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A New Study Links Infant Antibiotic Use to Adult Diseases

May 14, 2015

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Infant Antibiotic Use Linked to Adult Diseases

New research from the University of Minnesota reveals a three-way link among antibiotic use in infants, changes in the gut bacteria, and disease later in life. Imbalances in gut microbes have been tied to infectious diseases, allergies and other autoimmune disorders, and even obesity. The study, led by Biomedical Informatics and Computational Biology program graduate […]

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Brown Researchers Reveal Inhibitor for COPD Lung Destruction

May 6, 2015

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Researchers Find Inhibitor for COPD Lung Destruction

A newly published study reveals that cigarette smoke reduces expression of the protein NLRX1 in the lung, taking the restraints off a destructive immune response that results in COPD. Providence, Rhode Island (Brown University) — In a new study, a research team based at Brown and Yale implicates a specific mitochondrial protein and pathway in […]

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Fewer Doses of Prophylaxis Provides Near-Optimal Protection Against RSV

April 23, 2015

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Fewer Doses of Prophylaxis Provides Near-Optimal Protection

Researchers from Yale and the National Institutes of Health and the Agency for Healthcare Research and Quality reveal that fewer doses of the antibody for Respiratory Syncytial Virus can be given to children and still offer near-optimal protection. Respiratory Syncytial Virus, or RSV, is the most common cause of bronchiolitis and pneumonia in U.S. children […]

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New HIV Finding Dampens Hopes of an Impending Cure

March 27, 2015

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New Finding Dampens Hopes of an HIV Cure

New research from Yale University shows that HIV can establish itself in the brain as soon as four months after initial infection, dampening the hopes of an impending cure for a disease that afflicts more than 35 million people. Within two years of infection, a genetically distinct version of HIV replicates in the brains of […]

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