The new finding could pave the way for new effective treatments for the coronavirus.
They discovered that the organic compound can bind to many SARS-CoV-2 proteins.
Researchers have discovered that salen can effectively bind a number of proteins of the coronavirus SARS-CoV-2. CoV-2’s Scientists utilized molecular docking to reveal that salen binds to the non-structural protein nsp14, which prevents the virus from being destroyed. The discovery may aid in the development of novel drugs and coronavirus infection treatments. The study’s findings were recently published in the journal Polycyclic Aromatic Compounds.
“Our study focused on a well-known compound, salen. We tried to assess the potential activity of this compound against a series of proteins of the SARS-CoV-2, which cause the COVID-19 disease. We found out that salen can potentially interact with the studied proteins, and the best results were obtained for the non-structural protein nsp14, which protects the virus from destruction,” says Damir Safin, Research Engineer at the Organic Synthesis Laboratory of Ural Federal University.
According to scientists, salen – the substance in the photo – is relatively simple and inexpensive to synthesize. Credit: Ural Federal University / Damir Safin
The term “salen” refers to a tetradentate Schiff base derived from salicylaldehyde and ethylenediamine. Salen and its derivatives are key ligands in a wide range of practical applications. This is an organic substance that has the ability to coordinate certain metals and keep them stable in various oxidation states. Metal complex compounds of salen derivatives are also used as catalysts.
Two “fluid” hydrogen atoms of hydroxyl groups are found in salen. Each of these hydrogen atoms has the ability to move to a nitrogen atom, therefore changing the shape of the molecule. This process is known as tautomerization, and the participants are tautomers or tautomeric forms.
“We’ve explored the potential interaction of various tautomers salen with SARS-CoV-2 proteins to identify the most preferred tautomeric form of the studied molecule in terms of the effectiveness in interaction with proteins. Of course, our research is only the first step towards understanding how salen can be used in the fight against COVID-19, much remains to be explored. However, the results we obtained inspire a certain optimism,” adds Damir Safin.
Reference: “Salen: Insight into the Crystal Structure, Hirshfeld Surface Analysis, Optical Properties, DFT, and Molecular Docking Studies” by Maria G. Babashkina, Elizaveta V. Panova, Larisa E. Alkhimova and Damir A. Safin, 22 July 2022, Polycyclic Aromatic Compounds.
DOI: 10.1080/10406638.2022.2097281
A study was carried out by scientists from the Innovation Center of Chemical and Pharmaceutical Technologies of Ural Federal University, Kurgan State University, and Tyumen State University.
All the coronaviruses and all their variants have different protein spikes, with Delta and Omicron having spikes that are more efficient at getting around the vaccines. But the real problem is in the virus itself, not its protein shell, and why the most dangerous (MERS, SARS, and Covid-19) are so infectious. My independent research has found multiple one-in-a-million nucleotide sequence matches between all the coronaviruses and the human genome. Those sequences are the same as some of the loops of human tRNA. Using those loops and their amino acid code matches, viruses may be able to fool the nucleus membrane in cells to allow the virus to enter and associate with the human DNA, creating more opportunities for further infection. Our immune system may be compromised and may no longer be able to stop the virus and other diseases from attacking organs throughout the body. Vaccines that attack the virus protein shells while ignoring their contents will always let some of the virus into our cells from the Darwin effect, but recognizing these loops suggests a possible approach to completely successful coronavirus vaccines. Only the infection process is considered in my work, not the innate virulence of the virus. Specifics on this can be found by searching YouTube for “Coronavirus – Using Your DNA Against You”
30 years never had a virus or bacteria infection = never ill: Mix one heaped teaspoon of salt in a mug of clean warm water – cup a hand and in stages, sniff or snort the mugful up your nose spitting out anything which comes down into your mouth. If burning sensation, you have a virus and the salt solution is disinfecting it, so wait 2-3 minutes until burning sensation goes away, then blow out your nose on toilet paper and flush away, washing your hands afterwards. Do my free salt water cure morning, noon, night or more often if you want, until it feels like you are flushing with water only – job done. 3 minutes idea to job done – simple. No virus, no Covid or Long Covid in your head possible. You cannot catch Covid, you have to catch a Coronavirus first and let it become Covid in the nasal passages of your head, later transported down into your body in the one liter of snot, or mucus, we each produce daily – the engine oil of the body. Vaccines – what for – I never have any. My method is like using a fire hose to put out a fire. It takes 3 minutes to prepare and do with salt and clean water and over the 30 years I and others have been doing it, it has NOT killed or injured ONE PERSON, unlike those synthetic mRNA vaccines, ALSO verified by Alberta Medical University – Canada. Do it – you will be amazed at how quickly it destroys colds and flu in the nasal passages of your head. No infection, no Covid possible. Spread the word to everyone please. Neti pots are like using a garden sprinkler to put out a house fire. your life, your choice!! AND free!!
