New Drug Could Help Stop Depression, Anxiety, Brain Injury, and Cognitive Disorders

The researchers showed that the systemic administration of the new drug alters neurobehavior in mice, reducing anxiety-like behavior. It also provides a promising landscape for future studies to assess whether the drug could help combat stress, anxiety, depression, addiction, cancer, and neurodegeneration.

The preclinical drug works by inhibiting the kinase Cdk5 which is found in mature neurons. Cdk5 has long been linked to neuropsychiatric and neurodegenerative disorders, but prior inhibitors have largely failed to cross the blood-brain barrier and enter the brain.

A new preclinical drug reported by James Bibb, Ph.D., and colleagues has the potential to combat depression, brain injury, and cognitive disorders.  The drug, which is notable for being brain-permeable, works by inhibiting the kinase enzyme Cdk5.

Cdk5 is an important signaling regulator in brain neurons. Over three decades of research, it has been linked to neuropsychiatric and degenerative disorders such as Alzheimer’s and Parkinson’s. Knocking out the enzyme in mice makes them more resilient to stress, improves cognition, protects neurons from stroke and brain trauma, and slows neurodegeneration.

While Cdk5 inhibitors may offer potential therapeutic benefits and new ways to study basic brain function, previous first- and second-generation anti-Cdk5 compounds largely get blocked at the blood-brain barrier, which restricts solute movement from the blood to the extracellular fluid of the central nervous system. So far, no Cdk5 inhibitor has been authorized for the treatment of any neuropsychiatric or degenerative condition.

James Bibb, co-author of the study. Bibb holds the Dr. Champ Lyons Endowed Chair in General Surgery at the University of Alabama, Birmingham, and is a senior scientist at the O’Neal Comprehensive Cancer Center.

Bibb and colleagues now report details of their anti-Cdk5, brain-permeable compound, 25-106. They also show that systemic administration of 25-106 alters neurobehavior in mice, reducing anxiety-like behavior.

“As perhaps the first robust systemic inhibitor, 25-106 represents an exciting and expandable and translatable pharmacological tool to study the function of Cdk5 activity in wild-type animals,” said Bibb, a professor in the University of Alabama at Birmingham (UAB) Department of Surgery. “Achieving systemic applicability may be considered a step forward toward the testing of Cdk5 inhibitors to treat neuropsychiatric and neurodegenerative diseases. This provides a promising landscape for future studies to assess the effects of brain-permeable Cdk5 inhibitors to combat stress, anxiety, depression, addiction, cancer, and neurodegeneration.”

The study, “Systemic administration of a brain permeable Cdk5 inhibitor alters neurobehavior,” is published in Frontiers in Pharmacology.

In the paper, researchers describe the synthesis of the aminopyrazole-based inhibitor, and they used molecular modeling to show that 25-106 appears to occupy the same hydrophobic binding pocket as the well-established Cdk5 inhibitor roscovitine.

They showed that 25-106 inhibited Cdk5 activity in a dose-dependent manner in brain striatal slices ex vivo and that it also penetrated the brain after systemic administration in mice to inhibit Cdk5 in vivo. They measured the pharmacokinetic and pharmacodynamic parameters of 25-106 in blood plasma and the brains of mice, and the off-target distribution of 25-106 in the liver and kidneys.

Mice given systemic 25-106 showed modulated neurobehavior in the open field maze test and the tail suspension test, anxiolytic changes that have previously been linked to Cdk5 knockout mice.

They found that 25-106 is a non-selective inhibitor of both Cdk5 and another cyclin-dependent kinase, Cdk2, but note that very low levels of Cdk2 are found in the brain. However, any off-target or toxic effects of systemic inhibition of Cdk2 by 25-106 remain unknown.

According to Bibb, three teams of researchers were involved in this study, including UAB Marnix E. Heersink School of Medicine Department of Surgery neurobiologists Bibb, Alan Umfress, and Ayanabha Chakraborti, as well as Florian Plattner of Neuro-Research Strategies, Houston, Texas. Also involved were UAB Department of Pharmacology and Toxicology researchers Kevin J. Ryan and Edward P. Acosta. The third group was composed of University of Nebraska Medical Center medicinal chemists Sarbjit Singh, Yogesh Sonawane, Jayapal Reddy Mallareddy, and Amarnath Natarajan.

Support came from National Institutes of Health grants MH116896, MH126948, CA127297, and NS061788.

Reference: “Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior” by Alan Umfress, Sarbjit Singh, Kevin J. Ryan, Ayanabha Chakraborti, Florian Plattner, Yogesh Sonawane, Jayapal Reddy Mallareddy, Edward P. Acosta, Amarnath Natarajan and James A. Bibb, 12 May 2022, Frontiers in Pharmacology.
DOI: 10.3389/fphar.2022.863762

Alzheimer'sBrain InjuryDepressionDrugsParkinson's DiseasePopularUniversity of Alabama
Comments ( 245 )
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  • Stacey

    How does one get into the test group?

    • Bonita Adamczyk

      How does one get into the test group, please?

