Yale Scientists Explore the Role of Glucose Metabolism in Malaria
More than one million people die annually from cerebral malaria, the most lethal form of the disease. A recent study, led by Yale investigators, explores…
Medicine
Scientists Use Gene Therapy to Successfully Treat Mitochondrial Diseases
Mitochondrial disease is now thought to be the second most commonly diagnosed genetic disease worldwide, and, unfortunately, there are still no proven treatment strategies for…
Scientists Reveal the Key to Stem Cell Self-Renewal
Every skin cell on the human body is replaced weekly, with stem cells generating billions of specialized progeny that engage in an orchestrated scramble to…
Artificial Intelligence Improves Drug Combination Design
A new auto-commentary published in SLAS Technology looks at how an emerging area of artificial intelligence, specifically the analysis of small systems-of-interest specific datasets, can…
Protein ASTN2 Provides New Insight Into Autism and Other Brain Disorders
In the brain, as in business, connections are everything. To maintain cellular associates, the outer surface of a neuron, its membrane, must express particular proteins—proverbial…
Scientists Provide New Insights Into the Origins of Genetic Diseases
A three-dimensional map showing an actin filament (blue) bound to a fragment of the cross-linking protein, filamin A (green). For human cells to form and…
New Molecular Details of Cancer Cells Could Lead to Improved Treatment
Uncovered details of a molecular pathway in cancer cells could lead to improved treatment. Targeting a pathway that controls the movement of mitochondria, the powerhouses…
Physical Exercise Improves Cognition in Alzheimer’s Disease
A study by a Massachusetts General Hospital (MGH) research team finds that neurogenesis — inducing the production of new neurons — in the brain structure…
A New Model for Chronic Disease Pathogenesis and Treatment
Much of modern Western medicine is based upon the treatment of acute, immediate harm, from physical injury to infections, from broken bones and the common…
New Research Shows How Sickled Red Blood Cells Clump Together
One of the most common complications of sickle-cell disease occurs when deformed red blood cells clump together, blocking tiny blood vessels and causing severe pain…
Scientists Discover How Microenvironments Regulate Stem Cell Development
Researchers from the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Jonsson Comprehensive Cancer Center have discovered an important…
Researchers Discover How to Stop Cell Death Associated with Multiple Diseases
Researchers from Case Western Reserve University School of Medicine have discovered a way to stop immune cell death associated with multiple diseases, including sepsis, inflammatory…
New Imaging Technique Captures Detailed Information About Metabolism
Yale researchers have developed a new imaging technique that captures detailed information about metabolism, which plays a role in many diseases. The novel yet simple…
Scientists Close In On Mystery Surrounding Dangerous Blood Syndromes
Scientists may be on the road to solving the mystery of a group of mostly incurable blood diseases called myelodysplastic syndromes (MDS), which cause people…
Scientists Reveal Cellular Changes That Lead to Chronic Allergic Inflammation
Findings suggest mechanisms for the persistence of nasal polyps and possible new treatment strategies. Chronic rhinosinusitis is distinct from your average case of seasonal allergies….
CRISPR’s Potential and Dangers: Is CRISPR Worth the Risk?
The gene editing technology CRISPR has prompted both breathless predictions of medical breakthroughs and warnings of apocalypse. Yale Insights asked Dr. Greg Licholai, a biotech…
New Study Shows Dehydration Alters Human Brain Shape and Activity
When dehydration strikes, part of the brain can swell, neural signaling can intensify, and doing monotonous tasks can get harder. With the help of brain…
MIT Scientists Discover New Antibiotic Candidates
The human body produces many antimicrobial peptides that help the immune system fend off infection. Scientists hoping to harness these peptides as potential antibiotics have…