Immune Response to Heart Attack Can Worsen Atherosclerosis

Heart attack worsens atherosclerosis

Harvard University Professor of Cardiac Surgery R. Morton “Chip” Bolman inside OR6 at the Brigham and Women’s Hospital performing open heart surgery for a patient with a history of aortic insufficiency and an ascending aortic aneurysm. Credit: Staff Photo Justin Ide/Harvard News Office

A new study explains possible reasons why heart attack patients are at an increased risk for a second heart attack or a stroke, finding that the immune response to the infarct can accelerate the underlying disease by actually increasing the size and inflammation of the atherosclerotic plaque.

A heart attack doesn’t just damage heart muscle tissue by cutting off its blood supply, it also sets off an inflammatory cascade that worsens underlying atherosclerosis, actively increasing the risk for a future heart attack. These findings from a study receiving advance online publication in the journal Nature suggest an important new therapeutic strategy for preventing heart attacks and strokes, both of which are caused when atherosclerotic plaques rupture and block important blood vessels.

“We have known for a long time that heart attack patients are at increased risk for a second heart attack or a stroke, and now we know why,” says Matthias Nahrendorf of the Center for Systems Biology at Harvard-affiliated Massachusetts General Hospital (MGH). Nahrendorf, assistant professor of radiology at Harvard Medical School (HMS), is the senior author of the report from a team of researchers from the United States, Canada, Germany, and the Netherlands. “The immune response to the infarct — tissue damaged by lack of oxygen — can accelerate the underlying disease by actually increasing the size and inflammation of the atherosclerotic plaque.”

The study was designed to test the hypothesis that systemic inflammation caused by heart muscle damage would worsen pre-existing atherosclerosis. Using a mouse model genetically programmed to develop atherosclerosis, the researchers conducted a series of experiments showing that experimentally induced heart attacks led to the following:

  • Increased activity of enzymes that break down the fibrous plaque cap in atherosclerotic plaques at a distance from the induced heart attack, possibly leading to future rupture;
  • Accumulation of monocytes and other inflammatory immune cells in those atherosclerotic plaques;
  • Increased generation of monocyte progenitors in the spleen, along with changes in the function of those immune cells; and
  • Increased release of blood stem cells from the bone marrow, which traveled to the spleen, triggered by increased activation of the sympathetic nervous system.

“The ancient fight-or-flight responses to injury stimulate immune cell activities that are involved in wound healing. But when the ‘wound’ is in the heart and caused by atherosclerosis, that increased activity actually accelerates the underlying disease,” Nahrendorf explains. “While most of this work was done in mice, we have hints that something similar may happen in human patients — for example, we found increased numbers of blood stem cells in the spleens of patients who had died shortly after a heart attack.”

Ralph Weissleder, professor of systems biology and of radiology at HMS and director of the MGH Center for Systems Biology, adds that these findings set the stage for a totally novel approach to cardiovascular disease. Therapies directed to the sites of white blood cell production, including the bone marrow or the spleen, may be able to prevent immune-system exacerbation of atherosclerosis.

“This gives us potential new therapeutic targets that we had not thought about before. Clinically, we focus on reducing risk factors such as elevated cholesterol and blood pressure, but not inflammation. We hope our work can help change that,” Weissleder says.

Reference: “Myocardial infarction accelerates atherosclerosis” by Partha Dutta, Gabriel Courties, Ying Wei, Florian Leuschner, Rostic Gorbatov, Clinton S. Robbins, Yoshiko Iwamoto, Brian Thompson, Alicia L. Carlson, Timo Heidt, Maulik D. Majmudar, Felix Lasitschka, Martin Etzrodt, Peter Waterman, Michael T. Waring, Adam T. Chicoine, Anja M. van der Laan, Hans W. M. Niessen, Jan J. Piek, Barry B. Rubin, Jagdish Butany, James R. Stone, Hugo A. Katus, Sabina A. Murphy, David A. Morrow, Marc S. Sabatine, Claudio Vinegoni, Michael A. Moskowitz, Mikael J. Pittet, Peter Libby, Charles P. Lin, Filip K. Swirski, Ralph Weissleder and Matthias Nahrendorf, 27 June 2012, Nature.
DOI: 10.1038/nature11260

Co-lead authors of the Nature paper are Partha Dutta and Gabriel Courties of the MGH Center for Systems Biology. Collaborators include Filip Swirski of the Center for Systems Biology and Peter Libby, chief of cardiology at Harvard-affiliated Brigham and Women’s Hospital, where the clinical data were analyzed. The study was primarily supported by grants from the National Institutes of Health.

Source:Sue McGreevey, Massachusetts General Hospital; Harvard Gazette

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