Double Your Odds of Quitting Smoking With Cytisine – If You Can Find It!

Woman Quit Smoking Cigarettes Concept

A study in Addiction shows that cytisine, a cost-effective smoking cessation aid from Eastern Europe, significantly increases quit rates compared to a placebo and might be more effective than nicotine replacement therapy. Safe and used since the 1960s, its availability is limited to certain countries, impacting its potential global health benefits, especially in low- and middle-income nations.

Cytisine, a generic smoking cessation aid, has been shown to double the success rate of quitting smoking compared to a placebo. Despite its safety and effectiveness, it remains largely inaccessible outside Eastern Europe, limiting its global health impact.

A new study published in Addiction has found that cytisine, a low-cost, generic stop-smoking aid that has been used in Eastern Europe since the 1960s, increases the chances of successful smoking cessation by more than two-fold compared with placebo and may be more effective than nicotine replacement therapy. It has a benign safety profile, with no evidence of serious safety concerns. Sounds perfect for your New Year’s resolution, doesn’t it? But there’s a catch: Cytisine is not licensed or marketed in most countries outside of central and eastern Europe, making it unavailable in most of the world, including many low- and middle-income countries where it could make a big difference to global health.

Cytisine’s History and Current Usage

Cytisine is a plant-based compound that eases smoking withdrawal symptoms. It was first synthesized in Bulgaria in 1964 as Tabex® and later spread to other countries in Eastern Europe and Asia, where it is still marketed. In 2017, the Polish pharmaceutical company Aflofarm began selling it as Desmoxan®, a prescription-only medicine, and Canada approved it as an over-the-counter natural health product, Cravv®.

Because cytisine is a low-cost drug, it could form part of a plan to increase accessibility to drug therapy for smokers, which tends to be limited in low- and middle-income (LAMI) countries.

Study Findings and Global Implications

Lead author Dr. Omar De Santi elaborates: “Our study adds to the evidence that cytisine is an effective and inexpensive stop-smoking aid. It could be very useful in reducing smoking in LAMI countries where cost-effective smoking cessation drugs are urgently needed. Worldwide, smoking is considered the main cause of preventable death. Cytisine has the potential to be one of the big answers to that problem.”

This study pooled the results of eight randomized controlled trials comparing cytisine with placebo, with nearly 6,000 patients. The combined results showed that cytisine increases the chances of successful smoking cessation by more than twofold compared with placebo.

The study also looked at two randomized controlled trials comparing cytisine with nicotine replacement therapy, with modest results in favor of cytisine, and three trials comparing cytisine with varenicline, without a clear benefit for cytisine.

Reference: “Evaluation of the effectiveness of cytisine for the treatment of smoking cessation: A systematic review and meta-analysis” by Omar De Santi, Marcelo Orellana, Cecilia Andrea Di Niro and Vanina Greco, 31 December 2023, Addiction.
DOI: 10.1111/add.16399

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