Unveiling the Dawn of Complex Life: How a Simple Creature Set the Stage for Human Evolution

Adult Mayfly

A groundbreaking study reveals that a simple creature from 700 million years ago, the ancestor to all bilaterians, established a body plan and genetic legacy that has significantly influenced the evolutionary trajectory of complex animals through the specialized adaptation of ancient genes. The image above depicts a mayfly, one of the 20 species studied in the paper. Credit: Isabel Almudi

Gene duplication events hundreds of millions of years ago contributed to evolutionary innovations such as insect flight, octopus camouflage, and human cognition.

700 million years ago, a remarkable creature emerged for the first time. Though it may not have been much to look at by today’s standards, the animal had a front and a back, a top and a bottom. This was a groundbreaking adaptation at the time, and one which laid down the basic body plan which most complex animals, including humans, would eventually inherit.

The inconspicuous animal resided in the ancient seas of Earth, likely crawling along the seafloor. This was the last common ancestor of bilaterians, a vast supergroup of animals including vertebrates (fish, amphibians, reptiles, birds, and mammals), and invertebrates (insects, arthropods, mollusks, worms, echinoderms, and many more).

To this day, more than 7,000 groups of genes can be traced back to the last common ancestor of bilaterians, according to a study of 20 different bilaterian species including humans, sharks, mayflies, centipedes, and octopuses. The findings were made by researchers at the Centre for Genomic Regulation (CRG) in Barcelona and were recently published in the journal Nature Ecology and Evolution.

Gene Evolution and Specialization

Remarkably, the study found that around half of these ancestral genes have since been repurposed by animals for use in specific parts of the body, particularly in the brain and reproductive tissues. The findings are surprising because ancient, conserved genes usually have fundamental, important jobs that are needed in many parts of the body.

When the researchers took a closer look, they found a series of serendipitous ‘copy-paste’ errors during bilaterian evolution were to blame. For example, there was a significant moment early in the history of vertebrates. A bunch of tissue-specific genes first appeared coinciding with two whole genome duplication events. Animals could keep one copy for fundamental functions, while the second copy could be used as raw material for evolutionary innovation. Events like these, at varying degrees of scale, occurred constantly throughout the bilaterian evolutionary tree.

“Our genes are like a vast library of recipes that can be cooked up differently to create or change tissues and organs. Imagine you end up with two copies of a recipe for paella by accident. You can keep and enjoy the original recipe while evolution tweaks the extra copy so that it makes risotto instead. Now imagine the entire recipe book is copied – twice – and the possibilities it opens for evolution. The legacy of these events, which took place hundreds of millions of years ago, lives on in most complex animals today,” explains Federica Mantica, author of the paper and researcher at the Centre for Genomic Regulation (CRG) in Barcelona.

Specialized Gene Functions Across Species

The authors of the study found many examples of new, tissue-specific functions made possible by the specialization of these ancestral genes. For example, the TESMIN and tomb genes, which originated from the same ancestor, ended up independently playing a specialized role in the testis both in vertebrates and insects. Their importance is highlighted by the fact that problems with these genes can disrupt sperm production, affecting fertility in both mice and fruit flies.

The specialization of ancestral genes also laid some foundations for the development of complex nervous systems. For example, in vertebrates, the researchers found genes critical for the formation of myelin sheaths around nerve cells, which are essential for fast nerve signal transmission. In humans, they also identified FGF17, which is thought to play an important role in maintaining cognitive functions into old age.

In insects, specific genes became specialized in muscles and in the epidermis for cuticle formation, contributing to their ability to fly. In the skin of octopuses, other genes became specialized to perceive light stimuli, contributing to their ability to change color, camouflage, and communicate with other octopuses.

By studying the evolution of species at the tissue level, the study demonstrates that changes in the way genes are used in different parts of the body have played a big role in creating new and unique features in animals. In other words, when genes start acting in specific tissues, it can lead to the development of new physical traits or abilities, which ultimately contributes to animal evolution.

“Our work makes us rethink the roles and functions that genes play. It shows us that genes that are crucial for survival and have been preserved through millions of years can also very easily acquire new functions in evolution. It reflects evolution’s balancing act between preserving vital roles and exploring new paths,” concludes ICREA Research Professor Manuel Irimia, co-author of the paper and researcher at the Centre for Genomic Regulation.

Reference: “Evolution of tissue-specific expression of ancestral genes across vertebrates and insects” by Federica Mantica, Luis P. Iñiguez, Yamile Marquez, Jon Permanyer, Antonio Torres-Mendez, Josefa Cruz, Xavier Franch-Marro, Frank Tulenko, Demian Burguera, Stephanie Bertrand, Toby Doyle, Marcela Nouzova, Peter D. Currie, Fernando G. Noriega, Hector Escriva, Maria Ina Arnone, Caroline B. Albertin, Karl R. Wotton, Isabel Almudi, David Martin and Manuel Irimia, 15 April 2024, Nature Ecology & Evolution.
DOI: 10.1038/s41559-024-02398-5

4 Comments on "Unveiling the Dawn of Complex Life: How a Simple Creature Set the Stage for Human Evolution"

  1. Zarthan South | April 29, 2024 at 6:04 am | Reply

    It always bothers me when I read about the evolutionary process as having some planned destination. “Animals could keep one copy for fundamental functions, while the second copy could be used as raw material for evolutionary innovation.” is but one. That isn’t how evolution works and it should never be presented as though creatures have any control over what ultimately happens. Every living thing is constantly being modified as their life goes on. Some of those modifications may be passed on through reproduction. Some are successful and some are not.

  2. Marcus marable | April 29, 2024 at 4:28 pm | Reply

    8 have noticed 8ñ the best interest in evolution and proper perspective and the redemption and to maintain mankind and the quality of life thereof is the ability to work together and Willings to attain actual kñowledge of what you understand to have accurate description to make accurate decision making proper proper perspective being the head and the bottom line to judge by to assure the lifeline of people places circumstances and situations that’s what will stand.

  3. Evolution has planned outcomes?
    This article reveals a religious perspective.

  4. Yes…. so our ancestors was insects….very interessting

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