Researchers have developed a new, safer, and more economical method for producing acetone using light and a photoactive iron chloride catalyst, simplifying the process and reducing the need for high-temperature, high-pressure steps. This innovation could revolutionize acetone production by using sunlight and scaling up for industrial use, promising enhanced safety and sustainability.
Acetone, a key input for the chemical industry, is traditionally manufactured through a complex and risky procedure. Researchers from Brazil and Germany have collectively forged a more eco-friendly approach.
Acetone plays a pivotal role in the chemical industry, serving as a critical component in the creation of diverse products including adhesives, antibiotics, electronic parts, solvents, paint removers, inks, and vitamins. However, its production is complex and hazardous. To simplify the process and make it safer and cheaper, researchers in Brazil and Germany have developed an innovative method that uses only light and photoactive iron chloride (FeCl3), an inexpensive chemical compound.
An article on the research, which was funded by FAPESP, was recently published in the journal ACS Catalysis.
The standard acetone manufacturing process, known as the Hock or cumene process, comprises several stages. Propane, a petroleum product, is converted to propylene, a highly flammable gas, which is reacted with benzene and then with oxygen at high temperatures and pressures to give rise to acetone. These reactions also produce phenol, a compound for which there is less demand but which can be converted to value-added substances, although this is costly.
The alternative method developed by scientists affiliated with the Federal University of São Carlos (UFSCar) and the Federal University of Minas Gerais (UFMG) in Brazil, in collaboration with colleagues at the Max Planck Institute of Colloids and Interfaces in Germany, is based on propane oxidation and a photocatalytic reaction using iron chloride as a homogeneous catalyst in the presence of light.
The alternative strategy is based on oxidation of propane using iron chloride as a homogeneous catalyst in the presence of light. Credit: Vitor Gabriel Pastana
“We discovered that when iron chloride is irradiated at certain wavelengths, it produces the radical chlorine, which is a potent oxidant and cleaves the bond between carbon and hydrogen [activates the C-H bond], giving rise to a radical that leads in the presence of oxygen to the formation of acetone,” said Ivo Freitas Teixeira, a professor in UFSCar’s Department of Chemistry and last author of the article. “We achieved a very important reaction in an absolutely different manner and using very simple elements.”
Proof that the reaction was genuinely driven by chlorine radicals produced by Fe-Cl photolysis was obtained by means of mechanistic studies, including mass spectrometry, an analytical technique that identifies the components of a mixture by determining the molecular weight of their particles.
Among the advantages of the process is the fact that it is direct – skipping the production of propylene in intermediate stages – and safer as it does not involve oxygen reactions at high temperatures and pressures or flammable and hazardous intermediaries. In addition, it lowers energy consumption and cost because it has fewer stages and occurs at room temperature (25 °C).
The experiments used light-emitting diodes (LEDs) as a light source, but the researchers plan to use sunlight instead in the future, making the method even more sustainable.
Patent application and next steps
A patent application has been filed with the National Industrial Property Institute (INPI), Brazil’s patent office, and partnerships with companies are being sought to scale up and commercialize the new process. “It could become absolutely disruptive for acetone production in the chemical industry, enhancing safety and sustainability, and paving the way to direct production of acetone, which would cut costs and increase competitiveness,” Teixeira said.
The main challenges, he added, are the large scale of processes in the petrochemical industry, and the fact that as yet there are no commercial photocatalysis methods.
The research also continues to develop in two directions: testing of the new method with other substances, such as methane; and seeking ways to scale up the process so as to increase industrial production and yield.
Reference: “Direct Synthesis of Acetone by Aerobic Propane Oxidation Promoted by Photoactive Iron(III) Chloride under Mild Conditions” by Andrea Rogolino, José B. G. Filho, Lorena Fritsch, José D. Ardisson, Marcos A. R. da Silva, Gabriel Ali Atta Diab, Ingrid Fernandes Silva, Carlos André Ferreira Moraes, Moacir Rossi Forim, Matthias Bauer, Thomas D. Kühne, Markus Antonietti and Ivo F. Teixeira, 15 June 2023, ACS Catalysis.
DOI: 10.1021/acscatal.3c02092
The study was funded by the São Paulo Research Foundation.
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