In a pioneering study, researchers from Harvard Medical School, University of Maine, and MIT have introduced a chemical method for reversing cellular aging. This revolutionary approach offers a potential alternative to gene therapy for age reversal. The findings could transform treatments for age-related diseases, enhance regenerative medicine, and potentially lead to whole-body rejuvenation.
Groundbreaking Discovery in Aging Reversal
In a monumental study, a team of researchers has revealed a novel approach to combating aging and age-related diseases. This work, undertaken by scientists at Harvard Medical School, introduces the first chemical method to rejuvenate cells, bringing them to a more youthful state. Prior to this, only powerful gene therapy could achieve this feat.
On July 12, 2023, researchers from Harvard Medical School, the University of Maine, and the Massachusetts Institute of Technology (MIT) published a fresh research paper in Aging. The paper, titled, “Chemically induced reprogramming to reverse cellular aging,” extends upon a previously groundbreaking discovery. The researchers are Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev, and David A. Sinclair.
Exploring the Methodology
This discovery builds on the finding that the expression of specific genes, known as Yamanaka factors, can transform adult cells into induced pluripotent stem cells (iPSCs). This breakthrough, which earned a Nobel Prize, prompted scientists to question if cellular aging could be reversed without pushing cells to become too young and potentially cancerous.
In this recent study, the scientists probed for molecules that could, in tandem, revert cellular aging and refresh human cells. They designed advanced cell-based assays to differentiate between young and old, as well as senescent cells. The team employed transcription-based aging clocks and a real-time nucleocytoplasmic protein compartmentalization (NCC) assay. In a significant development, they identified six chemical combinations that could return NCC and genome-wide transcript profiles to youthful states, reversing transcriptomic age in less than a week.
Relevance and Potential Applications
The Harvard team has previously shown the possibility of reversing cellular aging without causing unregulated cell growth. This was done by inserting specific Yamanaka genes into cells using a viral vector. Studies on various tissues and organs like the optic nerve, brain, kidney, and muscle have yielded encouraging results, including improved vision and extended lifespan in mice. Additionally, recent reports have documented improved vision in monkeys.
These findings have profound implications, paving the way for regenerative medicine and potentially full-body rejuvenation. By establishing a chemical alternative to gene therapy for age reversal, this research could potentially transform the treatment of aging, injuries, and age-related diseases. The approach also suggests the possibility of lower development costs and shorter timelines. Following successful results in reversing blindness in monkeys in April 2023, plans for human clinical trials using the lab’s age reversal gene therapy are currently underway.
Views from the Research Team
“Until recently, the best we could do was slow aging. New discoveries suggest we can now reverse it,” said David A. Sinclair, A.O., Ph.D., Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and lead scientist on the project. “This process has previously required gene therapy, limiting its widespread use.”
The team at Harvard envisions a future where age-related diseases can be effectively treated, injuries can be repaired more efficiently, and the dream of whole-body rejuvenation becomes a reality. “This new discovery offers the potential to reverse aging with a single pill, with applications ranging from improving eyesight to effectively treating numerous age-related diseases,” Sinclair said.
Reference: “Chemically induced reprogramming to reverse cellular aging” by Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev and David A. Sinclair, 12 July 2023, Aging-US.
DOI: 10.18632/aging.204896
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58 Comments
How long would it be possible to be available to public consumption?
I see no answer to Marsife’s question.
How can I get some
Eat babies
Since the US FDA barely recognizes aging as a “disease”, they would be the main hindrance, even in getting a permission as a “investigational new drug!” for these molecules. If that approval happens, we are probably looking at a 3-5 years’ horizon.
“If living was a thing that money could buy, then the rich would live and the poor would die.”
Shut up.
My mother was reading articles like this when she was young. I’ve been reading them all my life. My grandkids will also be reading them.
YEP. Promises! Promises! All the way back to the Egyptian Pharaohs and their “cost-intensive” bid for immortality.
If one skips the fancy Jar and storage in a Mausoleum, it “more affordable”.
It certainly won’t matter to the Dead. As such, memory and some photos will do.
Lol, not very optimistic eh? Well they never had regenerative medicine in terms of like stem cell therapy and AI. I think you might be surprised on this one. It just might be your generation that sees it.
Except now we are actually able to engineer the genome. Look at myostatin knockout animals for an example. I think the Chinese weightlifters have used this myostatin knockout at the last two Olympics to shatter all the world records. They call it ‘double-muscle’ which is apt, since one of their weightlifters broke the world record standing on one leg….
