Inflammation is a vital biological response of the immune system to protect the body from infection and injury. It occurs when tissues are damaged by bacteria, trauma, toxins, heat, or any other cause. The damaged cells release chemicals including histamine, bradykinin, and prostaglandins, which cause blood vessels to leak fluid into the tissues, leading to the characteristic signs of inflammation: redness, heat, swelling, and pain. This response is intended to isolate and eliminate the injurious stimuli and begin the healing process. While acute inflammation is typically short-lived and beneficial, chronic inflammation can lead to a host of diseases, such as arthritis, heart disease, and various autoimmune disorders. Chronic inflammation is problematic as it signifies a prolonged immune response where inflammation becomes a persistent condition, potentially damaging healthy tissue and altering normal physiological processes.
New research indicates that inflammation in macrophages caused by lysosomal dysfunction contributes to severe symptoms in lysosomal storage diseases. Targeting specific pathways in these cells…
Researchers in Bonn have decoded the interaction between monocytes and platelets in human blood. Monocytes, a unique type of white blood cell, release cytokines as…
Nagoya University researchers found that deficiencies in gut bacteria genes for vitamins B2 and B7 are linked to Parkinson’s disease, suggesting that B vitamin supplementation…
Cambridge researchers have discovered that regulatory T cells traverse the body to repair tissue, opening avenues for targeted treatments in various diseases. Researchers at the…
Weill Cornell scientists discovered a crucial link between two immune pathways involving IL-23 and CTLA-4, impacting the understanding and treatment of inflammatory bowel diseases and…
Research reveals that low-dose aspirin reduces inflammation caused by lack of sleep. New research has found that low doses of acetylsalicylic acid, commonly known as…
Harvard researchers have found that the maternal immune response to viral infections in pregnant mice can be detected by microglia in the embryo’s brain, altering…
Researchers show that the possible cause of local bone erosion in cholesteatomas are fibroblasts from the bone that express a protein called activin A. Chronic…
Research reveals that treating depression and heart disease together could reduce the risk of heart muscle disease. Coronary artery disease and major depression may be…
Scientists at Scripps Research have developed atomic-level structural models of enzymes linked to autoimmune and inflammatory conditions, such as lupus and Alzheimer’s disease. When nucleic…
Inhibiting the STING protein in aged mice leads to decreased inflammation and improved memory and physical function, highlighting a promising approach to mitigating aging-related challenges….
A review of 700 studies indicates that incorporating ginseng into one’s diet as a supplement may aid in physical recovery post-exercise, improve performance, and reduce…
Scientists at Cambridge may have uncovered a novel mechanism by which fasting can reduce inflammation – a potentially harmful consequence of the immune system’s activity…
Salk scientists outline mouse cell inflammation pathway from mitochondrial stress to leaking endosomes to immune system initiation, revealing new potential therapeutic targets to reduce inflammation…
Researchers presenting at the annual meeting of the Radiological Society of North America (RSNA) have discovered objective evidence showing the involvement of neck muscles in…
A Harvard study demonstrates that perceived time can accelerate or slow down physical healing, suggesting a strong mind-body connection in health. Perceived time has a…
AG5 inhibits the cytokine storm similarly to corticosteroids, but unlike them, it adequately preserves innate immunity. Early in the COVID-19 pandemic, clinical trials with hospitalized…
UNC researchers have discovered how cancer cells escape immune detection by deactivating the cGAS-STING pathway, offering new avenues for cancer treatment. Every time a cancer…