Scientists Warn That UV-Emitting Nail Polish Dryers Damage Human DNA and Cause Mutations

Cells Being Exposed to a UV Nail Polish Dryer

Researchers at UC San Diego studied the UV light-emitting devices used to cure gel manicures, and found that the chronic use of these nail polish drying machines is damaging to human cells. Credit: David Baillot/ UC San Diego Jacobs School of Engineering

The ultraviolet nail polish drying devices used to cure gel manicures may pose more of a public health concern than previously thought. Researchers at the University of California San Diego studied these ultraviolet (UV) light-emitting devices, and found that their use leads to cell death and cancer-causing mutations in human cells.

The devices are a common fixture in nail salons, and generally use a particular spectrum of UV light (340-395nm) to cure the chemicals used in gel manicures. While tanning beds use a different spectrum of UV light (280-400nm) that studies have conclusively proven to be carcinogenic, the spectrum used in the nail dryers has not been well studied.

“If you look at the way these devices are presented, they are marketed as safe, with nothing to be concerned about,” said Ludmil Alexandrov, a professor of bioengineering as well as cellular and molecular medicine at UC San Diego, and corresponding author of the study published on January 17 in the journal Nature Communications. “But to the best of our knowledge, no one has actually studied these devices and how they affect human cells at the molecular and cellular levels until now.”

Using three different cell lines– adult human skin keratinocytes, human foreskin fibroblasts, and mouse embryonic fibroblasts– the researchers found that the use of these UV emitting devices for just one 20-minute session led to between 20 and 30 percent cell death, while three consecutive 20-minute exposures caused between 65 and 70 percent of the exposed cells to die.

Maria Zhivagui in Lab

Maria Zhivagui, a postdoctoral scholar in the Alexandrov Lab and first author of the study, prepares human cells in Petri dishes for exposure to the manicure curing device. Credit: David Baillot/ UC San Diego Jacobs School of Engineering

Exposure to the UV light also caused mitochondrial and DNA damage in the remaining cells and resulted in mutations with patterns that can be observed in skin cancer in humans.

“We saw multiple things: first, we saw that DNA gets damaged,” said Alexandrov. “ We also saw that some of the DNA damage does not get repaired over time, and it does lead to mutations after every exposure with a UV-nail polish dryer. Lastly, we saw that exposure may cause mitochondrial dysfunction, which may also result in additional mutations. We looked at patients with skin cancers, and we see the exact same patterns of mutations in these patients that were seen in the irradiated cells.”

The researchers caution that, while the results show the harmful effects of the repeated use of these devices on human cells, a long-term epidemiological study would be required before stating conclusively that using these machines leads to an increased risk of skin cancers. However, the results of the study were clear: the chronic use of these nail polish drying machines is damaging to human cells.

Maria Zhivagui, a postdoctoral scholar in the Alexandrov Lab and first author of the study, used to be a fan of gel manicures herself, but has sworn off the technique after seeing the results.

“When I was doing my PhD, I started hearing about gel manicures, which last longer than normal polish. I was interested in trying out gel nail polish, particularly in the setting of working in an experimental lab where I frequently put gloves on and off, to maintain a presentable appearance,” said Zhivagui. “So I started using gel manicures periodically for several years. Once I saw the effect of radiation emitted by the gel polish drying device on cell death and that it actually mutates cells even after just one 20-minute session, I was surprised. I found this to be very alarming, and decided to stop using it.”

Studying their effect on human cells

The idea to study these particular devices came to Alexandrov in a dentist’s office, of all places. As he waited to be seen, he read a magazine article about a young beauty pageant contestant who was diagnosed with a rare form of skin cancer on her finger.

“I thought that was odd, so we began looking into it, and noticed a number of reports in medical journals saying that people who get gel manicures very frequently– like pageant contestants and estheticians– are reporting cases of very rare cancers in the fingers, suggesting that this may be something that causes this type of cancer,” said Alexandrov. “And what we saw was that there was zero molecular understanding of what these devices were doing to human cells.”

Nail Polish Curing Device

Three cell types were exposed to two different conditions: acute exposure and chronic exposure to the UV light device, pictured here. Credit: David Baillot/ UC San Diego Jacobs School of Engineering

To conduct the study, Zhivagui exposed the three cell types to two different conditions: acute exposure and chronic exposure to the UV light device. Under acute exposure, Petri dishes containing one of the cell types were placed in one of these UV curing machines for a 20-minute session. They were then taken out for an hour to repair or return to their steady state, and then given one more 20-minute exposure. Under chronic exposure, the cells were placed under the machine for 20 minutes a day for three days.

