CryoEM News

Cryo-electron microscopy (CryoEM) is a revolutionary technique in structural biology that allows for the visualization of biological molecules in near-native states at atomic resolutions. This method involves rapidly freezing biological samples in a way that preserves their natural structure without the need for dyes or fixatives. The frozen samples are then imaged with an electron microscope, which captures thousands of projections that are computationally combined to produce high-resolution three-dimensional structures of complex proteins, viruses, and other cellular components.

A How-To Guide to Designing Cancer Drugs

Scripps Research scientists have identified how the structure of the PI3Kα protein changes in cancer cells, providing insight into potential drug-targeting strategies. Understanding the structure…