Groundbreaking Research Identifies Likely Cause of Alzheimer’s Disease – Potential for New Treatment

Alzheimers Dementia Brain Disease Concept

A study conducted on mouse models identified that a likely cause of Alzheimer’s disease is the leakage of fat-carrying particles transporting toxic proteins from blood into the brain.

A likely cause of Alzheimer’s disease offers a significant finding that offers potential new prevention and treatment opportunities for Australia’s second-leading cause of death.

Ground-breaking new Curtin University-led research has discovered a likely cause of Alzheimer’s disease, in a significant finding that offers potential new prevention and treatment opportunities for Australia’s second-leading cause of death.

The study, published in the prestigious PLOS Biology journal and tested on mouse modelsidentified that a probable cause of Alzheimer’s disease was the leakage from blood into the brain of fat-carrying particles transporting toxic proteins. 

Lead investigator Curtin Health Innovation Research Institute (CHIRI) Director Professor John Mamo said his collaborative group of Australian scientists had identified the probable ‘blood-to-brain pathway’ that can lead to Alzheimer’s disease, the most prevalent form of dementia globally.

“While we previously knew that the hallmark feature of people living with Alzheimer’s disease was the progressive accumulation of toxic protein deposits within the brain called beta-amyloid, researchers did not know where the amyloid originated from, or why it deposited in the brain,” Professor Mamo said.

“Our research shows that these toxic protein deposits that form in the brains of people living with Alzheimer’s disease most likely leak into the brain from fat carrying particles in the blood, called lipoproteins.”

“This ‘blood-to-brain pathway’ is significant because if we can manage the levels in blood of lipoprotein-amyloid and prevent their leakage into the brain, this opens up potential new treatments to prevent Alzheimer’s disease and slow memory loss.”

Building on previous award-winning research that showed beta-amyloid is made outside the brain with lipoproteins, Professor Mamo’s team tested the ground-breaking ‘blood-to-brain pathway’ by genetically engineering mouse models to produce human amyloid-only liver that makes lipoproteins.

“As we predicted, the study found that mouse models producing lipoprotein-amyloid in the liver suffered inflammation in the brain, accelerated brain cell death, and memory loss,” Professor Mamo said.

“While further studies are now needed, this finding shows the abundance of these toxic protein deposits in the blood could potentially be addressed through a person’s diet and some drugs that could specifically target lipoprotein amyloid, therefore reducing their risk or slowing the progression of Alzheimer’s disease.”

Alzheimer’s WA Chairman Adjunct Professor Warren Harding said the findings may have a significant global impact for the millions of people living with Alzheimer’s disease.

“Having universities like Curtin working with the pharmaceutical industry is important if we are to tackle this devastating disease,” Mr. Harding said.

“In Australia, approximately 250 people are diagnosed with dementia daily, adding to the staggering half a million Australians who are already living with dementia. Without significant medical advances like the breakthrough Professor Mamo’s team has made, it is estimated that the number of Australians living with dementia will exceed one million by 2058. This has a significant impact on families, carers and communities.”

Professor Mamo and his research team’s previous research in this area was awarded the NHMRC-Marshall and Warren Award for the most innovative and potentially transformative research.

Currently, the team is conducting a clinical trial, the Probucol in Alzheimer’s-clinical trial, which is based on previous findings that a historic cardiovascular agent lowers lipoprotein-amyloid production and supports cognitive performance in mice.

For more on this research, see Protein Made in the Liver May Cause Alzheimer’s Disease in the Brain.

Reference: “Synthesis of human amyloid restricted to liver results in an Alzheimer disease–like neurodegenerative phenotype” by Virginie Lam, Ryusuke Takechi, Mark J. Hackett, Roslyn Francis, Michael Bynevelt, Liesl M. Celliers, Michael Nesbit, Somayra Mamsa, Frank Arfuso, Sukanya Das, Frank Koentgen, Maree Hagan, Lincoln Codd, Kirsty Richardson, Brenton O’Mara, Rainer K. Scharli, Laurence Morandeau, Jonathan Gauntlett, Christopher Leatherday, Jan Boucek, John C. L. Mamo, 14 September 2021, PLOS Biology.
DOI: 10.1371/journal.pbio.3001358

31 Comments on "Groundbreaking Research Identifies Likely Cause of Alzheimer’s Disease – Potential for New Treatment"

  1. The British Medical Journal ‘The Lancet’, published a study in 1994, that was picked up by the New York Times, that identified the annual flu shot, as the reason for the onset of Alzheimer’s Disease, in later life. They said that the aluminum in the shots breached the brain barrier, and that repeated doses cumulatively degenerated brain function. That study of course has been scrubbed from the archives of both the Journal and the Times.