      Thank you,
      Bonita

      • Ella Ward

        Hello Bonita, I have been in touch with the Research Team for few days and I am getting better

      • Guido

        Contact James Bibb. Tell him Guido sent ya..

    • Steal the Stop

      Everybody trying to enroll in clinical trials for this drug is wasting their time. Depression is a symptom of underlying issues. In this case stupidity.

  • Zarina Damonse

    Sounds amazing. Wish I could be part of a human clinical trial.. Best wishes to all who will get this drug

  • Tammy Padgett

    Yes it would be nice to know if it would work on me.

    • Scammers die

      You lie. Hope you get mouth cancer for the evil you are spreading

  • Lloyd Briones

    I’d like to be in the preclinical trials.

    • Ella Ward

      I have been admitted and the results are amazing, I recommend this new Drugs to everyone who needs help

  • Ryan Aston

    Is that Matt aka DarkViperAU that they used for their blurry drug holding image???

  • nicole neuhaus

    Hello, I would like to be part of your clinical trial for treatment of depression.
    Thank you,
    Nicole

  • Dr. Mekah Gordon

    Sounds fascinating and hopeful for those suffering a plethora of psychosymptomatic occurrences.

    • Lost souls

      Down the Rabbit hole we go

  • Antonio

    I would like to have some more information about it, I have this condition, lost memory 4 years ago.

    • Steal the Stop

      Antonio you might not remember me, but you owe me $500. And ya, it was like 4 years ago so with the intrest…

  • Boxer Bob

    Because of the shenanigans over the past two years, I have lost confidence in science, medicine, pharma, and politicians. All have caused depression and now they have the solution? Are you kidding me?

    • Actual boxer with a working brain

      In case anyone wasn’t sure, “Boxer Bob” is an idiot who doesn’t understand how vaccine research during a serious pandemic works. Plus he probably doesn’t have enough of an immune system left to survive a actually boxing match. Lol

      • Actual boxer with a working brain

        *actual* excuse Google’s voice to text function

  • Rajeshree

    Can this drug help with Dementia

  • Brad

    I need this

  • William

    How does someone volunteer as test subject for this study. I live with these n other disorders. Depression being the central culprit, exacerbating the box issues as well as c-ptsd. Currently I use CBT actions as well as medication
    The medication barely does anything, but is better than without. I’m not a huge fan of big business pharmaceuticals, but the alternatives seem lack lustre at best. I’m in Canada though. Would it still be possible, to participate-ive done just about any other hardcore drug n survived o.d’s so I’m open to experimenting. Who knows, maybe it’d do something

    • Me

      Yeah, who knows. Maybe it’ll do something…something bad.
      Unless you’re dying why in the world would you want to ever be a guinea pig?

      • John Dean

        Have depression stress and anxiety 30+ years. Need help desperately!!

    • Dr.Mom

      Have you tried Cocaine? I would recomend you start with that.

  • Jeannette Deever

    Sounds like this,could be life changing/life saving for many people

  • Lisa Rogers

    ANOTHER DRUG!!!
    WE live in a world where the Pharmaceutical companies are making billions on keeping people sick!!!

  • Deborah

    I live in CT plus get Yale involved in this breakthru. I would definitely be a candidate for a clinical trial.

    • Trump Cuck

      This is Yale. You are a chump. Give me your money. You probally a Trump follower sucker

  • Katherine Ann Kennedy

    I have recently been diagnosed with Parkinson’s disease. I would like to volunteer for the clinical trials

  • Me

    Give Brandon a whole handfull!

    • Your Moms wooden leg

      Wow didn’t know we had a comedian on here. You should hang around some smart people and get out the trailer

  • Elizabeth Carter

    I would be thrilled to be part of the human trials of this drug. This drug sounds, quite frankly, like an amazing possibility for so many of us!

    • Captain underpants

      Beth sweetie, it’s a bs story ad. If it sounds ro good to be true prob is and it would be major news not some dumb article. Don’t click links, and don’t answer calls from “unknown” you people worry me, God bless but there is no God so just “bless”

  • Leslie Fuller

    I have a son that would benefit from that project where are the clinical trials being held in what state is there a protocol for testing.

    • I would kick your teeth in

      What a chump, what impoverished country did your unknown mom shot you out of her Anus? Hope your family dies in a fire you are scammer scum

  • Michael Russell

    I have been medication resistant all my life. I suffer from severe MDD, PTSD, GAD, AGORAPHOBIA, medication treatment resistant, suicidal ideations, and substance abuse but in MAT and have maintained sobriety for 6 years. I would 100% willing to attend medical trails and Williston travel. I don’t have a job nor can I maintain one due to my mental health. So I am available at any moment and for as long as needed. Please if you’re interested as I am please contact me at my email below and from there I can provide you with all the information and medical records needed. I will give you my personal number. Thank you and I pray that you consider me. My life is in a bad place right now as are family, children and personal relationship are very rocky. I look forward to hearing from you

    • Michelle

      Is it wrong to feel like you’re not enough or feel like you’re a burden to everyone you love ?

