Disease News

Cell-Squeezing Device Opens New Possibilities for Cell-Based Vaccines

May 22, 2015

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Cell Squeezing Device Opens New possibilities for Cell-Based Vaccines

A newly published study details how researchers from MIT developed a new microfluidic cell-squeezing device, opening new possibilities for cell-based vaccines. MIT researchers have shown that they can use a microfluidic cell-squeezing device to introduce specific antigens inside the immune system’s B cells, providing a new approach to developing and implementing antigen-presenting cell vaccines. Such […]

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A Promising New Treatment for Multiple Sclerosis

May 15, 2015

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Researchers Solve Multiple Sclerosis Puzzle

New research shows that auto-reactive T cells in MS patients produce different types of inflammatory hormones called cytokines than they do in healthy subjects, opening the door to new treatments for the disease. Evidence has long suggested multiple sclerosis (MS) is an autoimmune disease, but researchers have been puzzled because they found the same T […]

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A New Study Links Infant Antibiotic Use to Adult Diseases

May 14, 2015

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Infant Antibiotic Use Linked to Adult Diseases

New research from the University of Minnesota reveals a three-way link among antibiotic use in infants, changes in the gut bacteria, and disease later in life. Imbalances in gut microbes have been tied to infectious diseases, allergies and other autoimmune disorders, and even obesity. The study, led by Biomedical Informatics and Computational Biology program graduate […]

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Brown Researchers Reveal Inhibitor for COPD Lung Destruction

May 6, 2015

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Researchers Find Inhibitor for COPD Lung Destruction

A newly published study reveals that cigarette smoke reduces expression of the protein NLRX1 in the lung, taking the restraints off a destructive immune response that results in COPD. Providence, Rhode Island (Brown University) — In a new study, a research team based at Brown and Yale implicates a specific mitochondrial protein and pathway in […]

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Fewer Doses of Prophylaxis Provides Near-Optimal Protection Against RSV

April 23, 2015

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Fewer Doses of Prophylaxis Provides Near-Optimal Protection

Researchers from Yale and the National Institutes of Health and the Agency for Healthcare Research and Quality reveal that fewer doses of the antibody for Respiratory Syncytial Virus can be given to children and still offer near-optimal protection. Respiratory Syncytial Virus, or RSV, is the most common cause of bronchiolitis and pneumonia in U.S. children […]

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New HIV Finding Dampens Hopes of an Impending Cure

March 27, 2015

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New Finding Dampens Hopes of an HIV Cure

New research from Yale University shows that HIV can establish itself in the brain as soon as four months after initial infection, dampening the hopes of an impending cure for a disease that afflicts more than 35 million people. Within two years of infection, a genetically distinct version of HIV replicates in the brains of […]

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Study Shows Bacterial Infection, C. dificile, Widespread in the United States

March 9, 2015

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Bacterial Infection Widespread in the United States

Using population-based surveillance data, new research estimates that the germ Clostridium difficile caused nearly half a million infections in the United States in a single year. A new federal study estimates that the germ Clostridium difficile, more commonly known as C. difficile, caused nearly half a million infections in the United States in a single […]

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Possible Signs of Progress in the Fight Against Parkinson’s

March 4, 2015

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Signs of Progress Against Parkinson’s

By using induced pluripotent stem cells, researchers have markedly reduced the symptoms Parkinson’s disease in primates. Harvard Stem Cell Institute (HSCI) researchers at University-affiliated McLean Hospital have taken what they describe as an important step toward using the implantation of stem cell-generated neurons as a treatment for Parkinson’s disease. Ole Isacson and colleagues reported that […]

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Scientists Reverse Type 2 Diabetes and Fatty Liver Disease

March 2, 2015

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Researchers Reverse type 2 Diabetes and Fatty Liver Disease

A newly published study reveals how scientists from Yale University developed a controlled-release oral therapy that reversed type 2 diabetes and fatty liver disease in rats. Existing therapies for type 2 diabetes, and the closely associated conditions of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH), have had limited success at treating the root […]

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New Anti-HIV Candidate Blocks Every Strain of HIV-1, HIV-2 and SIV

February 18, 2015

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Scientists Announce New Anti-HIV Agent

In a new study, researchers show that a new drug candidate blocks every strain of HIV-1, HIV-2 and SIV that has been isolated from humans or rhesus macaques, including the hardest-to-stop variants. Jupiter, Florida – February 18, 2015 – In a remarkable new advance against the virus that causes AIDS, scientists from the Jupiter, Florida […]

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3D Vaccine Spontaneously Assembles to Fight Cancer, Infectious Diseases

February 9, 2015

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3D Vaccine Delays Tumor Growth in Mice

Researchers have developed a new 3D vaccine that spontaneously assembles to provide a more effective way to harness the immune system to fight cancer as well as infectious diseases. The vaccine spontaneously assembles into a scaffold once injected under the skin and is capable of recruiting, housing, and manipulating immune cells to generate a powerful […]

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New Insight Into HIV Vaccination Strategies

February 6, 2015

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New Research Yields Insight Into Generating Antibodies That Target Different Strains of HIV

New research yields insight into generating antibodies that target different strains of HIV, suggesting that sequentially administering several different forms of a potential HIV vaccine could stimulate a stronger immune response than delivering a cocktail of these variants all at once. Through an investigation of a fundamental process that guides the maturation of immune cells, […]

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Researchers May Have Pinpointed a Strategy for Eliminating Latent HIV

January 8, 2015

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Study Shows Broad Immune Response May be Needed to Destroy Latent HIV

A newly published study shows promise as the future direction for the development of a therapeutic vaccine to clear HIV. A major barrier to finding a cure for HIV/AIDS is the presence of latent HIV in the cells of chronically infected individuals. But a team of Yale and Johns Hopkins researchers may have pinpointed a […]

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Onset of Schizophrenia Linked to Elevated Neural Links

January 7, 2015

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Schizophrenia Onset Linked to Elevated Neural Links

New research from Yale scientists, in conjunction with colleagues at the Huaxi Magnetic Resonance Research Center at Sichuan University in China, reveals that that the onset of the schizophrenia is marked by an abnormal spike in neural connections. In its chronic stage, schizophrenia is typically marked by a dearth of links between brain cells in […]

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Scientists Shed New Light on How ‘Microbial Dark Matter’ Might Cause Disease

December 31, 2014

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How Microbial Dark Matter Might Cause Disease

A landmark discovery reveals new insights on the biological, ecological and medical importance of TM7, and could lead to better understanding of other elusive bacteria. One of the great recent discoveries in modern biology was that the human body contains 10 times more bacterial cells than human cells. But much of that bacteria is still […]

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Yale Study Shows HIV Protease Inhibitors Also Offer Protection Against Malaria

December 19, 2014

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AIDS Drug Offers Protection Against Malaria

New research from Yale University shows that the use of protease inhibitor-based antiretroviral therapy for HIV is an effective measure for reducing malaria in HIV-infected children in most regions of sub-Saharan Africa. Children with HIV/AIDS in Africa are at a higher-than-average risk for another deadly disease: malaria. But a team of Yale School of Public […]

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Yale Study Shows Ebola Virus Spreads in Social Clusters

December 16, 2014

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Researchers Reveal Ebola Virus Spreads in Social Clusters

Using both genomic and epidemiological data from the current outbreak in Sierra Leone, researchers from Yale University discovered that the Ebola virus spreads in social clusters – a finding that has ramifications for case reporting and the public health. Prior studies of Ebola transmission were based on models that assumed the spread of infection occurred […]

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