A How-To Guide to Designing Cancer Drugs
Scripps Research scientists have identified how the structure of the PI3Kα protein changes in cancer cells, providing insight into potential drug-targeting strategies. Understanding the structure…
Scripps Research scientists have identified how the structure of the PI3Kα protein changes in cancer cells, providing insight into potential drug-targeting strategies. Understanding the structure…
A key property needed for the effectiveness of CELMoD drugs, a type of protein degrader, has been discovered. Scripps Research Institute scientists have discovered a…
Scripps Research and MIT scientists find that a modified immune protein harming brain connections is much more common in the brains of women with Alzheimer’s,…
Researchers at Scripps Research examined how the levels of various proteins in brain cells change in response to brain activity. Scripps Research Institute scientists have…
The Scripps Research team demonstrated that a variant of an existing FDA-approved treatment for neurological disorders may prevent COVID-19 infection in animals. Scientists at Scripps…
Scripps Research and Calibr scientists collaborated to discover potential therapeutic treatments for metabolic diseases. “Metabolism” describes the body’s chemical changes that create the necessary ingredients…
A new analysis finds that deadly Lassa fever could soon become a much bigger public health problem in Africa due to climate change and other…
The reaction generates the building blocks of proteins and DNA: amino acids and nucleic acids. Four billion years ago, the Earth looked very different than…
Scripps Research technique makes it easier to analyze body-wide biological processes and diseases such as COVID-19 infection. Scientists at Scripps Research have unveiled a new…
Study shows how blocking cellular housekeeping system leads to buildup and spread of abnormal protein aggregates in the brain. Parkinson’s disease may be driven in…
Scientists find evidence that carnosic acid can block SARS-CoV-2 infection and reduce inflammation. A team co-led by scientists at Scripps Research has found evidence that…
Scripps Research Discovery Illuminates How Brain Cells Die in Prion Diseases Researchers show how toxic aggregates are formed inside brain cells, and how to block…
Advance provides new tools for synthetic chemists and biologists looking to probe and modify sulfur-based biochemistry. A group of highly reactive compounds called persulfides have…
FDA-approved drugs or experimental drugs with ample health data could be rapidly tested in humans as COVID-19 therapies. Mining the world’s most comprehensive drug repurposing…
Scientists find evidence that antibody-based treatments in clinical trials for neurodegenerative diseases may trigger an inflammatory response in human brain immune cells, eroding their positive…
Discovery boosts theory that life on our planet arose from RNA-DNA mix. Chemists at Scripps Research have made a discovery that supports a surprising new…
Researchers engineer RNA-targeting compounds that disable the pandemic coronavirus’ replication engine. Scripps Research chemist Matthew Disney, Ph.D., and colleagues have created drug-like compounds that, in…
The findings support many vaccine strategies being used to tackle the new coronavirus. A team led by scientists at Scripps Research has discovered a common…