  • Clark

    Bulls***. I’ve been living with anxiety,panic attacks, seizures & depression for 17 years. Does it help with people suicidal thoughts?

  • Emily

    Can we give this to our politicians to see if that’s what’s gone wrong with our country?

  • Carol

    Yes, I’d also like to know the qualifications needed to be part of on-going study. Please provide.

  • Aaron

    ID definitely volunteer

    • Bob Marley

      You just want to get high. I’m afraid I must disqualify you from the trials. Perhaps sniff some glue or try some ganja

  • Deborah Jensen

    Hi, I have dealt with depression all my life. I would be interested in the final also.

  • Shay

    Very interested

  • George Rodriguez

    I’ll volunteer!

    • Manager in charge of stupids

      Denied. Too enthusiastic. Go snort some baby powder and pretend your high

      • Billy Bob Joe

        Ah ah ah! Yro’ue

  • Julie A McDonald

    I agree. I would love to be part of this research. So many suffer (myself and family included) more studies can only help. God speed!

  • Tim

    How long before it hits the market?

  • Patty Shaver

    Would like to know how this works on brain injury. And will there be trials that can be participated in?

  • Ryan

    The compounds in lions mane mushrooms are better at this than something made in a lab.

    • Burrito Supreme

      We do not recomend people eat lions, thanks for your interest but you are forever banished from the internet. Goodbye

  • Heidi

    So what does this mean for drug addiction?

  • Kristen Hall

    Sounds so promising. How and what do you need to be part of a study?

    • Chocolate starfish

      All you need is a butthole. Drug is given rectal boofed. Please email yourself for directions and wait for reply

  • Brady Wolfe

    Willing to be a human trial

    • Sizzle cut you down so low

      I get the impression you already are

  • K. Ferry

    Amazing! I’ve been on more s*** than you could ever imagine throughout my 34 yr long struggle w/bipolar & depression. Throw me in w the rats n mice! Please!

    • Boner T Squab esq

      Ok Ferry, your in! I like your style, no questions just enthusiasm! Someone will contact you through your dreams soon

  • Sarah

    I wish that some day we could get relief from these terrible illnesses.

    • Ernest goes to camp

      Yes it’s called death and she brings relief to all that suffer.

  • Dedra S Snowden

    I’ll be at clinical trial person I have been depressed all my life I have debilitating anxiety and this crap is just made everybody nervous as heck please let me in the trial let me in

  • Mary jane

    Like to try product

  • Rebecca Dàvis

    Would this be effective for those who suffer brain injury, permanent psychosis?

  • Rebecca Dàvis

    Brought on by Meth use…

  • Carole Ann Kelderman

    I too thought of trials. There is a website that lists all the clinical trials in the US, not sure about others. Think the site is something simple like Clincal Trials.org.

  • Pinky Car

    Official Lab Guy above is hardly official lol

  • Tina Murray

    This is fantastic news! Sounds like we are well in our way to that 1st person cured from Alzheimer’s and Dementia. Way to go! Keep up the good work and God speed!

    • Classy Lady

      Nothing like a bit of false enthusiasm to spice up a hot plate of excrement

  • Minnie

    I’m tired of depression pills

    • Too easy peazy pie

      Perhaps you don’t realize your already cured

    • Research Team Manager

      Serious Candidates can Participate, there are enough space for all, (530) 454-7101 Get in touch with the Team Manager and receive the full details and information.

  • ROBBIN Orr

    How can one go about getting in to the test group?

  • Linda Eidsness

    My son is Asperger’s he’s 20 years old and gone through so many medications and fights taking his medicine. He’s called the ambulance and almost went to jail ohis meltdowns

  • Ed

    Are they still looking for participants? I’m interested.

    • Can't hurt

      Just smoke some of that Mary Jane

  • Erica

    I can’t believe that people are willing to participate in a clinical trial of this magnitude. This is just an assumption that this pharma company is willing to test out since mice aren’t anxious or stressed out anymore… Lol.

    • Sad but I know

      Hardly even that

  • Joy

    Can this drug be used by someone with and being treated for metastatic breast cancer?
    I’d love to try it for my depression and anxiety.

    • SPax

      How can I be part of the trial. Living in Australia

  • Khristina Roberts-Riches

    I tried emailing to see about becoming apart of the study and it said undeliverable. Please contact me if your still looking for participates.

    • Supervisor of names

      Sorry you have been rejected due to your weird name. Maybe next time

  • Paul

    There’s several drugs that already do this, but Big Pharmacy can’t make money off it so they are “illegal”.

    • Jeff Epstein is alive

      Wow you cracked the code. Our people will be at your door very soon to take measures you never reveal our secret. You should of kept your mouth closed about our sinister plan..

  • Scam Alert

    DO NOT RESPOND to the email from “Laboratory Director”. It is a scammer clearly being predatory to people in need.
    If you read through each of their “responses” none of them make sense, nor are full sentences. Please do not fall into this ill constructed trap.

