Men with longer CAG repeats in the androgen receptor gene are more likely to suffer severe COVID-19, suggesting a genetic biomarker that could help predict ICU admissions and inform new therapies.
Researchers have discovered a novel biomarker to identify male COVID-19 patients most at risk for ICU admission. The findings presented today at EADV’s 2021 Spring Symposium, suggest that men with genetic characteristics (phenotypes) sensitive to the male sex hormone androgen, are more likely to experience severe COVID-19 disease.
Researchers were driven to study the association between the androgen receptor (AR) gene and COVID-19, after observing the disproportionate number of men hospitalized with COVID-19 presenting with androgenetic alopecia (a common form of hair-loss) compared to the expected number in a similar age-matched population (79% vs. 31-53%).
AR Gene and CAG Repeat Length
Androgenetic alopecia is known to be controlled by variations in the AR gene, which affects how sensitive the body is to androgens (hormones such as testosterone). In addition, an enzyme implicated in COVID-19 infection (TMPRSS2) is regulated by an androgen response element – meaning that it too may be affected by variations in the AR gene. As the polyglutamine repeat (CAG repeat) region located in the AR gene is associated with both androgen sensitivity and androgenetic alopecia; this research sought to identify the connection between CAG repeat region length and predisposition to increased COVID disease severity.
A prospective study of 65 hospitalized COVID-19 positive men measured the AR CAG repeat length of each man. Researchers found that male COVID patients with a CAG repeat below 22 nucleotides (CAG<22) were significantly less likely to be admitted into ICU than patients with a CAG count over or equal to 22 nucleotides (CAG≥22; p=0.05).
Androgen Receptors as a Biomarker for Severity
Dr. Andy Goren, Chief Medical Officer, Applied Biology, Inc., Irvine, California, USA, explains: “Our data show that longer AR CAG scores are associated with more severe COVID-19 disease and indicate that AR CAG repeat length could be used as a biomarker to help identify male COVID-19 patients most at risk for ICU admissions.”
He continues, “The identification of a biomarker connected with the androgen receptor is another piece of evidence highlighting the important role of androgens in COVID-19 disease severity.”
Further research conducted by Dr. Andy Goren and his team, reported at the EADV Spring Symposium, explores a promising new therapy for COVID-19 using a novel androgen receptor antagonist to regulate TMPRSS2 expression and possibly treat COVID-19 patients. The results of this study were submitted for publication in a peer-reviewed journal.
“This research demonstrates the scientific value of dermatology by offering key insights into the role of genetics and its link to COVID disease. It is an excellent example of some of the pioneering abstracts being showcased at The EADV Spring Symposium this year,” says Prof. Lidia Rudnicka, EADV Board Member and Professor at the Medical University of Warsaw.
Meeting: EADV Spring Symposium 2021
Never miss a breakthrough: Join the SciTechDaily newsletter.
Follow us on Google and Google News.