    • It’s been “scrubbed” as you state, because it was found to be completely incorrect as it assumed in a very small study that the flu shot correlated with the onset of alzheimer’s. This was found not to be the case whatsoever and was a dangerous assumption so it was removed and for many years while it was still widely available came with a warning that the study was funded by a group selling alternative “cures” for flu, and so had an interest in suppressing use of the vaccine.

  2. A very informative study. The summary is too brief and needs to be included some infirmation on preventive measures fir the interest and benefit of common reader

  3. A conflation between correlation and causation in medical research can lead to confusion in interpretation.

  4. This is great research. But the intrusion of faulty amyloid proteins into brain tissue via lipids may have as much (or more) to do with lymphatic circulation than blood circulation. There is both a lymphatic-brain barrier at the meninges and a glymphatic system discovered only a few years ago in addition to the well known blood-brain barrier.
    “Frontiers | CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges | Pharmacology”

  5. “…potentially be addressed through a person’s diet and some drugs that could specifically target lipoprotein amyloid…”
    And those foods that are good/bad are ?

  6. Aluminum in brain has always been implicated in Alzheimers. How it gets there is the issue. Sodium Fluoride (not Calcium Fluoride) is the main documented pathway. As per previous comment above, aluminum is also directly added as a vaccine adjuvant to promote general inflammation. Detox with cilantro (slow).

    • Steve Barnhaus | April 1, 2022 at 8:09 am | Reply

      No, aluminum has not “always” been linked to Alzheimer’s. That was a short-lived hypothesis formulated and debunked in the 1970s. Try to catch up.

  7. This must have been written by a bot. The grammar is trash.

  8. Thank you for the research and fighting the fight against this devastating disease. My Mom suffered with it for years. It broke my heart to watch her decline. My hope and prayers are with you that we can fight and eradicate this death sentence disease.

  9. If the flu shot was responsible for Alzheimer’s it would follow that the countries that received the most flu shots in the world would have the highest level of Alzheimer’s. You may be interested to know that the highest levels of Alzheimer’s in the world are in turkey and Lebanon. Neither of which have any significant amount of flu shots. The highest level of flu shot vaccinations in the world is South Korea. It is important to note that they have very low levels of dementia and Alzheimer’s. The opposite of love is not hate. The opposite of Love is fear. Hitler did not hate the Jews, Hitler feared the Jews. Stalin did not hate five million Russians, he feared the Russians he killed. Don’t make the world a more fearful place. Try to make the world a more loving place.


  11. This is huge news, but the title is misleading. The cause wasn’t identified. The mechanism was. Identifying *why* this happens would be the next huge step after we do the stopgap work of figuring out a preliminary treatment.

  12. Interesting to note that Alzheimers has been called “diabetes 3” by some researchers.It would be wise to look at things that affect blood sugar,insulin levels and liver function. Sugar and HFC would be big players in that,causing inflammation and fatty liver.

  13. Do cholesterol drugs like Lipotor, which effect the liver, help Alzheimers disease or cause more problems with dementia/Alzheimers??

  14. If the state of NY receives billions of dollars year such as the 250 billion dollar budget put forth for the first half of the fiscal year 2021, and most probably another 250 billion for the remaining 7 months of the reporting period ending 3/31/2022, what is it that the citizens can see as feasible evidence of the gross expenditure, especially the approximate 890 million dollars extra sent to NY from the president,to pay for another eavesdropping device and high density transmissions from a place where more incompetent fools keep subjects under anesthesia and use them as experimental Guinea pigs so they really small minded and racist little shrinks can kill more patients and transmit high quality xrays to nes Scotlands brain computer interface and then have more darkness
    in an already near cbr density of near tritium grade water for the cloning experiments to continue as planned under the colorful things not seen by most but known as remote controll through broadband transmissions from the places Aldrich likes to call his pool room. Full color videos of his favorite pastime of clueless conversations and real time management systems of death and extinguishment, especially of the poor and in accordance with another idiot’s policy ulof term8nsyion if freedom named donald cameron look it up, Eric ypod… ok…

  15. Not mentioned what lipoproteins exactly are the carriers. As you know there are several classes with different functions.

