Schematic illustration depicting nanopore cooling by charge-selective ion transport. Credit: 2023 Tsutsui et al., Peltier cooling for thermal management in nanofluidic devices, Device, edited
A groundbreaking study by Japanese researchers demonstrates cooling via a nanopore, revolutionizing temperature control in microfluidic systems and enhancing understanding of cellular ion channels.
Have you ever wondered how water boils in an electric kettle? Most people may think electricity simply heats up the metal coil inside the kettle, which then transfers the heat to the water. But electricity can do more than that. Heat can be generated when electricity makes ions in solution flow. When all the ions and surrounding molecules can move freely, this heating effect is evened out across the whole solution. Now researchers from Japan have investigated what happens when this flow is blocked in one direction.
Cooling Through Nanopore Technology
In a study recently published in Device, the team led by researchers from SANKEN (The Institute of Scientific and Industrial Research), Osaka University has shown that it is possible to achieve cooling by using a nanopore—a very small hole in a membrane—as a gateway that only allows certain ions through.
In general, using electricity to drive ions in solutions draws positively charged ions and negatively charged ions in opposite directions. So, the heat energy carried by the ions travels both ways.
Understanding Ionic Flow and Temperature Control
If the path of the ions is obstructed by a membrane with only a nanopore to get through, then it becomes possible to control the flow. For example, if the pore surface is negatively charged, then the negative ions can interact with it rather than pass through, and only the positive ions will flow, taking their energy with them.
“At high ion concentrations we measured an increase in temperature as the electrical power was increased,” explains study lead author Makusu Tsutsui. “However, at low concentrations the available negative ions interacted with the negatively charged nanopore wall. Therefore, only positively charged ions passed through the nanopore, and a decrease in temperature was observed.”
Applications in Microfluidics and Cellular Biology
The ionic refrigeration that was demonstrated could be used for cooling in microfluidic systems—setups that are used to move, mix, or investigate very small volumes of liquids. Such systems are important across many disciplines from microelectronics to nanomedicine.
In addition, the findings could help further the understanding of ion channels, which play crucial roles in the finely balanced machinery of cells. Such insight could be key to understanding function and disease, as well as designing treatments.
Broader Implications and Future Prospects
“We are excited by the breadth of the potential impact of our findings,” says study senior author Tomoji Kawai. “There is considerable scope for the nanopore material to be tailored to tune the cooling. In addition, arrays of nanopores could be created to amplify the effect.”
The list of areas that could be enhanced by the findings is indeed considerable and extends to using a temperature gradient to generate electric potential. This could be applied for temperature sensing or in blue energy harvesting.
Reference: “Peltier cooling for thermal management in nanofluidic devices” by Makusu Tsutsui, Kazumichi Yokota, Wei Lun Hsu, Denis Garoli, Hirofumi Daiguji and Tomoji Kawai, 5 December 2023, Device.
DOI: 10.1016/j.device.2023.100188
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