Scientists Have Uncovered Remarkable Similarities Between This Sea Monster and Humans

Sea Lamprey Sucking Mouth

Recent research has discovered that sea lampreys and humans share a similar genetic blueprint for hindbrain development, highlighting the evolutionary connection between jawless and jawed vertebrates and underscoring the role of retinoic acid in this ancient developmental pathway.

Scientists at Stowers Institute have revealed that the brain development in sea lampreys shows striking similarities to human brain development.

The sea lamprey, an ancient creature dating back 500 million years with a mouth resembling a sharp-toothed suction cup, seems like it’s straight out of a horror story. Recent research from the Stowers Institute for Medical Research has revealed that the hindbrain, which governs crucial functions such as blood pressure and heart rate, in both sea lampreys and humans, is constructed using a remarkably similar set of molecular and genetic tools.

Research from the lab of Investigator Robb Krumlauf, Ph.D., recently published in Nature Communications offers a glimpse into how the brains of ancient animals evolved. The team unexpectedly uncovered that a crucial molecular cue is very broadly required during vertebrate hindbrain development. 

“This study on the hindbrain is essentially a window into the distant past and serves as a model for understanding the evolution of complexity,” said co-author Hugo Parker, Ph.D.

Sea Lamprey Montage

Top and left images are adult sea lampreys. On the right is a fluorescence microscopy image of a developing sea lamprey embryo. Credit: Stowers Institute for Medical Research

Unique Features of Sea Lampreys

Like other vertebrate animals, sea lampreys have a backbone and skeleton, but they are noticeably missing a feature of their heads—a jaw. Because most vertebrates, including humans, have jaws, this striking difference in sea lampreys makes them valuable models for understanding the evolution of vertebrate traits.  

“There was a split at the origin of vertebrates between jawless and jawed around 500 million years ago,” said Alice Bedois, Ph.D., a former predoctoral researcher in the Krumlauf Lab and lead author on the study. “We wanted to understand how the vertebrate brain evolved and if there was something unique to jawed vertebrates that was lacking in their jawless relatives.”  

A team of scientists from the Stowers Institute discovered that the hindbrain—the part of the brain controlling vital functions like blood pressure and heart rate—of both sea lampreys and humans is built using an extraordinarily similar molecular and genetic toolkit. Credit: Stowers Institute for Medical Research

Previous work from the Krumlauf Lab and the lab of Marianne Bronner, Ph.D., at the California Institute of Technology had identified that the genes structuring and subdividing the sea lamprey hindbrain are identical to those in jawed vertebrates including humans.  

However, these genes are part of an interconnected network or circuit that needs to be initiated and directed to build the hindbrain correctly. The new study identified a common molecular cue, while known to direct head-to-tail patterning in a wide variety of animals, as part of the gene circuitry guiding hindbrain patterning in sea lampreys. 

“We found that not only are the same genes but also the same cue is involved in sea lamprey hindbrain development, suggesting this process is ancestral to all vertebrates,” said Bedois.    

Discovery of Retinoic Acid’s Role

This cue is called retinoic acid, commonly known as vitamin A. While the researchers knew that retinoic acid cues the gene circuitry to build the hindbrain in complex species, it was not thought to be involved in more primitive animals like sea lampreys. Surprisingly, they found that the sea lamprey core hindbrain circuit is also initiated by retinoic acid, providing evidence that these sea monsters and humans are much more closely related than anticipated.  

“People thought that because sea lampreys lack a jaw, their hindbrain was not formed like other vertebrates,” said Krumlauf. “We have shown that this basic part of the brain is built in exactly the same way as mice and even humans.”  

There are well-known signaling molecules that inform the fate of cells during development. Now, the researchers have found that retinoic acid is another major player that cues vital steps in development like the formation of the brain stem. In addition, if hindbrain formation is a conserved feature for all vertebrates, other mechanisms must be responsible to explain their incredible diversity.  

“We all derived from a common ancestor,” said Bedois. “Sea lampreys have provided an additional clue. Now we need to look even further back in evolutionary time to discover when the gene circuitry governing hindbrain formation first evolved.”   

Reference: “Sea lamprey enlightens the origin of the coupling of retinoic acid signaling to vertebrate hindbrain segmentation” by Alice M. H. Bedois, Hugo J. Parker, Andrew J. Price, Jason A. Morrison, Marianne E. Bronner and Robb Krumlauf, 20 February 2024, Nature Communications.
DOI: 10.1038/s41467-024-45911-x

This work was funded by the National Institute of Neurological Disorders and Stroke (award: R35NS111564) of the National Institutes of Health (NIH) and by institutional support from the Stowers Institute for Medical Research. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. 

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