14 Adult Patients in Long Term Functional Remission of HIV After Treatment

14 Adult Patients in Long Term Functional Remission of HIV

A newly published study reports on fourteen adult patients in long term functional remission of HIV seven years after being taken off early antiretroviral treatment.

The work published today in PLoS Pathogens describes the control of HIV infection after early treatment of 14 patients who have been off therapy for 7.5 years (the cohort ANRS EP47 VISCONTI). This work suggests on a larger and durable scale what the functionally cured “Mississippi baby” case potentially indicates: that early therapeutic intervention may be instrumental in HIV control and has important implications for HIV cure research.

It is known that following acute infection, HIV establishes viral reservoirs in long-lived cells which allow its persistence even after prolonged treatment. As a consequence, viral replication readily restarts at pretreatment levels upon treatment interruption in most patients.

However, few patients treated very early in primary infection are able to control infection after treatment interruption. The initial observation of patients controlling HIV was made in France by Dr Laurent Hocqueloux (Orleans-La Source Hospital) and in the ANRS CO06 PRIMO cohort (this cohort is a long term survey of newly infected patients). The ANRS decided in 2009 to set-up and fund a multidisciplinary team of researchers and to assemble a cohort of such patients to characterize this phenomenon. The ANRS EP 47 VISCONTI cohort (Viro-Immunologic Sustained COntrol after Treatment Interruption) is a group of 14 patients who have maintained virological control of their HIV infection for a median time of 7.5 years after the interruption of antiretroviral therapy. All these patients were diagnosed during primary infection and were immediately treated (within ten weeks after infection) with antiretroviral drugs, for a median time of three years before treatment discontinuation. The ANRS EP 47 VISCONTI study is coordinated by Prof. Christine Rouzioux (Necker Hospital and University Paris Descartes, Paris), member of the initial team who identified HIV 30 years ago, and Dr. Asier Sáez-Cirión (Institut Pasteur, Paris), senior researcher in the lab of HIV co-discoverer and Nobel Prize Laureate Pr. Françoise Barré-Sinoussi.

There is an immensely valuable store of knowledge to be gained from analyzing the immunological and genetic characteristics for these patients. Preliminary data presented last year by Charline Bacchus (Pitié-Salpêtrière Hospital, Inserm Unit U945) at the XIXth International AIDS conference in Washington DC have shown that the ANRS EP 47 VISCONTI patients showed very low levels of HIV reservoirs, similar to those of natural HIV Controllers (patients who never received any treatment, remain asymptomatic and spontaneously control viral replication for many years)*. The results published in PloS Pathogens today show that the number of infected cells circulating in the blood of some of these “post-treatment controllers” keeps decreasing in the absence of treatment over the last four years. The shrinking of viral reservoirs while maintaining controlled viremia in these individuals closely match the definition of “functional” cure. Pr. Rouzioux explains “Early treatment in these patients may have limited the establishment of viral reservoirs, the extent of viral mutations and preserve immune responses. A combination of those may contribute to control infection in post-treatment controllers”.

A study presented at last week´s Conference on Retroviruses and Opportunistic Infections (CROI) in Atlanta showed that a baby infected with HIV in utero who was treated within 30 hours of birth and for 18 months had been able to control infection for 6 months.

“As in the case with the “Mississippi baby”, early treatment initiation does not allow us to evaluate whether the VISCONTI post-treatment controllers might have naturally achieved control of infection”, said Sáez-Cirión. “However, most of them do not exhibit the favorable genetic background found in natural HIV controllers and do not develop the same immune responses associated with control of infection in the latter. Moreover, whereas natural HIV controllers typically start controlling infection in primary infection, most post-treatment controllers were strongly symptomatic during this period, with levels of virus in the plasma high and similar to those of patients who will not control infection”.

Although most patients will not be able to control HIV, the data presented in the ANRS EP 47 VISCONTI and the Mississippi study strongly support early treatment initiation and may hold important clues for the development of a strategy to cure HIV or at least, induce a long-term control without the need of antiretroviral treatment. “Current efforts are focused in understanding why only a fraction of patients treated in primary infection are able to control infection and what are the mechanisms responsible for viral control in these post-treatment controllers. A European cohort constituted of Post-treatment Controller patients will start in the next few months, coordinated by the ANRS”, says Pr Jean-François Delfraissy, Director of the ANRS.

Publication: Asier Sáez-Cirión, et al., “Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study.” (2013) PLoS Pathog 9(3): e1003211. doi:10.1371/journal.ppat.1003211

Source: Institut Pasteur

Image: Black and White HIV Cell from Shutterstock

5 Comments on "14 Adult Patients in Long Term Functional Remission of HIV After Treatment"

  1. Kate morrison | May 31, 2014 at 2:53 pm | Reply

    Goodday
    My name is Kate Morrison from united states, i am here to thank DR OVIA the powerful spell caster that rescue me from HIV AIDS. I was diagnosed of this disease in the year 2012, and because of this, i was very unhappy with my life, and i went into research on how i can get cured, i contacted alot of spell casters and none of them could help me rather thay scammed me and took away my money without helping me. All this period of my life, i was sad and unhappy so one day as i was in the internet a decided to sign in a friend guestbook, only for me to see was a testimony of a lady on how she was helped by DR OVIA, so i was confused to contact him at the moment because i didn’t want to be scammed again but after one week, i decided to contact him, so when i contacted him, he assure me that he will help me and i told him that many spell casters has also told me this but they all scammed me, he told me not to worry that he is going to help me, So i believe in him because all i wanted was to be cured, so he prepared a healing spell for me and told me to wait fot just 24 hours, after 24 hours, i went to the hospital for test and to me happines the test stated that i was cured from the disease.. This gladens my heart and everybody in the hospital was surprised even the Medical Doctor, So viewers DR OVIA is a God Gifted man and can help you to cure all types of sickness like HIV AIDS, CANCER, PILE, Kidney problem and lot’s more. You can contact him through his email on ([email protected]). For more details you can reach me on my ID [email protected]

