Following a novel treatment developed with the help of the Advanced Photon Source, paralyzed mice can now “walk” once again.
The Science Behind the Treatment
A new injectable treatment for spinal cord injury makes use of specially created molecules that prompt spinal cells to respond by healing. The scientists used X-ray characterization at the Advanced Photon Source (APS). This allowed the scientists to ascertain the structure of these molecules as they combined to create small fibers in a liquid solution.
These fibers’ motion may be controlled by scientists, making it possible for the fibers to interact with the spinal cells more effectively.
The Treatment’s Impact
Every year, hundreds of thousands of individuals have spinal injuries that often result in paralysis. For many years, researchers have been looking for a cure for these injuries. With only one dosage, this new injectable treatment reversed paralysis in mice after four weeks.
If it works the same way in people, individuals with serious spinal injuries could have a chance to walk once again. The techniques and approaches to characterization with X-rays could also help develop other therapeutic approaches requiring insights into the molecular structure.
A paralyzed mouse (left) drags its hind legs, compared to a paralyzed mouse that has regained its ability to move its legs after receiving Northwestern’s injectable therapy. Credit: Samuel I. Stupp Laboratory/Northwestern University
A critical portion of this research into a novel treatment for spinal injuries was conducted at the APS, a Department of Energy (DOE) Office of Science user facility at Argonne National Laboratory. There, scientists from Northwestern University and the Air Force Research Laboratories used ultrabright X-ray beams to study the structure of the engineered molecules and how they behaved together in a solution.
Injected as a liquid, the molecules came together to form tiny fiber structures (called nanofibers) that surrounded the spinal cord.
A simple animation shows how a single injection restores connections in the nervous system below the site of a severe spinal cord injury. Credit: Samuel I. Stupp Laboratory/Mark Seniw/Northwestern University
In the APS studies, the researchers discovered that the motion of molecules within the nanofibers could be controlled by changing their chemical structure. It turned out that molecules that moved most —“danced” more — were more likely to signal spinal cells via proteins called receptors, resulting in a more effective treatment.
Knowing the structure of the molecular matrix allowed researchers to tune the motion of the molecules. By making the molecules “dance,” they were more likely to find and engage cellular receptors, triggering the cells to repair damaged neurons.
Reference: “Bioactive scaffolds with enhanced supramolecular motion promote recovery from spinal cord injury” by Z. Álvarez, A. N. Kolberg-Edelbrock, I. R. Sasselli, J. A. Ortega, R. Qiu, Z. Syrgiannis, P. A. Mirau, F. Chen, S. M. Chin, S. Weigand, E. Kiskinis and S. I. Stupp, 11 November 2021, Science.
The study was funded by the Air Force Research Laboratory, the NIH/National Institute of Neurological Disorders and Stroke, the NIH/National Institute on Aging, the Les Turner ALS Foundation, the New York Stem Cell Foundation, the Paralyzed Veterans of America Research Foundation, the National Science Foundation, and the French Muscular Dystrophy Association.
I suffered a spine injury when I was 18, 43 years ago I am now 61. I would love to be part of this research you could use me as a guinea pig. I have nothing to lose, C3/4 incomplete quad!
Wow, great news. Brings a ray of hope to so many. To all involved in this research, please keep at it, and thanks for all your effort and dedication.
I am going into surgery soon for C 5/6, C6/7, would be interested to know if human studies have begun and what is needed to become a candidate?
Does this work for vertebrae breaks like Spondylolithesis?
I’ve had 3 surgeries on my c-3 down to the T-1,just had decompression in May. My left leg is slow and lazy,very weak and no stability. Walking with severe limp 22yrs,I’m 55yrs old
I’ve had a disc pop out in my L6 vertebrae in 2006. The cauda equina syndrome set in. If this can be reversed by the 1x treatment, I would gladly take it! Sell everything I own,or use me to test I out, whatever!
I absolutely will volunteer myself and my dead leg for human trials. Or tell me how much this treatment cost and I’ll come up with the money. My injury at the L3 occurred about 5 years ago and I’m willing to try just about anything.
Sehr geehrte Damen und Herren,
Ich schreibe im Namen meines Vaters. Er hatte vor 4 Jahren einen schweren Unfall und ist nun ab dem 3/4 Halswirbel Querschnittsgelähmt.
Ich versuche alles mir menschen mögliche um meinen Vater zu unterstützen. Mein Vater hat sich schon für das Gemini Projekt beworben, wo jedoch keinerlei Interesse gezeigt wird. Nun frage ich sie, ob Sie meinem Vater die Möglichkeiten geben könnten an dieser Studie bzw einer Studie teilzunehmen um seine Lauffähigkeit/Fühlvermögen wiederherzustellen.
Mit freundlichen Grüßen
Suffered a gunshot in 2015 in the chest and have been paralysed till now.This is indeed a ray of hope to us enduring paralysis.I know getting this treatment would be expensive looking at how living with paralysis is but please make this open to all(both those in US and around the world.We all need help because its not an easy situation to be in. I would be grateful if considered for this life changing opportunity. Its not easy living with disability.
I have an incomplete SCI th6. I’m 26 years old and got my life ruined because of this injury. My relationship and life crashed, can’t even play with my newborn son. I’m willing to pay whatever this costs. Would be great for me and for the others who suffer from this type of injury. Just contact me on my email
I want to volunteer for this experiment. I suffer a th6 SCI (incomplete). I am 26 years old and lives in Sweden.
Please update me on this. God bless y’all
There doesn’t seem to be anything new on this subject since it was announced in the latter part of 2021. At that time human trials were expected to begin in early 2022. Is there a timeline you can reference?
I suffered a c5-c6 injury 30 years ago and have recovered from paralysis that lasted 5 weeks to the extent of maybe 75-80% I have weaknesses and dexterity on my left side leg, arm and hand. Am I a candidate for this treatment when it becomes a trial?
When do the trials start and how do I get involved? I want to volunteer for them. I am paralyzed from waist down 2 yrs now, T12 injury. found nothing on clinicaltrials. Please contact me with any info.
C7 spinal cord injury wanting to be used for tryout on human praying for start on humans trial I know God is able
I was paralysed in 2015.am c6/c7 compressed. Am now 51yrs old. This is a very welcome development. It is satisfying that paralysis would soon be a thing of the past. I would very much like to volunteer for the clinical trial. If only it is possible for everyone to get on the trial. Please email me if considered. Thank you.
I am victim of spinal cord injury since 2013, incomplete injury between C4 and C5 level, quadruplegic since, and I would love and appreciate to be part and I am volunteer for the clinical trial
This is great news.My heart goes out to all that help out those in need My youngest was paralyzed after a car accident at 21 a graduate cadet fireman and Emt he loved being able to care for others Regardless this young man has the drive that few have with his condition This has changed all our lives and I can say he is an inspiration to me and others by never giving up I also sufferd my loss of my right arm at a very young age at work and did my best to get through in life with what I had to do.We would love to be a part of this new discovery if possible please contact us if possible My name is Carlos Hernandez and my son is Israel M Hernandez Thank You
I just wanted to know that why the progression of this reasearch stopped I and so many people are waiting for the treatment to start. I look for it daily on internet to see what’s the latest news about dancing molecules. Please go for the clinical trials and make treatment available for millions of people who are living a miserable life.please do it fast🙏
I suffered a stroke 3 years ago which left me a paraplegic. This is very exciting and I would be very interested in participating in the human clinical trials once they begin.
Any new updates on when clinical trials will begin? I would be very interested in joining them as I have been a paraplegic for 4 years now due to a stroke during a brain tumor removal.