Neural Inhibition – Neuroscientists Unveil Potential PTSD and Alcohol Use Disorder Treatment

Alcohol Addiction Concept

Neuroscientists at Scripps Research discovered that inhibiting stress-related neurons could reduce alcohol consumption in individuals with PTSD and AUD, without affecting trauma-related anxiety. Published in Molecular Psychiatry, this study illuminates the complex interactions between stress, trauma, and neurological disorders, offering new paths for treatment.

A team from Scripps Research has demonstrated that reducing the activity of specific stress neurons may lead to a decrease in alcohol consumption without affecting anxiety levels in individuals with co-occurring post-traumatic stress disorder and alcohol use disorder.

Neuroscientists at Scripps Research have discovered that targeting neurons linked to the body’s stress response could lower alcohol intake in individuals suffering from both post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD)—even if they still experience trauma-related anxiety.

The findings were recently published in Molecular Psychiatry. These discoveries are helping untangle the complex role that stress and trauma play in neurological disorders like PTSD and AUD, while also informing the development of new treatment options for people who experience both these conditions simultaneously.

“Traumatic experiences in life can increase vulnerability to alcohol drinking and exacerbate symptoms of depression and anxiety,” says senior author Marisa Roberto, PhD, the Schimmel Family Endowed Chair and vice chair of the Department of Molecular Medicine. “Alcohol is often used as a coping strategy to blur trauma-associated memories and diminish negative emotional states.”

PTSD and AUD are often comorbid, so understanding their underlying neurological mechanisms in tandem is crucial. About 6% of the U.S. population will develop PTSD at some point, according to the U.S. Department of Veterans Affairs, and people with PTSD have a 30% lifetime prevalence of AUD. However, few pharmaceutical therapies exist to treat the disorders together.

Research Methodology and Findings

Roberto’s team previously created a model in which rats develop symptoms similar to what people with comorbid PTSD and AUD experience: aggression, anxiety, hyperarousal, disturbed sleep, and increased alcohol consumption. In this new study, they compared these rats with those that did not exhibit anxiety-like behaviors by giving each group access to both alcohol and water.

Compared with unstressed rats, those that were stressed exhibited higher levels of peripheral stress hormones, and various genes in the central amygdala, including one that encodes for the neuropeptide known as corticotropin-releasing factor (CRF), were also shown to be altered in stressed rats.

CRF exists in the central amygdala, a part of the brain that’s altered by excessive drinking and is responsible for processing fear. Stress causes neural release of CRF, which plays a key role in regulating physiological responses to the emotion. Prior research with rats has shown that inhibiting neurons that express CRF reduces alcohol consumption.

CRF Inhibition and Alcohol Consumption

After identifying that the stressed rats expressed higher levels of CRF in the amygdala, the researchers then inhibited CRF-producing neurons in the stressed group. As expected, they found that this decreased alcohol consumption—but it didn’t mitigate anxiety as they initially thought it would.

“We were surprised to see that the anxiety phenotypes were not reduced when silencing CRF expressing neurons in the central amygdala, suggesting other neuropeptide co-factors might be at play,” says the study’s first author, Bryan Cruz, PhD, a postdoctoral fellow at Scripps Research.

The results suggest that CRF plays a role in alcohol use among those with comorbid PTSD and AUD. Still, the researchers conclude that future studies need to disentangle the neurological mechanisms behind stress-related alcohol consumption and trauma-induced anxiety.

“Understanding the neurobiology of PTSD-AUD is key for the development of future intervention strategies for this devastating comorbidity,” says Roberto. “We speculate that other neuropeptides with anti-stress properties may be involved in PTSD-AUD.”

Reference: “Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder” by Bryan Cruz, Valentina Vozella, Vittoria Borgonetti, Ryan Bullard, Paula C. Bianchi, Dean Kirson, Luisa B. Bertotto, Michal Bajo, Roman Vlkolinsky, Robert O. Messing, Eric P. Zorrilla and Marisa Roberto, 21 March 2024, Molecular Psychiatry.
DOI: 10.1038/s41380-024-02514-8

This work and the researchers involved were supported by funding from the National Institute on Alcohol Abuse and Alcoholism (grants AA027700, AA013498, P60 AA006420, AA017447, AA021491, AA029841, AA028879, AA029498, K99 AA026638, K99 AA030609, T32 AA007456, and AA02675) and the Schimmel Family Chair and Pearson Center for Alcoholism and Addiction Research.

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