    • Labrador Retriever

      You are obviously a scammer! I am the real Labadoodle director and you are shameless

  • Jacquie Heath

    My daughter would be a perfect candidate as with prior participation in studies she is truthful about effects but as to date nothing has corrected the problem in long term…and she deserves her life back

    • Billy Bob Joe

      This is a perfect example of being a s****y and horrible parent in general. No sane person would volunteer their own children to consume what would probably be deemed as dandruff flakes and salty drywall

  • Scam Alert

    The individual either offering the drug or suggesting the test group is a scammer. Do not provide them your information and notice their bogus email address.

  • Donna Lynn Artis

    Could this possibly help other Neurological diseases such as CRPS or Fibromyalgia??? I deal with CRPS and treatments are limited.

  • Dottie

    What is the name of the drug? I’m trying something similiar to what is mentioned here. It’s new this yr February 2022. I don’t believe it’s for me. It didnt agree with me. Got very sick.
    Just wondering if it the same Drug

    • Hand of god

      Hi Ella. I contacted you yesterday and your mother is a whore. I hope you get tounge cancer and your loved ones die a painful death

  • Jens Charles

    Perhaps this will give me back my life it’s such a waste right now..I feel so stupid and worthless

    • God

      You are correct. There is no hope for you. Don’t even try cause you wouldn’t known where to begin. One day you will be gone and No one will ever know you were Herr. Seriously, you are weak and pathetic so as you were.. Hardly worth a response you worm, curse you and all you touch, you are disease and nobody is coming to save you or even wants to, you deserve your life, garbage human waste of space, glad to see you go only hope it’s soon

  • William C Haynes

    I”m very interested in your trials!

    • Monkey nuts

      How dare you! Are you some sorta pervert?!

  • Michelle Merkley

    Will this drug be an option for people like me who suffer from MS related cognitive dysfunction?

    • Steal the Stop

      If your MS stands for “Monkey Scotum” then yes, it most certainly will be.

  • Alli Ross

    I have 3 of the 4 and would like information to become part of the trial.

    • Smarter than you

      How about you trial harder and get off the internet you worm

  • Gary

    Could this drug someday help my wife’s Thalamic pain syndrome? She is experiencing a tremendous amount of pain on her right side caused by a bleed in her thalamus.

  • DANNY

    Silly scientists… chew some gum with mannitol in it to address the blood brain barrier issue

    • Piss mouth

      You tell em Danny!

    • Dr. Fill

      People want thongs easy a d given to them. Don’t work like that dumb named lady. Here’s some free advice for your broke ass, take a chance. Moron

  • Penny Taber

    But… will it possibly be affordable to everyone??or just a pipe dream ?

  • Mivhelle

    I didn’t know that there are others that has been depressed for so long ….why did I feel like I was the only one going through it. I didn’t want to share my thoughts and feelings because my partner says im so negative who would want to be around me…but really I’m not all negative I just get depressed from time to time and have suicidal thoughts but don’t act on it …yet but there’s been close calls but I have a 6 year old to raise so I try my best to keep my head up ….isn’t there a group therapy that doesn’t cost that we can go to help us ?

    • 3rd world fake

      Dumb name. At least I am cool and funny. You are dumb boring tool trying to trick people. I bet you are stinky person, nasty teeth..

  • Joe

    Is that Hunter Biden holding the pill?

    • Trump is gay

      Good one

  • Andrea

    My husband would be a great candidate for trials, he has ptsd, anxiety through the roof, depression. He is 46 yrs old had a motorcycle accident with brain injury and now we live through hell most days because of the ptsd. Please help.

  • Brooks Prater

    I have depression, anxiety, poor memory and possible minor brain trauma, I would love to be in the test group for this med, how can i?

  • Marie

    Great news !
    How soon would this drug be available to the public?

  • Julia Neufeld

    How could I sign up for testing in the trials?

    • Suckers amuck

      Just stick your right hand in a blender and turn it on puree. Hold it in as long as possible and whola, your in my friend!

  • Lee

    I suffer from Bipolar 1 disorder and PTSD but all my hospitalizations were during to massive depression and I experience mostly depression and anxiety in everything especially just going out. I’m always in doors not active at all. Can this drug help

    • Smart guy

      Check out Ketamine treatments not this hogwash buddy

  • Jeff Fleming

    Human trials are very far off if during our life times.

  • Terry

    Will it help with Schizophrenia

    • Paranoid Android

      What are you crazy? Of course it will..

  • Kevin

    I was in a Tramatic Brain Injury back in 2000, case in point would this drug help 22 years after the initial cause of the Brain Injury?

  • Ralph

    What happens if you snort it?

  • Ralph

    You suckers believe everyrhing you read lol

  • Long daddy from Cincinnati

    Makes your dick 12″ too

  • Anne

    How do you participate in the clinical trials? I’ve suffered from severe depression and anxiety all my life. My doctor said she had tried everything. I’m going to another doctor, but won’t this drug be awesome. Both my parents died from complications of Parkinson’s.