  16. Joseph Lloyd woyczik | September 19, 2021 at 6:24 am | Reply

    Well I got world war 4 news for you simply electric magnetic pulse , oar , jails and prisons and hospitals that have an icu

  17. science and politics have unfortunately become indistinguishable. blame the 1000 bs sci-fi stories put forth before this one_ which might be factual?. . maybe one could hypothesize from this story a nonfat non protein diet must be enforced by govt for the greater good and to prevent others from paying for your dementia? and Australia is the new testing ground for the covid dictatorship. just saying… will we see meat and dairy become illegal? “for the greater good”..if so we can be sure this story is politics not science..

  18. There seems as well to be a genetic component to Alzheimer’s that seems unaccounted for. I just recall two women whom I knew and loved, the same age, say 60, and complexion and build, both suddenly dead of the illness, when two years before both seemed normal. They lived blocks apart in California near the Pacific. I wondered what they had in common? As to genetics, friends with parents afflicted fear their own demise.

  19. My Mother died of dementia at 93. She never had a flu shot. She had a polio vaccine as a young woman because her brother contracted & survived polio. Please don’t exploit such irresponsible publications. Just because it’s online does not make it true.

  20. Is the immune system involved in any of this? An over-active immune system could damage the barrier and its function, allowing the poisoning.

  21. Captain Hindsight | September 19, 2021 at 12:48 pm | Reply

    Every drug based on amyloid placque reduction in the brain has been an unmitigated failure. Time to start thinking out of the box and look at those that have achieved clinical success with patients and not mouse doctors. Look to Dr. Bredeson’s Protocol.

  22. Check on :” Vitamin K2 protects against Aβ42-induced neurotoxicity…”
    Just take K2mk4 beside your K2mk7. Mk4 is passing blood brain barrier+.
    One day hopefully we will finally discover K2 again.
    Beside it is best for Covid and vax. side dish.

  23. My opinion on Alzheimer’s disease

    Itss sad not a disease, it’s not caused by diet or any normal food.

    It is in my opinion, by renegade thought to be humans, who like power over others and enjoy exercising the privelege of oppressing others without a right to do so.

    They haa as ve an ability that was meant by GOD THE CREATOR BUT WHICH WAS MEANT TO BE USED TO MINISTER TO YHOSE IN NEED.

    The persons who have this ability, called OPEN EYES, which has been MISSUSED to oppress others.

    An example of this ability is seen in the Holy Scriptures where if was misused by two groups of people.

    Ba’alam of Peor who used his ability to Curse with his gift in order to gain power and wealth.

    Korah and his family used this gift to oppose Moses.

    This is I believe what happens to So Called Alzheimer’s disease, and probably in order to take. Personal wealth and to just enjoy doing so in a way, in which they do so, from inside the person who is said to have Alzheimer’s.

    You can often see, the person with Alzheimer’s disease, exhibits likes and dislikes and familial hate that obviously comes from childhood distress from what may result from more attention accomplished on one child who is often the Alzheimer’s patient and the dislikes may be seen to come from a second sibling who was with one parent because the parents were separated for a long time for a reason which is unavoidable.

  24. Will .. you are correct that the opposite of love and is fear.. however Hitler didn’t fear Jews, he himself was born one by Jewish parents, who gave him up for adoption. It was his insecurity and resentment for being abandoned by his them as if if unwanted trash that bore his anger towards Jewish people and served as an ax to grind unable to fathom how one could disregard and throw away ones child.

  25. FUNGUS such as systemic candidiasis. Cause of sooooo many health problems and still not understood or just denied.

  26. So how is this related to it being Type 3 Diabetes? And why do Medium Chain Triglycerides reverse cognitive decline in Alzheimers sufferers?

  27. WOW Willie T, such an awesome comment about love, hate and fear.

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