Health

Wildfire Smoke Exposure in Early Pregnancy Adversely Affects Infant Monkey Behavior

Female Rhesus Macaque Monkeys and Infants

Female rhesus macaque monkeys and infants at the California National Primate Research Center at UC Davis. Studies on animals conceived during poor air quality due to the 2018 Camp Fire provide evidence for developmental effects of wildfire smoke. Credit: California National Primate Research Center

Infant monkeys conceived while their mothers were naturally exposed to wildfire smoke show behavioral changes compared to animals conceived days later, according to a new study from researchers at the California National Primate Research Center at the University of California, Davis. The work is published today (April 1, 2022) in Nature Communications.

The findings show the importance of timing in effects of smoke exposure on pregnancy and suggest a teratogenic, or developmental mechanism, said senior author Bill Lasley, professor emeritus of population health and reproduction at the UC Davis School of Veterinary Medicine and Center for Health and Environment.

“I think this will have an effect on future studies of exposures in pregnancy, because we’ll know when to look,” Lasley said. Existing studies of environmental exposures during pregnancy in humans are mostly retrospective, and women may not even realize they are pregnant until weeks into the first trimester, he said.

The Camp Fire, which began on November 8, 2018, provided a natural experiment in smoke exposure. It blanketed the Davis area, some 100 miles away, with smoke at the peak of breeding season for rhesus macaques housed in outdoor corrals at the California National Primate Research Center.

The 89 animals conceived around that time were born about six months later. They divide between 52 animals conceived on or before November 22, 2018, which were considered as “exposed” to wildfire smoke in their first trimester, and 37 conceived later which were not exposed.

John Capitanio, professor of psychology at UC Davis and a core scientist at the CNPRC, has been conducting standardized assessments on animals born at the Center for two decades. At about 3-4 months old, the young monkeys are assessed on a variety of cognitive and behavioral tests. While the number of animals conceived during the Camp Fire that were assessed was fairly small, they could be compared not only to each other (exposed vs. not exposed), but also to the historical data from hundreds of animals.

On assessment, the smoke-exposed infants showed increases in a marker of inflammation, a reduced cortisol response to stress, memory deficits, and a more passive temperament than other animals, Capitanio said.

“It’s a mild effect across a variety of domains of psychological function,” Capitanio said. The effects are consistent with those found in studies of prenatal exposure to air pollution, he said. Comparison between the groups and with animals born in other years shows that the results are not due to the timing of conception (earlier versus later in the breeding season).

Effect on fetal development

The findings suggest that some component of wildfire smoke can act as a teratogen, affecting fetal development, Lasley said. That component could be airborne hydrocarbons such as phthalates, which were found in the smoke plume from the Camp Fire.

Unlike other mammals, the placenta of primates such as humans and rhesus macaques produces hormones that support brain development through the adrenal system, he said.

“Since fetal adrenal glands are the source of cortisol and other steroids for neurologic development, which determines behaviors, a scenario of a placenta-adrenal-brain axis could be the causal pathway,” Lasley said.

Lasley is beginning a prospective study with women with implanted embryos as a result of in vitro fertilization, as the time of conception is exactly known if the women are incidentally exposed to wildfire smoke or other pollutants.

A previously published study on the same group of animals by Bryn Wilson, an OB/GYN resident at UC Davis Health in collaboration with Lasley and Professor Kent Pinkerton, UC Davis Center for Health and Environment, found a slight, but not statistically significant, decrease in the rate of live births in the affected cohort.

Reference: “Adverse biobehavioral effects in infants resulting from pregnant rhesus macaques’ exposure to wildfire smoke” by John P. Capitanio, Laura A. Del Rosso, Nancy Gee and Bill L. Lasley, 1 April 2022, Nature Communications.
DOI: 10.1038/s41467-022-29436-9

Additional authors on the paper are Laura Del Rosso, California National Primate Research Center and Nancy Gee, UC Davis Center for Health and Environment. The work was supported by grants from the NIH.

Share
By
University of California, Davis

Recent Posts

New RNA Tool Can Illuminate Brain Circuits and Edit Specific Cells

Editing technology is precise and broadly applicable to all tissues and species. Scientists at Duke…

October 5, 2022

Volcanic Super-Eruptions Are Millions of Years in the Making

While the magma supplying super-eruptions develops over long periods of time, the magma disturbs the…

October 5, 2022

Do Stars Remember Their Past? Study Sheds New Light on Old Theories of Stellar Evolution

A star's "childhood" shapes their stellar evolution.  From newborns to teenagers, stars in their "young…

October 5, 2022

Promising Anti-Cancer Drug Could Also Help With COVID

According to research conducted by Johns Hopkins Medicine, multiple variants of the SARS-CoV-2 virus can be…

October 5, 2022

Conventional Computers Can Learn To Solve Tricky Quantum Problems in Physics and Chemistry

Physicists prove that classical machine learning models can improve predictions about quantum materials. Quantum computers…

October 5, 2022

Dinosaur-Killing Asteroid Triggered Monstrous Global Tsunami With Mile-High Waves

Sixty-six million years ago a miles-wide asteroid struck Earth, wiping out nearly all the dinosaurs…

October 5, 2022