  2. He that work and never ask for anything thanks dr udo for good work for healing my brother for HIV sickness he was very sick for a year + and my daddy have spend so much money on medical care and drug he have being taking to some many place for healing… even different pastor have pray for him it get worse every 6hous the man that heal with 45mins is here the man that the lord god have giving the power to put every thing in place the man that give a word and never fail my kid brother was just chatting one day when he see this post of jack about the curing of HIV virus by dr udo he run to my daddy and tell him about the man my daddy decided to call him and confirm it if it is true about the cure the man just assure him about his work that the great power of is for father and his gods cure any disease include HIV/AID, Ebola, Rota virus, Smallpox ,Hepatitis well we have hope on him which we give a try to after five days my big brother started getting better as am write this comment his is at work now what a miracle…..

  3. Laura Zamora | July 4, 2014 at 6:55 am | Reply

    !!! How To Get Your BEST CURE TO YOUR HIV AND AID Immediately !!!

    My names Laura Zamora, I am from florida usa am here to give my testimony about a doctor who help me in my life. I was infected with HIV virus in the year of 2009,i went to many hospitals, churches for cure but there was no solution out, so I was thinking how can I get a solution out so that i cannot loose my life, I lost everything I have my husband run away from me and also took my children along because of my sickness. One day I was in the river side thinking the next step to take if it is to jump into the river so that I can loose my life totally or just think where I can go to get solution. so a lady walk to me telling me why am I so sad and i open up all to him telling her my stories, she told me that she can help me out that?s the reason she normally come here to help people so that they can be cured because she was into this problem before, she introduce me to a doctor how cast spells for people and gave me he number and email so i called him and also email him.so i gather all my faiths and put in all interest to contact him through his Email address at ([email protected]) , so after i have mailed him of helping get my disease cured, i respond to me fast as possible that i should not be afraid, that he is a truthful and powerful doctor which i firstly claimed him to be. So after all set has been done, he promise me that i will be healed but on a condition that i provide him some items and obeyed all his oracle said. I did all by accepting his oracle fact and only to see that the following week Dr.Ben mail me on my mail box that my work is successfully done with his powers, i was first shocked and later arise to be the happiest woman on earth after i have concluded my final test on the hospital by my doctor that i am now HIV- Negative. My papers for check are with me and now i am happy and glad for his miraculous help and power.With these i must to everyone who might seek for any help, either for HIV cure or much more to contact him now at these following email now,Email: ([email protected]) ” sir thank you so much for your immediate cure of my disease, i must say for curing my disease, i owe you in return. Thanks and be blessed sir. My name is Anabel James from UK and His Email address is: ([email protected]) or you can call him via his cell phone number on +2348133873774

  4. Douglas dashy | July 6, 2014 at 9:37 am | Reply

    My name Douglas dashy from Oxford,UK …HIV has been ongoing in my family for long..I lost both parents to HIV and it is so much pain have not been able to get over.As we all know medically,there is no solution or cure for HIV and the cost for Medication is very expensive..Someone introduced me to a man(Native Medical Practitional)in oxford..I showed the man all my Tests and Results and i told him have already diagnosed with HIV and have spent thousands of dollars on medication..I said i will like to try him cos someone introduced me to him..He asked me sorts of questions and i answered him correctly..To cut the story short,He gave me some medicinal soaps and some herbs(have forgot the name he called them) and he thought me how am gonna use them all..At first i was skeptical but i just gave it a try..I was on his Medication for 2 weeks and i used all the soaps and herbs according to his prescription.. that he will finish the rest himself..and i called him 3 days after, i arrived and i told him what is the next thing..he said,he has been expecting my call.. he told me to visit my doctor for another test..Honestly speaking,i never believe all he was saying until after the test when my doctor mention the statement that am, HIV negative and the doctor started asking me how do i do it….Am telling this story in case anyone may need this man his email is: [email protected] or call him now at +2348158847627

  5. MAY GOD BLESS TOKUBO FOR HIS KIND HELP TOWARDS HUMANITY. Hello Friends i am so glad to write this article today to tell the world how Dr Tokubo cured my Hiv virus that have been in body since five years ago, ever since then my life has been in complete,i have used so many drugs that was prescribed to me by several doctors,but it didn’t cure my Hiv VIRUS neither did it reduce the pain, i was checking for solution on the internet then miraculously came across Dr Tokubo the powerful herbalist that cure Hiv INFECTION,then i contacted his email, i explained everything to him and he prepared a herbal cure and send it to me that was how i got cured from Hiv disease totally after receiving his herbal medicine, so my friends viewers why waiting and be suffering with this Hiv virus when there is someone like Dr Tokubo that can cure any disease HIV/ CANCER/ HEPATITIS C VIRUS,HERPES VIRUS,ALS VIRUS. you can contact him via google search engine by searching for his name on google. just search to priest tokubo on google

Leave a comment

Email address is optional. If provided, your email will not be published or shared.