    • Hermès

      This is a scam bs sweetie. Ask you doctor about Ketamine treatment and don’t belive this bs

  • Brandy

    How do you enter be part of the clinical trial ?

    • Wise up dummy

      We will be in contact with you via the Astral plane.

  • Steven Nickerson

    I mirror Michael Russell (comment above) symptoms and diagnosis completely. I also would be very interested in being part of the trial. Please I need help and want to help advance medicine in this area. Thank you and I hope to hear from you.

  • I would kick your teeth in

    What a chump, what impoverished country did your unknown mom shot you out of her Anus? Hope your family dies in a fire you are scammer scum

    • Steven Nickerson

      You need to shut the f*** up and mind your own business. You are a disgrace.

      • Suzi Homemaker

        Watch your language Mr dick lickererson. I have already contacted the local authorities about your beastilatly and you foul mouthed children dirtying up my internet!

  • Steven Nickerson

    I’m my comment above I said I mirror Michael Russell above. And I do except for substance abuse and family issues. Also I do not have a diagnosis for MAT. I apologize for not noting this in my original comment.

    • Harry Reams

      Listen here Steve Dickerson! What you did to my dog was not the least bit funny! I am still trying to get the peanutbutter out of his fur.. I will never let you or recomend to anyone your dog sitter services

  • Valdar

    It’s called weed.

  • Big John

    Will this cure my 2″ penis? It is very tiny and I am suffering so please don’t laugh at me

  • Snappy Comedy

    How about these gas prices right??

  • Mental Mary

    No part of the Research review here mentions Human trials or even close, drug not named, etc. Why are you expecting direct contact from a News Reporter writing an article ?
    http://Www.clinicaltrials.org or .gov is all available Studies registered w information and contacts to be a Volunteer in reality if possible.
    Comments is for ideas or opinions on this study information review and the location to actually read the Research Results Report as this has NOTHING to do with the Researchers?
    Researchers are not here.
    Search your Diagnosis in an .edu web search to get science facts in details 1st hand. Find the address of the Institution mentioned in the Article and go to their website and find the Researchers name there to contact about Volunteering in a future study. NIH website you can use the Grant numbers listed here to see the Research and any advancement in Trials or read information about how trials advance to ppl once not dangerous.
    May the Graces of all Higher powers that exist be available to help all Mentally distressed and those that Love them.
    Gene Sight testing is not new and available to all free or low cost. It checks your personal genes, like the 1 this drug targets as an enzyme by the letters, against all Safe Available drugs information available and how your body may react to be best or worst drug options to use or combine. Drug actions expected once taken. Release too fast or need a higher dose factors by your very own information of body make up. Tolerance and side effects may be explained on why things have failed.
    Getting a Neuropsychiatrist to listen more than 16 seconds as Researched time they do is a NonDrug start.
    Say I not you talking to docs it’s all about what I need. Not what you keep ordering me.

    • Patient Zero

      Thank you Mary that’s what I was saying but this Steve Dickerson guy keeps stalking me everywhere I go. Never the less I thank you for taking the time tonpost some good advice to people who are searching for answers but not that Stever Dickerson chap, he is not a friendly person and I think he is posting some very negative comments

  • Mental Mary

    Laws on Prescribing drugs Off-line for Diagnosis not researched to be effective to treat should be a crime and require a Documented reason to be reviewed by a Pharmaceutical educated doctor. Established Treatment guidelines are rarely provided or explained to desperate distressed patients in a volunerable position or even have symptoms Documented and then reviewed when you return to evaluate effective. Very minimal Professional behaviors in Clinical practices even when Training new Residents to be quality care.
    Amazing drugs by Science on how they target to work as stated here we have 1 approved, this is 3rd level of this drug target already being used that will be slightly different for those have same target just not able tolerate previous drugs. Addiction fears of doctors is as big as barriers to treatment being an OFF LINE DRUG.
    SHOULD BE An OFF DIAGNOSIS LABELED DRUG to First Do NO HARM and TBH with the ill person.

  • Dumber than dumb

    Never post your email fool. Hope you get lots of phishing scams idiot

  • James

    Yes please 🙋🏻

  • Jake

    Mine is 2” also Big John….from the ground.

    • No its really only 2"

      Yeah, mine too, that’s what I ment..

  • Trish

    My niece needs help…she did 1 line of cocaine laced with fentenol and is now screwed in the head..please help!!!! My sister is her caretaker. She has 2 children 9 and 14 and does not even think of them….she was a beautiful person who is Trapped in her own body. Her mom my sister 62yrs old now takes care of her …please help! Thank you

    • Snortzilla

      Can I get your plug? Email me I’m desperate

  • Raquel Rios

    Hello,

    I am interested on hearing more about this and how to be part of this. This could be life changing for many people including myself.

  • Stephanie

    I definitely would want to try this out in a trial. Since I have bpd and cptsd I’d like to see if it helps.

    • Gene Simmons

      It’s not a real thing sorry. Look deeper and don’t fall for hopeful wishes but seeks truth and facts

  • Daniel P Stephan

    I would love to be contacted to find out about this trial!

