Scientists show that lecanemab clears amyloid plaques by engaging microglia through its Fc fragment, defining…
Browsing: Microglia
Microglia are specialized cells within the brain and spinal cord that function as the primary immune defenders of the central nervous system. These glial cells constantly survey their environment to identify and eliminate pathogens, clear damaged neurons and cellular debris, and support neural development. Microglia can change shape and function in response to various signals and injuries, playing a critical role in inflammation and contributing to the maintenance of neural circuits. Their activity is pivotal in various physiological processes but can also contribute to neurodegenerative diseases, such as Alzheimer’s disease, under conditions of chronic inflammation or dysregulation. Understanding microglia is essential for developing therapies targeting brain health and disease.
Alzheimer’s may advance by breaking the brain’s internal clock—and resetting it could help fight the…
Scientists have found a special group of microglia (brain immune cells) that can help protect…
TSPO levels rise early in Alzheimer’s and persist throughout disease. Targeting this biomarker could open…
Immune-driven nerve fiber damage may underlie early smell loss in Alzheimer’s, offering a new path…
A study in rats questions long-standing views on hypertension and suggests the brain may serve…
Scientists have found that microglia play a crucial role in regulating the number of cells…
Germ-free larvae have altered neural connections due to a reduction in pruning by immune cells.…
Gut microbes enable brain pruning critical for social behavior, linking microbiomes to brain function across…
UVA scientists found that microglia not only guard the brain but also control blood flow…
Microglia are brain cells, whose spider-like resting state was somewhat mysterious until Axel Nimmerjahn, biophysicist…
Rett syndrome, a severe autism spectrum disorder, which affects roughly 1 girl in 10,000 to…