New discovery could lead to the development of drugs that halt disease progression and stop memory loss.
A scientific breakthrough in our understanding of Alzheimer’s disease has revealed changes to blood vessels in the brain, potentially presenting a path for developing new drugs to help fight the disease, according to University of Manchester research funded by the British Heart Foundation (BHF) and published on June 21, 2022, in Proceedings of the National Academy of Sciences (PNAS).
Alzheimer’s Disease is traditionally understood to be a disease of the brain cells, where a protein called Amyloid-beta (Aβ) accumulates and forms plaques. There is mounting evidence that the blood supply to the brain is also affected, however, it is unclear how this happens.
Now, scientists at the University of Manchester have found that a smaller version of the protein — called Amyloid-β 1-40 (Aβ 1-40) — builds up in the walls of the small arteries and reduces blood flow to the brain.
The surface of the brain is covered with small arteries, called pial arteries, that control the brain’s supply of blood and oxygen. If these arteries become narrowed for too long, the brain can’t get enough nutrients. This is one of the causes of memory loss seen in people with the disease.
How Aβ 1-40 Impairs Blood Flow
When the team looked at pial arteries of older mice with Alzheimer’s that produced too much Aβ1-40, they found that the arteries were narrower compared to those of healthy mice.
“To date, over 500 drugs have been trialled as a cure for Alzheimer’s disease. All of them have targeted the nerves in the brain and none of them have been successful. By showing exactly how Alzheimer’s disease affects the small blood vessels, we have opened the door to new avenues of research to find an effective treatment.”
Dr. Adam Greenstein
This narrowing was found to be caused by Aβ 1-40 switching off a protein called BK in cells lining blood vessels. When it is working normally, BK sends a signal which causes arteries to widen.
To confirm that Aβ 1-40 stopped BK from working properly, they soaked healthy pial arteries in Aβ 1-40 and measured the signals sent by the BK protein after one hour. Aβ 1-40 weakened these signals, which caused the arteries to narrow.
New Avenues for Alzheimer’s Treatment Development
The researchers now plan to investigate which part of Aβ 1-40 blocks the BK protein, so drugs to stop this from happening can be developed and tested as a much-needed treatment to prevent Alzheimer’s disease from progressing and save people the heartache of losing their memory.
Dr. Adam Greenstein, lead BHF-funded researcher and Clinical Senior Lecturer in Cardiovascular Sciences at the University of Manchester said: “To date, over 500 drugs have been trialed as a cure for Alzheimer’s disease. All of them have targeted the nerves in the brain and none of them have been successful. By showing exactly how Alzheimer’s disease affects the small blood vessels, we have opened the door to new avenues of research to find an effective treatment.”
Professor Metin Avkiran, Associate Medical Director at the British Heart Foundation said: “This research is an important step forward in our understanding of Alzheimer’s disease. More than half a million people in the UK are living with the condition, and that number is set to rise as our population gets older. These findings could lead to a desperately needed treatment for this devastating condition.”
Reference: “Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer’s disease” by Jade L. Taylor, Harry A. T. Pritchard, Katy R. Walsh, Patrick Strangward, Claire White, David Hill-Eubanks, Mariam Alakrawi, Grant W. Hennig, Stuart M. Allan, Mark T. Nelson and Adam S. Greenstein, 21 June 2022, Proceedings of the National Academy of Sciences.
DOI: 10.1073/pnas.2204581119
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6 Comments
I havre short memory l
loss, what is the remedy for me, please, i am 85 yrs young.
Kantharaj, try reducing your sugar intake and improving your sleep. Better sleep quality will allow your body to clean out all the plaques in the brain. Many things can be done to improve sleep, such as avoiding led or blue light 3 hours before sleep, not eating 3 hours before sleep, and practicing meditation. To help this, using a lot more high-omega-3 fish oil together with hemp extract will reduce inflammation and lower blood pressure.
I am chronically fatigued and my sleep is not deep. What do you recommend?
Alzheimers: coconut oil
Talk on Tedx talk said that a woman doctor brought her husband back from Alzheimers using 7 teaspoon of MCT oil a day. Only took a couple of weeks to see drastic improvements. Can start with coconut oil.
Be cautious with coconut oil and mct oil. I tried both and it gave me an irregular heartbeat. So much so that i thought I might have a heart attack. Once stopped, it returned to regular rhythm.