  • Scarecrow in oz

    If you call that number you deserve to be ripped off. Don’t be a schmuck!

  • Bryan Scott Dillard

    I am so interested in trying this medication and seeing if it’s what would help me.
    Will definitely try to find out more

    • Average bear

      Snake oil my man

  • Michael J Gonzales

    Sign me up

    • Buddy the boofer

      Done! Check your anus for directions on what to do next! Congrats!!

  • Stefanie E Monforte

    Sounds very promising. I’m from Birmingham and and living just north of 6 ow in Oneonta. I’ve been suffering from major depressive disorder for most of my life along with generalized anxiety disorder so trying to live with and treat those conditions has been challenging at best. This is the first of any truly new drug I’ve seen in quite some time and I’d welcome an opportunity to participate in any tests or Human trials for this drug. I don’t know where to go to find out more about it but I’ll find it. Thank you!
    -Stefanie

  • Ben Guthrie

    I wonder what happens if you take 2?

  • Monica Childers

    How/Where do I sign up?!

  • Martha/Casey-Lungren

    Tell me what is so different about
    this new drug of choice? Will it
    interfere with someone who is on a legal cocktail of prescriptions?
    Yeah- that depends, of course.
    On

  • Rhonda Garcia

    How does one get in to c if it works I have a timor in my spine that can’t b removed and is attached to my spinal canal I have to do radiation therapy to strink it I have depression a. D. D. D. Bi-polor nerve damage muscle damage sometimes feels like I have altimers I’m only 52 I I have anxiety really bad

    • Budda Buddy

      You prob should be depressed you are having hard times and that’s normal. I pray you are healed but things don’t work that way

  • Glenda

    How does one get into a test group?

  • Tonie Lopez

    I’m interested in joining the test group? What do I need to do

  • Kelsi

    No way there is no trust in any drugs because it’s will damage your system case and cause mental behavior!! Time for anyone wanna move countries living in please learn about your control taking YOGA MEDICINE WITHOUT ANY HARM YOURSELF!

    • Pranhansa bullshitski

      Sorry but you are dumb. Congratulations though you won! You can downward dog my nutsack

  • Ella Ward

    I want to thank you again for the opportunity you gave me and the hard work you put into your research career to ameliorate people’s lives around the world, I received the New Drugs last 3 days ago and I am observing many positive changes in my life every single hour, once again thank you Doctor.

  • Alice Mitchell

    So what is this great pill called

    • Your mom

      It’s called make belive. Sure your familiar with it

  • S. Leanna

    Hello. The time frame to patients is what I wonder about. If it can aide in depression how wonderful. So much promise but no reporting back to the public. MD’s tell patients nothing in the medication options. Frustrating.

  • Stephanie Thompson

    What are the requirements and steps to get into the trial group?

  • Tess

    Yeah, it’s called exercise and proper nutrition.

    • stompie

      For real

  • Silas Thomson

    Any chance we can sign up for a trial?

  • Joshua Hunt

    Have they begun trial using this drug on Huntingtons Disease?

  • Seriously Though!

    This makes absolutely no sense whatsoever. Why are you selling what you’re saying is a “new drug” that works to prevent brain tumors? The so-called article is about depression, anxiety and dementia.
    You need more help than the people you’re trying to Con into buying something that’s a bunch of nothing but profit for you and a loss of money and who knows what other damages to those taking your so-called cure.
    Remember people, it’s still called “The Practice of Medicine” and this guy wants to play with your body like a lab rat.
    Why does everyone want to think a pill will fix everything?
    Start with not poisoning yourself with what you eat and drink.
    Do your research on the air, water, land around you and how it’s affecting you and others lives. For one, you probably shouldn’t be drinking the tap water!
    That old saying about “You Are What You Eat” is more true than we ever thought!
    Heal yourself.

  • Marilyn Holm

    Our president Joe Biden needs this! He won’t even take a cognitive test, and everyone covers for him, would be great to see a miracle.

  • The holy one

    Whoever goes as the name ‘me, are you that pathetic and such a loser you have nothing better to do but remark people who have issues! Your sloppy errors, perhaps to much vaseline and not enough tissue.

  • Joe Biden

    How long until the pill is absorbed in my anus and the effects begin to kick in?

    • Steal the Stop

      Ur still doing that!? That’s so last year. It’s all about pecker boofing now. You want a rush, shove a gram of meth right in the ol dick mouth and then come leave a comment.

  • Shrek, The True Buddha

    This comment section will do more to temporarily alleviate depression than most medicines.

    • Tiny Hands Frump

      You are indeed the True Buddah and capable of such divine compassion. Perhaps I will write a book about you one day?

  • Nicole Franco

    Anyway I could please get into the test group for this as I severely suffer from anxiety and nothing has worked that my doctor has prescribed.

  • Joe

    Hunter? Put down the pills, Hunter! Do it for the Big Guy.

    • U r dum dum

      Hunter my nutsack numbnutts..