“The Father of Genetic Engineering” George Church has labelled himself a GMO. There were a bunch of genetically modified children created by Dr. He in China, most famously the twins Lulu and Nana, whose CCR5 knockout is correlated to higher intelligence.
There’s “The Canadian Epstein” Peter Nygard who cloned himself then used the cloned fetuses to rejuvenate himself.
You can go to the Thermofisher Scientific website, use their AI tool to create custom human genetic inserts, generate a list of ingredients and instructions, add to cart and have them all sent to your door.
A basic genetic engineering set costs less than a new car. Josiah Zayner’s ODIN sells basic kits for much cheaper than that, and has run several genetic engineering experiments on himself.
Just because an ancient Greek couldn’t go to the moon doesn’t mean it’ll never happen. What an absurdly parochial view when half the world just had a gene therapy injected in to them.
Is David Sinclair involved? Then, it’s very probably more snake oil.
Disagree completely. Sinclair is a MAJOR brain and a great hope!
If science is able to eliminate death control via senescence and apoptosis, and this technology spreads to everyone regardless of affordability, then birth control will become even more critical, in fact essential, to keep the human race from overpopulating into mass disaster. But it would also mean the end of natural human evolution, and the advent of taking our evolution into our own hands via genetic modification, because it would also mean the end of children, who are evolution’s natural mutation-testing petri dish, in the name of preserving terrestrial space for the survival of the glut of already living and henceforth virtually immortal adults.
We will not be threatened by overpopulation. Man is not that stupid.
This idea tires me. It falls in line with UFO and the Pyramids. Waste of time and emotion.
Live life well and properly instead; doing your best to be loving kind to all. Peace.
They have literally already done it with mice.
People will probably mass produce less but they are working on taller buildings and colonizing the moons. The tech is there.
1. Reversing methylation doesn’t cure aging. Even if we can control senescent cells, extend telomeres, restore healthy mitochondria, and restore the thymus gland. None of the aging scientists have a plan for repairing DNA errors. We incur 10,000 to 100,000 DNA breaks in each cell every day. 99%+ are repaired correctly, but some are not. Those mistakes carry over to future cell generations. Most DNA is junk, other genes are not important to the tissue damaged, so every mistake is not crucial. There are genetic variants that do a better job of repair and are more represented in the population of centenarians. And there are other things that accumulate like glucosepane, forms of amyloid plaques like misfolded transthyretin, genetically damaged mitochondria (they burn fuel inefficiently making wastes like lipofuscin which is the brown stuff in age spots, and these lipofuscin accumulations are not just on the skin. They are in muscle, heart, liver, kidneys, and the brain). We accumulate scar tissue. Accumulated latent infections often promote diseases, quite possibly schizophrenia, Alzheimer’s, and others.
2. The Earth can handle 500x current human population provided we develop technology to directly manufacture food from atoms, recycle everything, live in greater density, and in more diverse locations, like under domes in Antarctica, on the oceans, underground, on stilts above the surface of the land, without interfering with the land. And we can build large space stations and inhabit the Moon, Mars, asteroids… The Solar System can support many trillions of humans while dramatically improving the Earth environment.
3. Machines and tech that allow food surplus and some tech like contact lenses and braces, limit selection pressure, but it remains. We can and should reduce genetic birth defects through genetic surgery at the zygote or blastocyst stage. But there will always be natural births that are not repaired. We can fix some of this, but the repairs will be limited.
Thanks for being a skeptic (who demands to be convinced) and not a cynic (who CANNOT be convinced!). I broadly agree with your views.
Yes I immediately went to thinking along the same lines that you did. Where we put everybody? I imagine just like anything when it becomes valuable and more scarce, it becomes a commodity. I could see poor people selling their credits that allow them to reproduce in exchange for enough money to live comfortably. There would be all kinds of moral implications, of course.
Evolution is inefficient. Genetic manipulation to improve our genomes is possible now. A geneticist in China designed twin babies for a couple to their specifications! Born and healthy. Directed and rapid , effective evolution will make mankind better!
Deaths will still happen (accidents) and births will be carefully arranged to fit carrying capacity of the planet based on our technology at the time. Sam Altman’s group ( of OpenAI ) is working aggressively on nuclear fusion as an unlimited energy source.
Moving towards a better world, with no birth defects that parents have to deal with for a lifetime!
The future is bright ! ( if we don’t stupidly nuke ourselves)
Well said. Doubters need to do the work to understand instead of dismissing this offhand. These researcher have found a real process and many well funded groups are rapidly developing techniques to rejuvenate organs and even whole body rejuvenation.
