Anthrax may soon help more people win the fight against bladder cancer, which the Centers for Disease Control and Prevention says strikes about 72,000 Americans each year and kills about 16,000, and is one of the most expensive cancers to treat.
The current treatments for bladder cancer are invasive for patients — who often must sit for hours at a time with a bladder full of an agent designed to kill cancer cells and tumors. Bladder cancer also is one of the most reoccurring for people diagnosed with the disease.
“We have seen outstanding results with our treatment. It is fast and effective, both of which are critical for people dealing with this devastating disease.” — R. Claudio Aguilar
Now, researchers at Purdue University have come up with a way to combine the anthrax toxin with a growth factor to kill bladder cancer cells and tumors. The research is published in the October 4 edition of the International Journal of Cancer.
“We have effectively come up with a promising method to kill the cancer cells without harming the normal cells in the bladder,” said R. Claudio Aguilar, an associate professor and the assistant head of biological sciences in Purdue’s College of Science. “It is basically like creating a special solution that targets cancer cells while leaving healthy cells alone.”
Aguilar said the bladder has its own protective layer, which saves the good cells from the anthrax mixture but offers no protection for the cancer cells and tumors. He said the Purdue system works within minutes — instead of the usual hours for bladder cancer treatment — to target the cancer cells in the bladder.
“We have seen outstanding results with our treatment,” said Aguilar, who works as part of a team focused on cell identity and signaling at the Purdue University Center for Cancer Research. “It is fast and effective, both of which are critical for people dealing with this devastating disease.”
Aguilar and his group worked with the Purdue teams led by Timothy Ratliff and Deborah Knapp to test their solution in dogs with bladder cancer who had run out of other treatment options. They found this new agent decreased the tumor size without causing any other side effects in the animals.
The Purdue team thinks a similar treatment may help people and animals with other cancers, including those affecting the lungs or skin.
Reference: “A novel, safe, fast and efficient treatment for Her2‐positive and negative bladder cancer utilizing an EGF‐anthrax toxin chimera” by Sherwin Jack, Kayalvizhi Madhivanan, Swetha Ramadesikan, Sneha Subramanian, Daniel F. Edwards II, Bennett D. Elzey, Deepika Dhawan, Andrew McCluskey, Erin M. Kischuk, Alexander R. Loftis, Nicholas Truex, Michael Santos, Mike Lu, Amy Rabideau, Bradley Pentelute, John Collier, Hristos Kaimakliotis, Michael Koch, Timothy L. Ratliff, Deborah W. Knapp and Ruben C. Aguilar, 4 October 2019, International Journal of Cancer.
The researchers also worked with partners in the Indiana University School of Medicine, the Massachusetts Institute of Technology, and Harvard University.
Aguilar and the other researchers worked with the Purdue Research Foundation Office of Technology Commercialization to patent the new treatments.