Cell death, damage and DNA mutations were seen under both conditions, with an elevation of reactive oxygen species molecules– known to cause DNA damage and mutations– and mitochondrial dysfunction in the cells. Genomic profiling revealed higher levels of somatic mutations in the irradiated cells, with patterns of mutations ubiquitously present in melanoma patients.

Is the risk worth the reward?

This data in human cells, coupled with a number of prior reports of cancers in people who get gel manicures very frequently, paint a picture of a purely cosmetic procedure that is riskier than previously believed. But is getting a gel manicure once a year really cause for concern, or should only those who get this done on a very regular basis be worried? Further studies are needed to quantify any increased risk of cancer and at what frequency of use, but with plenty of alternatives to this cosmetic procedure, the risk may not be worth it to some consumers.

“Our experimental results and the prior evidence strongly suggest that radiation emitted by UV-nail polish dryers may cause cancers of the hand and that UV-nail polish dryers, similar to tanning beds, may increase the risk of early-onset skin cancer,” they write. “Nevertheless, future large-scale epidemiological studies are warranted to accurately quantify the risk for skin cancer of the hand in people regularly using UV-nail polish dryers. It is likely that such studies will take at least a decade to complete and to subsequently inform the general public. ”

Though other consumer products use UV light in the same spectrum– including the tool used to cure dental fillings and some hair removal treatments– the researchers note that the regularity of use, plus the entirely cosmetic nature of nail dryers, sets them apart.

Reference: “DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer” by Maria Zhivagui, Areebah Hoda, Noelia Valenzuela, Yi-Yu Yeh, Jason Dai, Yudou He, Shuvro P. Nandi, Burcak Otlu, Bennett Van Houten and Ludmil B. Alexandrov, 17 January 2023, Nature Communications.
DOI: 10.1038/s41467-023-35876-8

7 Comments on "Scientists Warn That UV-Emitting Nail Polish Dryers Damage Human DNA and Cause Mutations"

  1. Fei Lynn Pritty | January 20, 2023 at 11:23 am | Reply

    The mutagenicity of UV light is well known and studied and exposure is an expected risk.
    If “1 20-minute session led to between 20-30% cell death, 3 20-minute exposures caused 65-70% of the exposed cells to die”, I think people would notice if 20-70% of their hands died. If it caused as much damage as even a sunburn, people would notice.

    The spectrum used in the nail salon “(340-395nm)” is within the tanning bed spectrum “(280-400nm)”, and both are nominal as the lamps won’t be within a tolerance of 5nm; note the shades of visible blue in the photos of the manicure lamp, where visible violet starts at 380nm and the blue is up to 500nm.

  2. After all the research I’ve done over the last 10 years, I’m prone to think that any time they come out and tell you something is bad for you, I’m thinking there’s an agenda so I start searching for the “why”. Looks like they need some things to blame the DNA damage from the vaccines on so now comes the smear campaigns for everything they can think of. Not buying any of it. Keep an eye on the articles that will come out over the next six months, you’ll start to see a pattern.

  3. I’ll bullsh*t

    • Taking it in but confused | January 22, 2023 at 1:00 am | Reply

      RIGHT?! Also I have just been thinking like “who is putting their hands n feet n a machine for 20 min at a time????” That is a LONG time!!!! My nail technician does at most 6 min (4 – 45 sec on feet and hands, respectively) and that every 4-8 weeks! I think they need to also look at realistically how long people use it and then redo this experiment. I could be alil off but 20 min session with your hand/feet under UV light sounds unrealistic.

  4. I used to have my nails done regularly and I developed a rare type of dermatitis ( on my hands) even the specialist couldn’t probably diagnose it. I suspect it is from the use of these UV machines

  5. The idea of using cosmetic UV nail polish dryers is now old, as the first paper published on this topic goes back to almost 7 years ago, on immortalized human keratinocytes (Petruk, Ganna, et al. “An ascorbic acid-enriched tomato genotype to fight UVA-induced oxidative stress in normal human keratinocytes.” Journal of Photochemistry and Photobiology B: Biology 163 (2016): 284-289).

    Moreover, devastating effects were found after 2 min of exposure.

    Readers were already warmed on the damaging effects of this commonly used apparatus.

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