Researchers at the University of Queensland developed a new method to create mesenchymal stem cells (MSCs), which can be used to repair bone and potentially other organs. The technique could lead to the future widespread clinical use of MSCs.
University of Queensland scientists have developed a world-first method for producing adult stem cells that will substantially impact patients who have a range of serious diseases.
The research is a collaborative effort involving UQ’s Australian Institute for Bioengineering and Nanotechnology (AIBN) and is led by UQ Clinical Research Center’s (UQCCR) Professor Nicholas Fisk.
It revealed a new method to create mesenchymal stem cells (MSCs), which can be used to repair bone and potentially other organs.
“We used a small molecule to induce embryonic stem cells over a 10-day period, which is much faster than other studies reported in the literature,” Professor Fisk said.
“The technique also worked on their less contentious counterparts, induced pluripotent stem cells.
“To make the pluripotent mature stem cells useful in the clinic, they have to be told what type of cell they need to become (pre-differentiated), before being administered to an injured organ, or otherwise they could form tumors.
“Because only small numbers of MSCs exist in the bone marrow and harvesting bone marrow from a healthy donor is an invasive procedure, the ability to make our own MSCs in large numbers in the laboratory is an exciting step in the future widespread clinical use of MSCs.
“We were able to show these new forms of stem cells exhibited all the characteristics of bone marrow stem cells and we are currently examining their bone repair capability.”
AIBN Associate Professor and Co-Investigator on the project, Ernst Wolvetang said the new protocol had overcome a significant barrier in the translation of stem cell-based therapy.
“We are very excited by this research, which has brought together stem cell researchers from two of the major UQ research hubs UQCCR and AIBN,” Associate Professor Wolvetang said.
The research is published in the February edition of the STEM CELLS Translational Medicine journal.
Reference: “Small Molecule Mesengenic Induction of Human Induced Pluripotent Stem Cells to Generate Mesenchymal Stem/Stromal Cells” by Yen Shun Chen, Rebecca A. Pelekanos, Rebecca L. Ellis, Rachel Horne, Ernst J. Wolvetang and Nicholas M. Fisk, 7 February 2012, STEM CELLS Translational Medicine.