A Drug Used to Treat Deadly Coronavirus Infections in Cats May Be an Effective Treatment Against COVID-19

Cat Veterinarian

In a search for COVID-19 treatments, researchers pursue a drug used on cats.

University of Alberta researchers worked with SLAC X-ray scientists to explore the potential of a feline coronavirus drug that may be effective against SARS-CoV-2.

Researchers at the University of Alberta have shown that a drug used to treat deadly coronavirus infections in cats could potentially be an effective treatment against SARS-CoV-2, the virus behind the global coronavirus pandemic. The results were published in the journal Nature Communications.

The study, which was aided by scientists at the U.S. Department of Energy’s SLAC National Accelerator Laboratory, paves the way for human clinical trials, which should begin soon, said Joanne Lemieux, a professor of biochemistry at the University of Alberta and the study’s senior author.

Joanne Lemieux

Joanne Lemieux and a team at the University of Alberta found that a drug used in cats may help treat SARS-CoV-2 infections. Credit: Image courtesy Joanne Lemieux

“This drug is very likely to work in humans, so we’re encouraged that it will be an effective treatment for COVID-19 patients,” Lemieux said, although the clinical trials will need to run their course before anyone can be sure that the drug, a protease inhibitor called GC376, is both safe and effective for treating COVID-19 in humans.

In cats at least, GC376 works by interfering with a virus’ ability to replicate, thus ending an infection. Derivatives of this drug were first studied following the 2003 outbreak of severe acute respiratory syndrome (SARS), and it was further developed by veterinary researchers who showed it cures fatal feline affliction.

Lemieux and colleagues at the University of Alberta first tested two variants of the feline drug against SARS-CoV-2 protein in test tubes and with the live virus in human cell lines, then crystallized the drug variants in conjunction with virus proteins. Working with Silvia Russi, a crystallographer and beamline scientist for the Structural Molecular Biology program at SLAC’s Stanford Synchrotron Radiation Lightsource (SSRL), the researchers determined the orientation of the cat drug as it bound to an active site on a SARS-CoV-2 protein, revealing how it inhibits viral replication.

“This will allow us to develop even more effective drugs,” Lemieux said, and the team will continue to test modifications of the inhibitor to make it an even better fit inside the virus.

Aina Cohen, a SLAC senior scientist and co-division head of Structural Molecular Biology at SSRL, said she was excited by the drug’s effectiveness and by SSRL’s ability to help out. “Until an effective vaccine can be developed and deployed, drugs like these add to our arsenal of COVID-19 treatments,” she said. “We are thrilled to learn of these important results and look forward to learning the outcome of clinical trials.”

Reference: “Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication” by Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas and M. Joanne Lemieux, 27 August 2020, Nature Communications.
DOI: 10.1038/s41467-020-18096-2

The research was funded by the Canadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada. Extraordinary SSRL operations were supported in part by the DOE Office of Science through the National Virtual Biotechnology Laboratory, a consortium of DOE national laboratories focused on response to COVID-19, with funding provided by the Coronavirus CARES Act. SSRL is a DOE Office of Science user facility. The Structural Molecular Biology Program at SSRL is supported by the DOE Office of Science and by the National Institutes of Health, National Institute of General Medical Sciences.

12 Comments on "A Drug Used to Treat Deadly Coronavirus Infections in Cats May Be an Effective Treatment Against COVID-19"

  1. Informative post. Thanks to https://scitechdaily.com

  2. I hate Animals being used for testing on anything. All Animals monkeys, cats,dogs, rats, rabbits, pig’s. It all needs to come to an end! Poor Animals being treated like objects like their lives don’t matter & It does. We need to find other ways for testing!

    • Scharmella, did you even read the article? This isn’t an article about animal testing. This article said a drug ALREADY BEING USED AS A TREATMENT FOR COVID IN CATS may in fact work as a treatment for Covid in humans, too! Hellooooo.

  3. Since this s actually taken from anmal Drugs,it could be the thing needed to beat the Virus, if after all the tests are done and it is proven safe, I see no reason not to have a Vaccine like this!

  4. If my cat comes down with covid19, will it be able to get treated with the drug?

  5. I’m not a fan of animal testing either. I’ve been a Veterinary Technician for 18years and have seen the animals used for research. Honestly, they are treated well and many are very happy.
    Unfortunately, without animal testing, our advancement in medicine would be much slower. If you want to stand up for something, demand the animals get a home. Instead of trying to stop experimentation all together, demand the animals get adopted and not killed after the experiment has concluded.

  6. What took you so long? It’s common sense that this should have been looked at right away. Morons.

  7. What kills me is that there was a drug to cure cats for years and no one thought to see if it would work for humans.

  8. I mean, it’s not like it’s a commercially available drug for cats. Until last year, FIP was considered 100% fatal in all cases. Then promising research began to come out of some of these studies (most of which are on pet cats in their own homes, fwiw, enrolled by their desperate owners) but it’s not like your cat can get ANY treatment other than palliative care unless you can find and afford black market remdesivir.

  9. Spirituality Awakening | September 21, 2020 at 5:16 am | Reply

    WOW… It’s great… 🙂

  10. Miranda. Why are you calling them morons? What life saving things have you done lately? Trumper

  11. Understand the concern for animal testing, but this drug sounds really promising if it’s already being used to save our favorite feline people.

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