Let me die, and let it die! Mankind is fooling with God and should take heed! The Kingdom of Heaven is at hand!
Were we playing God, when we developed fire? Clothing? Shoes? The plow? Antibiotics? Anesthesia? Eyeglasses? Scuba gear? Airplanes? Spaceships?
If you haven’t noticed, life expectancy has tripled from the time of the Romans. If it doubles or triples again, how is that any different? I am not saying this treatment will double it. I would find that highly unlikely, but in combination with other advances, it is not inconceivable.
It is very unlikely you will be kept alive, if you sign a do not resuscitate will, and have a copy in your wallet, or on a metal wristband. Certainly, no one will force you to take some elixir of life or anything like that. Seems exceedingly unlikely, anyway.
Telomeres Telomeres Telomeres
If you don’t understand what telomeres are and do don’t say a word.
How does one sign up for the clinical trials?
I would do the clinical trial as well!
I am 82 years old and have hypertension and several other age related diseases. I would to take an antiaging compound like in the Harvard study hopefully to move me back to a healthy 20 year old.
How can you try this?
This would be extremely dangerous to try. It may be justified for some very important tissue like the retina to restore vision or the “hair” cells in the cochlea to restore stop maddening ear ringing, or to attempt to reverse spinal injuries.
For whole body, there are many steps to go to insure safety. They have to test on normal mice, perhaps dogs, then monkeys, then people with some unusual condition where methylation aging is accelerated, then probably the very old, with little to lose. Probably with a very modest dose, at first. Probably a good 15 years, before they get to ordinary 40-70-year-olds. Maybe millionaires will get it in some Latin American country in 5 or 10 years. But that would be very risky. I would try gene therapy, way before I would try this.
Human studies start next year at Life Biosciences. They have done all the other already. Doing treatment of eye diseases ( glaucoma). After that, rejuvenation work will begin. Sam Altman’s group ( Retro Biosciences) also developing this approach ver aggressively.
Check it out. AI is supercharging all science!
I’m open for a clinical trial. 58 yr old healthy male. Sign me up!
I’m really hoping that there will be side effects like growing my long blonde hair back. If I may die during this process let me die with my boots on! And a full head of hair!
I am with you on this Troy!
There have been other successful attempts to correct fast aging mice. The type of fast aging mice are well-chosen, or engineered exactly for the test. Something of a parlor trick. But it has a purpose. It verifies what has gone wrong and that it can be fixed. But it gives the impression that you can just apply this to people with decent chance of success.
Unless and until they dramatically increase the life expectancy of normal mice, they have not proven anything. That takes a few years. Hopefully, they already started a couple of years ago because doing something dramatic, like doubling average lifespan, will take 5 or 6 years to finish.
There are many things which change during aging. This will not correct the other dozen, even if it worked perfectly in humans with no side effects. And that is a big “if” because it may restore senescent cells, which can be very dangerous. There is also the risk that cells will regress too far and forget what they are and create tumors.
If you talk to aging scientists, they will likely emphasize the aspect of aging they are working on, and mostly ignore the others. Methylation may be upstream of some of these, but not all of them. Various types of accumulations with age are unlikely to be addressed. Things like the accumulation of genetic damage. Each cell’s DNA is broken 10,000-100,000 times a day. And most of the time correctly repaired, but not all the time. Errors are carried over to the next generation of cells. And there is this stuff called Glucosepane which accumulates between cells making the tissues stiff, especially arteries, and is implicated in a number of aging diseases. Neither our bodies nor scientists have figured out how to reverse this. There are also the accumulations of misfolded proteins called amyloid. And there are 30 kinds, not just the 1 involved in Alzheimer’s, like Wild-type ATTR Amyloidosis, which may be near certain over 110 years of age. That stiffens the heart, and make exertion very difficult.
Read the research. The epigenome is what is predominately damaged by environmental insult and that is what that epigenetic reprograming corrects even in CNS neurons. DNA is rarely damaged in comparison with the epigenome. Reprograming does work. It would correct much of the damage we call aging. Other techniques are being investigated for what is not corrected by reprograming.
Correct!
Sounds like you won’t be open to the possibility regardless! BUT time will tell for the rest of us!
Just realize that if epigenetic reprograming adds 20 years to some people’s lifespan then those people live to see further advances in the science and further extensions of lifespan. They also continue to gather more experiences and contribute their experience to society. Those who don’t simply disappear!