Murder One: There were no COVID-19 vaccines close to approval on August 27, 2020. In fact, the Pfizer/BioNTech vaccine trial phase 2/3 had only started a month earlier on July 27.
The Initial Contract with General Dynamics
The first contract, with General Dynamics, is dated August 27, 2020. It outlines a series of services the company was to provide to the CDC pursuant to the “anticipated increase” in VAERS reports due to the COVID-19 vaccines.
There is no clause in the contract giving the CDC an option to cancel or suspend the contract in the event that vaccines would not be authorized. Also, the contract stipulates that the contractor would have everything up and running within 60 days of the contract, which means by the end of October. But what if the vaccines were never approved? Or what if they were approved much later, say in February, April or June? Was the CDC just going to hand over [redacted] millions of dollars to the contractor for nothing? Or did the CDC know something about the impending approval of COVID-19 vaccines? It certainly appears that by August, 2020, the impending emergency use authorization of at least one COVID-19 vaccine was a foregone conclusion.
BioNTech CEO Ugur Sahin says that his mRNA vaccines rolled out in January this year (2021): Link here: https://www.ibtimes.sg/fact-check-biontech-ceo-ugur-sahin-refuses-take-pfizer-covid-19-vaccine-due-safety-concerns-61652 but by August 27, 2020 – The first contract, with General Dynamics, is dated August 27, 2020 had been let and the contract states that they were expecting up to 1,000 VAERS reports to be filed per day, with up to 40% of the reports being serious in nature and the CDC was already anticipating that the COVID vaccines might generate nearly seven times as many reports as all other vaccines combined (a 600% increase), with a rate of serious adverse events that could be up to 8 times higher, (bearing in mind that VAERS represents only 1% of all injuries and deaths recorded and multiplying the numbers given by 41 (x41) gives a much better appreciation of just how many American’s were being injured or had died, after vaccinations began in early 2021), on a daily basis: see below
CDC Expected Huge Increase in VAERS Reporting
The contract states that they were expecting up to 1,000 VAERS reports to be filed per day, with up to 40% of the reports being serious in nature:
According to the contract, VAERS had been receiving an annual average of 53,000 reports in recent years, so in contracting for up to 1,000 reports per day, the CDC was already anticipating that the COVID vaccines might generate nearly seven times as many reports as all other vaccines combined (a 600% increase), with a rate of serious adverse events that could be up to 8 times higher.
The initial total amount specified (with options) under the contract with Eagle Health Analytics was $5,925,388.58 or $7,077,054.90 “with all options” (which presumably includes the extension of the VAERS work through July). This amount also includes the CISA project assistance. However, it does not include the increased hours in the Oct. 29 revision, nor the increase for the V-SAFE pregnancy registry work. However, I have not been able to find the contract in any Federal contracts database. Perhaps one of my readers will have better luck.
How Much Did All of This Cost?
The amounts paid out under the contracts with General Dynamics were redacted. But according to this site, the initial amount paid was $9.45 million, with $4.4 million added in late February, and then an additional $16.3 million tacked on in early March. In March of 2022 there was an additional $5.2 million added, though it’s not clear for what since the contract had presumably expired by then. (Best guess is that General Dynamics continued some or all of its work on COVID VAERS reports with Eagle Health brought in for additional support.) Grand total? $35,425,642 of your taxpayer dollars.
So the next time somebody says that VAERS data is worthless, ask them why the Federal government paid contractors at least $45 million dollars over 2 years to maintain this “nationally critical function.”
The Contracts
23 00099 General Dynamics Information Te…
https://substack.com/redirect/dac78dc8-9d2d-4280-a390-218d47bb331d?j=eyJ1IjoibjFlaXcifQ.OkComRnvTz45cW2ospKdwvhGbhkMepFwvepUF91fYF0
23 00099 Eagle Health Analytics, Ll
https://substack.com/redirect/bcba05ff-1dce-4b15-a6a7-0f59f3cb115a?j=eyJ1IjoibjFlaXcifQ.OkComRnvTz45cW2ospKdwvhGbhkMepFwvepUF91fYF0
An anonymous source has sent me (Josh Guetzkow) two key contracts obtained via FOIA between the CDC and two contractors hired to assist with COVID-19 vaccine safety monitoring, including reports to the Vaccine Adverse Events Reporting System (VAERS). “Assist” is not quite the right word, since the contracts essentially outsource VAERS maintenance and reporting for COVID-19 vaccines to these companies. Both contracts are embedded above, of this post.
The above information posted by Josh Guetzkow – which I happened to come across.