New Antibiotic in Discovered in Tropical Forest – May Leaded to a “Plant Probiotic”

Tropical Forest

Findings may lead to ‘plant probiotic’ and new antibiotics.

Scientists from Rutgers University and around the world have discovered an antibiotic produced by a soil bacterium from a Mexican tropical forest that may help lead to a “plant probiotic,” more robust plants and other antibiotics.

Probiotics, which provide friendlier bacteria and health benefits for humans, can also be beneficial to plants, keeping them healthy and more robust. The new antibiotic, known as phazolicin, prevents harmful bacteria from getting into the root systems of bean plants, according to a Rutgers co-authored study published today (October 8, 2019) in the journal Nature Communications.

“We hope to show the bacterium can be used as a ‘plant probiotic’ because phazolicin will prevent other, potentially harmful bacteria from growing in the root system of agriculturally important plants,” said senior author Konstantin Severinov, a principal investigator at the Waksman Institute of Microbiology and a professor of molecular biology and biochemistry in the School of Arts and Sciences at Rutgers University-New Brunswick. “Antibiotic resistance is a huge problem in both medicine and agriculture, and continuing searches for new antibiotics are very important as they may provide leads for future anti-bacterial agents.”

Phazolicin

The bacterium that produces the antibiotic phazolicin forms nodules on bean plant roots, resulting in a more robust plant (right) than on the left. Credit: Dmitrii Y. Travin

The bacterium that produces phazolicin, is an unidentified species of Rhizobium. It was found in a tropical forest in Los Tuxtlas, Mexico, in the soil and roots of wild beans called Phaseolus vulgaris, hence the antibiotic’s name: phazolicin. Like other Rhizobia, the phazolicin-producing microbe forms nodules on bean plant roots and provides plants with nitrogen, making them grow more robustly than others. Unlike other Rhizobia, it also defends plants from harmful bacteria sensitive to phazolicin. The phenomenon could eventually be exploited in beans, peas, chickpeas, lentils, peanuts, soybeans and other legumes.

Using computer and bioinformatic analysis, the scientists predicted the existence of phazolicin and then confirmed its existence in the lab. They revealed the atomic structure of the antibiotic and showed it is bound to and targets the ribosome, a protein production factory in bacterial cells. The scientists found they can modify and control sensitivity, or susceptibility, to the antibiotic by introducing mutations in ribosomes.

Scientists from the Skolkovo Institute of Science and Technology in Russia; Russian Academy of Science; University of California, Berkeley; Lomonosov Moscow State University in Russia; University of Illinois at Chicago; and University Paris-Sud and University Paris-Saclay in France contributed to the study.

Reference: “Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition” by Dmitrii Y. Travin, Zoe L. Watson, Mikhail Metelev, Fred R. Ward, Ilya A. Osterman, Irina M. Khven, Nelli F. Khabibullina, Marina Serebryakova, Peter Mergaert, Yury S. Polikanov, Jamie H. D. Cate and Konstantin Severinov, 8 October 2019, Nature Communications.
DOI: 10.1038/s41467-019-12589-5

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