Tuberculosis Resistance to Backup Drugs Increases

August 31, 2012

Biology

drug-resistant-tuberculosis

According to a new study, more than 40% of tuberculosis infections that are resistant to front-line antibiotic treatments have also become resistant to some common backup drugs. Efforts to control tuberculosis are being hindered by the emergence of multi drug-resistant (MDR) strains, making it harder to combat.

Researchers published their findings in the journal The Lancet. The MDR strains are resistant to rifampicin and isoniazid, especially in the developing world, where as much as 50% of tuberculosis cases have formed a resistance to these drugs. Alternative treatments are toxic and more expensive, and take a much longer time to fully cure the disease. Developing countries can’t afford the several billion dollars required to effectively combat the disease.

tuberculosis-medication

Broad-spectrum antibiotics called fluoroquinolones, amikacin, capreomycin and kanamycin are among the second-line drugs that the MDR strains are also resistant too. This extensively drug-resistant (XDR) tuberculosis indicates a trend towards infections that will eventually become untreatable.

The critical step involves preventing MDR tuberculosis from turning into XDR tuberculosis. In a recent survey of people diagnosed with MDR tuberculosis, 43.7% were infected with a strain resistant to at least one second-line drug while 6.7% were infected with a XDR strain.

The drug-resistant tuberculosis problem is man-made, because often the drugs used aren’t available or of poor quality. The key to solving it resides in early detection and quick treatment.

Diagnosing tuberculosis can take up to three months, during which the disease can still be transmitted. Treatment regimens must be tailored according to the type of strain an infected patient has contracted. Most of the countries with a high tuberculosis infection rate aren’t equipped for this, since it’s too expensive and logistically tricky to implement with so many infected patients.

However some countries, like Latvia and Estonia, have managed to stabilize or even reduce their levels of MDR tuberculosis by putting in place stringent control measures.

[via Nature]

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