  • Debbie Cherbini

    I would love to get involved with this. It sounds just like me and my problems.

  • Becky Foster

    to cure or improve the lives of these illnessesis a gift .God be with those creating a cure.. These conditions are so hard on the patient and families. THANK YOU FOR THE DISCOVERY AND COMMITMENT TO FIND A CURE.

    • Jay low

      Please you trippin girl

  • Susan D Smith

    I have had a serious personality change in the last 5 yrs and I don’t know why. My symptoms prevent me from finding out what has happened to me. I went from being always on the go hardly ever sitting still always organized clean house active in the yard maintaining all bills to then doing anxious scrambled not being able to get a grip almost frozen overwhelmed no energy and missing myself . I feel like I’ve been kidnapped. I feel the guilt from not being me but can’t get it together. How can I try a study like this? Please help

    • Taoist Ninja

      This will not help. You are not alone yet you are, get it? Nobody is coming for you and no drug will cure your sickness. No God, no Jesus, You know :The Heros Journey”? Of course we all do. It begins with a calling, the way you feel is the calling. The rest is your art, your life, you.. Its not easy but there is no other option. GL

  • Amused

    This is hilarious content. Thank-you!

    • Mr. Buttersworth

      Thank you! Amused, that means alot. Glad I could put a smile on your face now tag, your it!

  • Margaret Brown

    This is great news! How many ‘studies’ dies a new drug have to go thru to get approved, for human consumption, by the FDA? The article did not mention whether or not if it was to prevent/help lessen a brain injury or if the drug help the brain regenerate parts damaged post injury. This would be an inquiry that I would like to know.last, how does one get included on the clinical trials. Is there somewhere that can answer all or any of my questions?

  • Louise Kathy

    Yes pleae! I could benefit from this tremendously!

  • Jan Vigil

    I would love to be in the test group! Please consider me & feel free to contact me with any and all questions you may have. What a wonderful thing you’re doing for the people across this country. As well as for the citizens around the globe.
    Thank You!
    Sincerely,
    Janice Vigil

  • H.M.

    Can this drug be used to treat people with epilepsy or people who suffer from the effects of prolonged seizures.

  • Jimmy

    Avxl trials under way in humans alzheimer parkinson rett and frontal lobe dementia….10 years ahead of this molecule..check it out. https://www.anavex.com/

  • Angel Bahena

    How can I be part of the trials?

  • Randi Gentile

    This sounds so promising. I would like to be involved. Are there any studies on humans yet? I’m very interested.

  • Ed

    How do I get on the trial I have parkinson’s

  • Teresa. L Poulson

    As far as I know the test was a year ago. I was asked to be in a trials then. A Dr from unmc contact me on the study for a drug that they disturbed. But due to a family illness I couldn’t do it. But if it works I will take it. I have all the stuff that they say it will fix. Have a wonderful day. Love you 🦋

  • Donna Robinson

    I would love for my son to be a part for brain injury

  • Kristen Singo

    I’d love to be tested! I have all of the above, and am on too many medicines. This would be a life saver for sure!

  • Genevieve Morris

    What is the name of this new medication??

  • Lynnett Villa

    I have been waiting for this day for so long.My son and I both suffer from TBI and my mother passed from Alzhimers. My son has has schizophrenia, bi-polar, severely manic. Doctors don’t have answers , they just keep throwing meds at him , which have made him worse . Lately he has been very suicidal and I fear for him. I just want to see him gave a beautiful life and be able to be a father to his children .

  • BigPharma AtItAgain

    The prolific emoji use like that of sixth grader gives me the heebee geebees.

  • Derrick

    Ph…ut

  • Rita C Herrin

    I suffer from a traumatic brain injury I really want to know more and how does one sign up?

  • Just for u babe

    Wow the smart ass on here is entertaining. He, like his dog loves peanut butter. It’s the only grip his shot out Anus has left. But he makes for a great cumdump

  • Chemical brother

    This comment section has me dead. Thanks random troll commentor. I love you

  • Brandon Schmidt

    Please I would definitely like to be in trials I suffer from depression anxiety and extreme stress please reach out to me

  • Rosie

    Does this sorl for recovering addicts

  • Erin

    Don’t test animals, okay? Test it on prisoners instead.

  • Steal the Stop

    As a former prisoner and a current animal I find that offensive

  • Carl Werstein

    I would benefit from this

  • Heather

    Clinical trials?

  • Rick karosa

    I’ll try it

  • Billy Bob Joe

    This sounds like something Jeff bezos or elon musk would do just to get money out of the bottom 90% of the collapsing society that is known as the United States. It literally hurts to watch what was built with good intentions at heart, be defiled perpetually via s****y predicaments and people just being overall in a state of pure intellectual failure.

  • Katherine Gallagher

    My husband (80 years old) has been suffering from medication resistant depression for over 20 years. He has tried almost every drug available as well as TMS and ECT with little to no improvement.

    Any chance that he could join the study?

