Activities could be modifiable risk factors for the disease.
A study from Michigan Medicine suggests that participating in recreational activities — including golfing, gardening or yard work, woodworking, and hunting — may be associated with an increase in a person’s risk for developing amyotrophic lateral sclerosis, or ALS.
While many activities were associated with increased ALS risk, several were sex-specific. The results are published in the Journal of the Neurological Sciences.
“We know that occupational risk factors, like working in manufacturing and trade industries, are linked to an increased risk for ALS, and this adds to a growing literature that recreational activities may also represent important and possibly modifiable risk factors for this disease,” said first author Stephen Goutman, M.D., M.S., director of the Pranger ALS Clinic and associate director of the ALS Center of Excellence at the University of Michigan.
“Future studies should include these activities to pinpoint how they can be understood in the context of ALS prevention, diagnosis, and treatment.”
Study Findings and Gender-Specific Risks
Investigators surveyed 400 people living with ALS and nearly 300 without the condition to assess their hobbies and non-work related activities.
They found that golf was associated with a three times greater risk of developing ALS among men. Participation in gardening or yard work, as well as woodworking and hunting, was also linked with a heightened risk for men.
When broken down by sex, no recreational activities had significant associations with ALS for females. None of the hobbies were linked to earlier onset of, or death from, ALS for either sex.
“It is surprising that the risk factors we identified appear to be specific to males,” Goutman said.
“While these activities may also increase ALS risk in females, the number of females in our study was too small for us to come to that conclusion.”
Environmental Factors and ALS Risk
The findings join the growing body of evidence suggesting that environmental exposures affect a person’s risk for getting and dying from amyotrophic lateral sclerosis. Researchers call this lifetime accumulation of exposures the ALS exposome.
Hobbies such as golfing and gardening or yardwork, Goutman says, may confer risk due to the use of pesticides. A past study connected occupations in golf and garden maintenance to increased ALS risk.
Extensive studies of woodworking lead researchers to believe that formaldehyde exposure during the hobby could be attributed to higher risk.
“Our goal is to understand what occupations and hobbies increase ALS risk because identifying these activities provides the first step towards ALS prevention,” said senior author Eva Feldman, M.D., Ph.D., director of the ALS Center of Excellence at U-M and James W. Albers Distinguished University Professor at U-M.
“For a disease like Alzheimer’s, we know that a list of factors — including smoking, obesity, and high lipids — can increase risk by 40%. Our goal is to establish a similar list for ALS to create a roadmap to decrease risk. With apologies to Robert Frost, it is currently the ‘road not taken’, and we want to change that.”
Prospective studies are underway to examine individuals who work in production, manufacturing, and jobs that involve the use of metals, and for persons with a family history of ALS.
Both Goutman and Feldman say it is too early for clinicians to advise that patients stop doing any of these activities.
Reference: “Avocational exposure associations with ALS risk, survival, and phenotype: A Michigan-based case-control study” by Stephen A. Goutman, Jonathan Boss, Dae Gyu Jang, Caroline Piecuch, Hasan Farid, Madeleine Batra, Bhramar Mukherjee, Eva L. Feldman and Stuart A. Batterman, 23 January 2024, Journal of the Neurological Sciences.
DOI: 10.1016/j.jns.2024.122899
Funding: National Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences, National Institute of Neurological Disorders and Stroke, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention, ALS Association, NeuroNetwork for Emerging Therapies, Robert and Katherine Jacobs Environmental Health Initiative, NeuroNetwork Therapeutic Discovery Fund, Peter R. Clark Fund for ALS Research, Sinai Medical Staff Foundation, Scott L. Pranger, National Center for Advancing Translational Sciences (NCATS)
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