Medicine News

New Mathematical Model Helps Predicts Optimal Use of Antibiotics

May 15, 2015

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Mathematical Model Predicts Optimal Use of Antibiotics

Researchers at the Yale School of Public Health have developed a new mathematical model to help predict the optimal dosing of antibiotics. Although antibiotics were first introduced more than 70 years ago, substantial uncertainty remains about how the drugs should be used by patients to ensure recovery, while minimizing toxic side effects and the risk […]

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Yale Research Shows How Renalase Protects Kidney and Heart from Injury

May 11, 2015

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Study Details How Key Protein Protects Kidney and Heart from Injury

A newly published study from Yale University details how the protein renalase protects cells from the type of severe injury that could result in a heart attack or kidney failure. The finding may lead to new treatments that protect against those conditions. Dr. Gary V. Desir, professor of medicine, and fellow researchers at Yale School […]

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TH17 Cells Convert from Pro-Inflammatory to Anti-Inflammatory

April 30, 2015

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Possible Therapeutic Strategy for Inflammation-Mediated Diseases

New research shows that TH17 cells can convert from pro-inflammatory to anti-inflammatory, revealing a possible therapeutic strategy for inflammation-mediated diseases. A type of immune cell that promotes inflammation during the immune response, TH17, can convert into another type of cell that reduces inflammation, Yale researchers have found. The finding, published April 29 in Nature, points […]

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FDA Approved Tapeworm Drug Shows Promise Against MRSA

April 24, 2015

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Tapeworm Medication Shows Promise Against MRSA

New research from Brown University and Rhode Island Hospital reveal that a common tapeworm drug (which is already approved for use in humans) effectively treated MRSA superbugs in lab cultures and in infected nematode worms. Providence, Rhode Island (Brown University) — A new study provides evidence from lab experiments that a drug already used in […]

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Implantable Device Allows Doctors to Identify the Best Chemotherapy Agents

April 24, 2015

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Implantable Device Tests Cancer Drugs in Patients

A team of engineers has developed a new implantable device that will allow doctors to test the effectiveness of cancer drugs and to identify drugs that work best for each patient prior to starting systemic administration of chemotherapy. More than 100 drugs have been approved to treat cancer, but predicting which ones will help a […]

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New Study Helps Explain Increased Risk of Diabetes in Shift Workers

April 16, 2015

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New Research Helps Explain Increased Risk of Diabetes in Shift Workers

New research from Brigham and Women’s Hospital links blood sugar and the internal clock, and may help develop and improve strategies for controlling glucose levels in day-active people and night workers. A new study may help explain why glucose tolerance — the ability to regulate blood-sugar levels — is lower at dinner than at breakfast […]

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Reg3beta Regulates Healing Process after Myocardial Infarction

March 25, 2015

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Reg3beta Controls Healing Process in the Heart

A new study from the Max Planck Institute details how Reg3beta controls the wound-healing process in the myocardium by attracting immune cells to the infarct tissue. In the wake of a myocardial infarction, parts of the myocardium die and are replaced by scar tissue. The formation and stability of scar tissue is key to the […]

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Deceased Donor Kidneys with Acute Injury Can Be Used for Transplants

March 13, 2015

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Study Reveals Injured Kidneys Can be Used for Transplants

New research from Yale University shows that kidneys from deceased donors that have acute injuries can be successfully used for transplants, instead of being discarded. The study finds that such kidneys may be more viable than previously thought, and should be considered to meet the growing demand for organ transplants. The study was published March […]

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Yale Develops a Faster and Less Expensive Way to Analyze Gene Activity

March 4, 2015

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A Faster and Less Expensive Way to Analyze Gene Activity

A newly published study details a method called modular, early-tagged amplification (META) RNA profiling that can quantify a broad panel of microRNAs or mRNAs simultaneously across many samples and requires far less sequence depth than existing digital profiling technologies. A team of Yale researchers has developed a simple method that could significantly reduce the time […]

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Antifreeze Protein Fights Frostbite in Mice

February 26, 2015

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Antifreeze Protein Fights Frostbite

A new study from Yale University shows that a protein that protects ticks from freezing temperatures also prevents frostbite when introduced in mice. This is the first study to demonstrate the protein’s ability to boost frostbite resistance in an adult mammal. The research was published February 25 in the journal PLOS ONE. Several animal species, […]

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New Anti-HIV Candidate Blocks Every Strain of HIV-1, HIV-2 and SIV

February 18, 2015

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Scientists Announce New Anti-HIV Agent

In a new study, researchers show that a new drug candidate blocks every strain of HIV-1, HIV-2 and SIV that has been isolated from humans or rhesus macaques, including the hardest-to-stop variants. Jupiter, Florida – February 18, 2015 – In a remarkable new advance against the virus that causes AIDS, scientists from the Jupiter, Florida […]

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Yale Study Reveals Anti-Inflammatory Mechanism of Dieting and Fasting

February 17, 2015

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Researchers Reveal Anti-Inflammatory Mechanism of Dieting and Fasting

New research from Yale University shows that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer’s disease. In their study, published in the February 16 online issue of Nature Medicine, the researchers described […]

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Engineered Insulin Stays in Bloodstream, Offers Better Diabetes Control

February 10, 2015

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Engineered Insulin Offers Better Diabetes Control

Engineers from MIT have developed insulin that can circulate in the bloodstream for hours, responding rapidly to changes in blood-sugar levels. For patients with diabetes, insulin is critical to maintaining good health and normal blood-sugar levels. However, it’s not an ideal solution because it can be difficult for patients to determine exactly how much insulin […]

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Scientists Identify Link between Inflammation and Type 2 Diabetes

February 6, 2015

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Researchers Identify Link between Inflammation and Type 2 Diabetes

A newly published study led by Yale University reveals the molecular mechanism by which insulin normally inhibits production of glucose by the liver and why this process stops working in patients with type 2 diabetes, leading to hyperglycemia. The findings are published February 5 in the journal Cell. “In the study, we set out to […]

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Potential Over-Treatment of Diabetes in Older Adults

January 14, 2015

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Study Shows Risk of Over Treatment in Older Diabetes Patients

New research from the Yale School of Medicine shows that aggressively controlling blood sugar with insulin and sulfonylurea drugs in older patients with multiple medical conditions could lead to over-treatment and hypoglycemia (low blood sugar). Published in the January 12 issue of JAMA Internal Medicine, the study found that many older diabetes patients received aggressive […]

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Researchers May Have Pinpointed a Strategy for Eliminating Latent HIV

January 8, 2015

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Study Shows Broad Immune Response May be Needed to Destroy Latent HIV

A newly published study shows promise as the future direction for the development of a therapeutic vaccine to clear HIV. A major barrier to finding a cure for HIV/AIDS is the presence of latent HIV in the cells of chronically infected individuals. But a team of Yale and Johns Hopkins researchers may have pinpointed a […]

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Yale Study Shows Metformin May be Safe for Patients with Kidney Disease

December 29, 2014

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Diabetes Drug May be Safe for Patients with Kidney Disease

A newly published study from Yale University reveals that metformin (the most popular treatment for type 2 diabetes) may be safer for patients with mild to moderate kidney disease than guidelines suggest. The new study is published by Yale investigators in the Journal of the American Medical Association (JAMA). For 20 years, metformin has been […]

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