Compound in the Herb Rosemary Could Be a Two-Pronged Weapon Against COVID-19
Scientists find evidence that carnosic acid can block SARS-CoV-2 infection and reduce inflammation. A team co-led by scientists at Scripps Research has found evidence that…
Scripps Research Institute News
How Toxic Aggregates Form and Kill Brain Cells in Prion Diseases
Scripps Research Discovery Illuminates How Brain Cells Die in Prion Diseases Researchers show how toxic aggregates are formed inside brain cells, and how to block…
Scientists Discover New Method From Nature for Installing Sulfur Into Complex Molecules
Advance provides new tools for synthetic chemists and biologists looking to probe and modify sulfur-based biochemistry. A group of highly reactive compounds called persulfides have…
Extensive Study Identifies Over a Dozen Existing Drugs As Potential Treatments for COVID-19
FDA-approved drugs or experimental drugs with ample health data could be rapidly tested in humans as COVID-19 therapies. Mining the world’s most comprehensive drug repurposing…
Experimental Antibodies for Parkinson’s and Alzheimer’s May Cause Harmful Inflammation
Scientists find evidence that antibody-based treatments in clinical trials for neurodegenerative diseases may trigger an inflammatory response in human brain immune cells, eroding their positive…
Discovery Supports a Surprising New View of How Life on Earth Originated
Discovery boosts theory that life on our planet arose from RNA-DNA mix. Chemists at Scripps Research have made a discovery that supports a surprising new…
Breaking COVID-19’s “Clutch” to Stop Its Spread: Small Molecule Targets SARS-CoV-2 RNA for Destruction
Researchers engineer RNA-targeting compounds that disable the pandemic coronavirus’ replication engine. Scripps Research chemist Matthew Disney, PhD, and colleagues have created drug-like compounds that, in…
Common Molecular Feature of Antibodies That Neutralize SARS-CoV-2 Discovered, Boosting COVID-19 Vaccine Prospects
The findings support many vaccine strategies being used to tackle the new coronavirus. A team led by scientists at Scripps Research has discovered a common…
Flu Mutation Study: Universal Flu Vaccine May Be More Challenging Than Expected
Many flu strains may be capable of mutating to escape universal-vaccine antibodies. Some common strains of influenza have the potential to mutate to evade broad-acting…
“Silent” Carriers: Extraordinary Percentage of SARS-CoV-2 Coronavirus Infections May Be Asymptomatic
Analysis of data from 16 groups of COVID-19 patients suggest ‘silent’ carriers may exacerbate efforts to stop spread of the disease. An extraordinary percentage of…
Century-Old Scientific Debate Settled: Anesthesia’s Effect on Consciousness Solved
Billiard-like break shot to cell-membrane structures triggers brain’s loss of consciousness from anesthesia, scientists find. Surgery would be inconceivable without general anesthesia, so it may…
Your Computer Can Help Scientists Searching for COVID-19 Treatments
IBM’s World Community Grid hosts Scripps Research project to virtually screen chemical compounds that might help fight COVID-19. Under a collaboration between IBM and Scripps…
Potential Vulnerability of COVID-19 Coronavirus Discovered From an Antibody Against SARS
A Scripps Research study reveals a likely site of vulnerability on the SARS-CoV-2 virus. An antibody recovered from a survivor of the SARS epidemic in…
No Evidence COVID-19 Coronavirus Was Genetically Engineered in a Lab – Epidemic Has a Natural Origin
Scripps Research’s analysis of public genome sequence data from SARS-CoV-2 and related viruses found no evidence that the virus was made in a laboratory or…
Unexpected Approach Is Chemistry ‘Warp Drive’ for Creating Better Synthetic Molecules for Medicine
An unexpected approach blurs the line between synthetic drug molecules and natural products, with the goal of achieving higher quality compounds for medicines. In a…
Recently Discovered Protein Has Important Role in Obesity and Diabetes
The little-known protein is normally abundant in fat; without it, the body struggles to manage glucose and insulin. With unexpected findings about a protein that’s…
New Medicines & ‘Green’ Insecticides Possible With Efficient Synthesis of Ginkgo Compound
New method offers an easy route for making bilobalide and related compounds so scientists can explore their potential uses as drugs and pesticides. Chemists at…
How Did Cells Originally Form Billions of Years Ago? Scientists Identify Molecule That May Be Key to Emergence of Life on Earth.
Compounds called cyclophospholipids would have held up against the planet’s harsh conditions, helping the first cells form and proliferate. Researchers must dissect the building blocks…