  • Optimistic

    Would it help all the pessimistic people on this post

  • Theodore Reed

    I would love to volunteer to take this drug especially knowing as a veteran. It will help us after all of the things we’ve lived through
    Yes sign me up

  • Donald Trump

    Can I get this pill? The election was stolen from me! I’m so depressed!

  • Stephen Hockaday

    how do I contact Dr Gibbs in reference to participating in the clinical trials to receive CDK-5

  • David L Marshall

    Is that Hunter Biden holding the pill?

  • Majid Naghdi photographer

    Hi: Tahoe Hadd can be trusted with this drug. And does it have consequences after taking. And when will it be available to those in need

  • Shaun

    Will this help epilepsy?

  • Mark Lanfear

    F*** Pharmaceuticals. The planet has everything we need. A marijuana plant provides 90%of what these pharm pills might do, OH WHAT ARE THE SIDE EFFECT OF SAID CHEMICAL SNAKE OIL ????

  • Mike

    Prescribe it universally and watch all liberalism disappear.

  • Pharmonsudacle Technique Tryit Assoc

    Well, it isn’t surprising the miracle of a new drug, however the future skin soothing and toenail fungus leads to amputated fingers but strangely you keep both thumbs up or down perhaps even left or right. Furthermore, any whining and mention of lawsuit results with government housing and slaving away at life without perks for sure

  • Gabriel Bruno

    For those i guess that want the pill almost as if they think the pill will bring them back to reality is this is who i am and only thing I don’t want to be is like everyone else tired of being there lab rat.

  • Brainsparks123

    Attention people of Earth!
    We run your pharmaceutical companies, and we enjoy watching all of you run around like your lab rats in a cage. Soon, after the drugs have had time to alter your DNA about ten years from now, we’ll be landing as an invasion force, and plan on eating you all…

  • Adda Boy

    Two words that changed my life after having to leave my law enforcement career on a team in a special unit to a bumm making 2500 a month on disability. PTSD the govt. SS office dr said. ADEROL AND TESTOSTERONE!!! Went from bedroom to couch/tv for years, first day i took it, after a year of trex deck material sitting, replaced thay deck by 9am,would have retired at 42 so alot of free time and prescribed quadruple the legal limit but i get em filled, so now 5k cash a month, free oil and food assistance,food card with 1100$ on it with covid bonuses, 75% off electrical, but i went from 50 steps a day to miles and remodeled home, do side jobs which isnt part of the 5k i make,no depression, energy, annd body better than when i was 20,,mid forties today. Test is the fountain of youth in ALL areas and i always have to be doing something.productive and was offered a 12 month 38k trial by phizer which is close in CT, but no guinea pig here. im loccked in on my Addys but its sought after more than coke, new white man’s 1.20 copay for one script of 90 thirty mgs z month, second is more, . movement stops depression and anxiety, which ya cant do when your going thru it, pop an orange or 3, and i stock option day trade making a ton bettinng on stocks to go down for 3 years now pulling all nighters studying, LIMITLESS, the movie is all I gotta say, with a strong libido and muscle help. Lol

  • Giovanni Montero

    Please contact me for test.

  • Norma

    Please tell me how I might be a participant in
    This program. Please.

  • Laura Carr

    Don’t really wanna be a ginny pig but I’m losing hope at this point I’m willing to try anything. I’m finding myself more and more worthless I have no good support witch may be most of the reason ..I seen I can’t find myself again so if this magical pill can take way the hurt the emptyness the struggles I have with moving on ..well I’m down if it for 5 min it makes me feel worthy of the the devil’s curse on good people cause that who suffer from these are people who care I miss the feeling of loving life and my self .so by all means I’m in

  • Mona

    How do you get into a clinical tril?

  • Laurie Eakes

    I would like for my husband to be considered for the clinical trials.., if and when possible

  • Elissa Martinez

    Well this medication help a brain injury that occurred at birth. What I’m asking is: Will this medication help with hypoxic ischemic encephalopathy??? Will it be able help Epilepsy and get back Vision, Speech and Mobility..

  • Lindsey groves

    I have brain injury and depression. So u would like infomation on these study groups.

  • James whittemire

    I would try this has test subject because I need all the help I can get please.i asking for help .

    • Jah Hova 🙌

      I still think oxycotin is the cure all pill. I took 320 mg a day for 4 years and never once was depressed, had great energy and whatever dream I dreamed up was alive. Hit me up when a similar drug needs clinical rats!

  • Kyla

    I have anxiety and conjunctive issues could this help me

  • Danielle

    I’m interested in knowing more about this medicine! I have severe social anxiety I can hardly go out in public! Also battle with olfactory reference syndrome. I don’t know which is worse the anxiety or olfactory reference syndrome. Also suffer with depression, but that’s the least of my worries!

  • Jay

    No body even asked about the side effects or how many animals died from it. Then wonder why they’re so much corruption and scam’s going on. People like you jumping head over heals over a dumb Post.

  • Michael Zazzaro

    I am interested in being in your clinical trials. Please let me know how to enroll.

  • KCPetite1

    We don’t need anymore poisons (magic pills that don’t work and harm people).