While working with mice, Yale researchers used a process known as differentiation to successfully identify cells with certain types of receptors that could eventually morph into white adipocytes, the cells most people recognize as fat.
Yale School of Medicine researchers have answered a question millions regularly and plaintively ask themselves: Where did all that fat come from?
The research paper, published online on February 24 in the journal Nature Cell Biology, identifies specific cell types that eventually morph into white adipocytes — the cells most people recognize as fat.
“Now we can go back into the lab and ask how these cells are activated to actually make the fat,’ said co-author Matthew Rodeheffer, assistant professor of comparative medicine and molecular, cellular, and developmental biology, and a researcher at the Yale Stem Cell Center.
The increase of fat cells in obesity is particularly problematic because once established the cells are difficult to eliminate. However, surprisingly little is known about how fat cells first form. Rodeheffer and co-author Ryan Berry of Yale attacked the problem by isolating cells from fat and studying which cells could turn into fat cells, via a process known as differentiation. They successfully identified cells with certain types of receptors that could in fact become fat cells. The new study in mice confirmed that cells with these specific receptors on their surface are the precursors that create fat cells in the body.
Rodeheffer said it is now possible to study how these cells behave under different conditions, such as exercise, dieting, or overeating. The researchers hope to discover what causes the precursors to make new fat cells in obesity — and one day potentially block their creation.
“And that will keep us busy for the next 20 years,” he said.
Reference: “Characterization of the adipocyte cellular lineage in vivo” by Ryan Berry and Matthew S. Rodeheffer, 24 February 2013, Nature Cell Biology.
DOI: 10.1038/ncb2696
The study was funded by the National Institutes of Health.
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1 Comment
Please look at these MH drugs Risperidol/Risperidone, Secoel/Quietapine my spellings may not be correct, due to renaming and new patents etc.
These medicines are almost immediately causing fast build up of fat over lower abdomen. Even taking smallest amount to aid sleep can make you appear pregnant within 3 weeks.
This is a major indication of some action on fat cells in the body inducing fat appearance extremely quickly inducing immediate mobility problems in lower limbs.
Ie previously active people are becoming obese virtually overnight!
I know other side effects may also contribute ie heart rythmn deviation and palpatations and looking so out of shape quickly as well as impeded mobility caused by fat build up which prevents the legs from having a full range of movement wont help enable you to exercise whilst taking these medications.
There is definately a link with these medicines and a fast build up of fat cells over lower abdomen ie immediately above legs.
Who takes these medicines, people who are usually finding life harder than the rest of us ue BAME, disabled, and handicapped members of our society are being treated with these medicines in a higher proportion in our communities and this is not right.
Also people trying to find solutions to drug and or alcohol dependancy are being offered them.
Also females of roughly menapausal age whether actually peri-menapausal tested and confirmed. These pills are giving women who are healthy and physically thriving, all sorts if health worries which may be attributed to the menapause when they are suffering from the side effects of these pills. Heart rythmn problems, hot flushes, diabetese linked problems ie blood sugar level maintenance problems, brain fog, being irratible, when previously calm in nature and confusion. These medicines appear to offer no benefit to anyone.
Except they may offer you some link to the mitochondrian link to excessive fat cells.
Please at least look at the make-up of these medicines.
The people taking them don’t have a voice.😇