Clickbait goodness
How much reverse aging are we talking about? The paper as I understand it spoke of age reversal of only a few years. Also how long will this “pill” remain in effect? Will there be a rebound or is the effect permanent? Much remains to be done but still a groundbreaking paper even if the results don’t lead to an anti-aging pill.
Willing to take part of the human trials. Soon to be 62 &
Marine vet!
At 94 and in good health and determined to live beyond 100+, what specifics should I consider beyond a careful diet, three one hour days weakly at the gym, routine shopping and Church on Sunday.
Broad-spectrum prayers
Thirty-nine guards out there – start now
I say,..we’ll see. Mother Nature is not one to be messed with.
Mother nature is messed with all the time. Vaccines, surgeries, pills, etc…
Correct!!
Mother nature provided each of us with a brain. Our brains gives us the power to learn, to think and to create. I we were not destined to use our brains to benefit our species, why would we have been given brains?
Still collect social security?
Always it’s the mice that get the first shot at it. How about human trials for those of us with little to loose? Old age is the pits. Once hearing is gone, eyesight starts to fade and dementia begins to slow brain functions, there’s not much quality of life left. I’d rather take a chance on restoring full function for a few years than slowly fade into uselessness. Even if it doesn’t work, at least I’d contribute some data to the research community.
By a small Chance I would like to Volunteer for your study. This has been a Thought throughout my life to stay young looking while we age. I’m Preserving my body (Cryonics) for the further to bring myself
back to my 20s.
To those who say we can’t or shouldn’t try to slow or reverse the biological aging process I say … Fine, then don’t participate. To others who wish to contribute to society, to preserve and use the lifetime of knowledge they’ve accumulated, the skills they’ve learned and to pass that irreplaceable wisdom on to younger generations, I say join the human race and try to make it better. Death is a complete and terrible waste of everything we learn throughout our lives. Everything others took the time and effort to teach us and everything we’ve learned from our own experiences. The longer we live, the wiser we become. The longer we live, the more we can contribute to the sum of human knowledge. As one who has attended the university of life for almost 80 years, I feel that I have useful knowledge and skills which should be passed on. Deteriorating sight and hearing are obstructing my ability to teach or conduct research. Unless I can participate in age reversal testing and restore my physical abilities, I will eventually become a burden on society and negate whatever useful contributions I’ve made in the past. Give me the opportunity to participate in developing health and vitality restoration therapies. If successful, I can continue to contribute. If I die in the attempt, my body and whatever can be learned from a study of it, will contribute to future research. Either outcome will contribute useful knowledge to the human race.
You need to fix the mitochondria which have been poisoned to death over the last 80 years. And you will have to preserve your telomeres. When cancer has been solved then I think the technology will be available to fix such minor problems
Read the research. The epigenome is what is predominately damaged by environmental insult and that is what that epigenetic reprograming corrects even in CNS neurons. DNA is rarely damaged in comparison with the epigenome. Reprograming does work. It would correct much of the damage we call aging. Other techniques are being investigated for what is not corrected by reprograming.
well said!
Amen Brother!
Of the many stages of life delineated in the ancient Buddhist Sutras,”Old Age & Death” are merged into one’! While it’s interesting to learn another of the myrriad proximal causes the end of of life, there,’s always a novel one to to set my 86-year old self up straight: “Wild-type ATTR Amyloidosis, which may be near certain over 110 years of age. That stiffens the heart, and makes exertion very difficult.” In fact, We’re all going to be killed by statistics! All Men are Mortal is a mathematically certain truth about the (empirical) world!
I’m relying on Elysium: “I’m gonna ride [my horse] ’till I can’t no more!” (Old Town Road)
For pros this is good news for the older ones who want to be look younger and I think for this study, older people will now have a good health as younger ones, and they will have a better immune system and body system. By addressing the underlying causes of aging, this method could significantly improve the quality of life for older individuals. And the study said it will be more accessible for those people who want it benefiting the older ones. And this is good for older ones who have a bone problem and the one who get easily injury because this study can treat regenerating issue and can cure age-related issue and conditions. And it is great news to this aging reverse will be long -term, and it will not cost yearly. For cons: This might a potential risk and this study is still not proven and tested, and this study is still in its early stage and more research of this are needed. And for the long-term effect of this might have an unseen side effect like you may not know that there is already side effect in your body or health issue. And in every research like this there is might consequences and risk for this and once you do this it cannot take back to your original body etc. And for lifespan for the people who want it there is might potentially risk you it might short your life span or long we didn’t know. And in this research, they don’t have a human clinical trial which mean this not proven, human clinical are still in progress and only limited.
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