Postbiotics – The Latest Breakthrough in Gut Health

Human Gut Microbiome Illustration

Postbiotics help to shift our gut microbiome towards a healthy composition.

Joining prebiotics and probiotics is the latest advancement in gut health, known as “postbiotics”. Here is what they are, and why they are important. 

When it comes to our health, many of us are familiar with prebiotics and probiotics, along with their significant advantages for our digestive health, even if distinguishing between them can be challenging. But what about postbiotics?

For a brief overview, probiotics are living microorganisms, often referred to as ‘good bacteria’, that we ingest through our food to foster a healthy gut microbiota – the vast collection of trillions of bacteria typically residing in our intestines.

Probiotics such as Lactobacillus and Bifidobacterium, also known as lactic acid bacteria, are found in fermented foods including yogurt, sauerkraut, some cheeses, and certain fermented beverages, as well as dietary supplements.

Prebiotics are what the probiotics feed on, primarily the undigestible plant materials in our diet including fibers that only can be used by the probiotics and gut microbiota.

Fruits including bananas and apples, vegetables such as Jerusalem artichokes, leek and asparagus, onions, garlic, and also certain cereals, nuts, and legumes are rich in prebiotic compounds.

Certain combinations of probiotics and prebiotics can be used together to boost the beneficial effects of probiotics when consumed, and these are known as synbiotics.

So what are postbiotics?

As their name may suggest, postbiotics are what are generated after the digestion of certain foods. They are the breakdown products or ‘metabolites’ following the digestion of prebiotics and fiber-rich compounds by probiotics and our gut’s resident microbiota.

The colon, the lower part of our digestive system is where many postbiotics are produced, as the microbiota and food we eat go through a phase called colonic fermentation in the colon.

One of the important things that happen during colonic fermentation is the breakdown of non-digestible prebiotic and fiber substances in our diet by gut microbiota. This produces beneficial compounds for our health like short-chain fatty acids, certain vitamins (Vitamin B and K), amino acids, and antimicrobial peptides that prevent the growth and activities of harmful bacteria.

Even some carbohydrate substrates known as secreted polysaccharides and exopolysaccharides produced by these bacteria provide various beneficial effects, and so are considered postbiotics.

But because the concept of postbiotics is relatively new, the process of defining them is still a work in progress. In our article Nature Reviews Gastroenterology & Hepatology, we discuss the definition of probiotics and their importance in enabling consumers to understand which products have health-promoting properties.

Benefits of postbiotics

Generally, postbiotics can provide us with similar benefits to that of probiotics and prebiotics.

But the beauty of postbiotics is they can provide these benefits even without any side effects that probiotics and prebiotics may have. For example, some people might experience discomfort because of a temporary increase in gas and bloating after intake of probiotics and prebiotics.

So you can take postbiotics as supplements if you cannot tolerate them or you do not like consuming probiotics and prebiotics.

One of the well-known benefits of postbiotics is their ability to shift our gut microbiome toward a healthy composition. Research has shown that beneficial postbiotic compounds can support the growth, activities, and functions of probiotics and gut microbiota.

It is more like a boosting effect, so that our gut microbiota, which plays a crucial role in our overall health, can fight against pathogenic microorganisms like Salmonella in our body. As we know healthy gut microbiota keep us healthy as they can positively influence our overall health.

Postbiotics can also stimulate our immune system as well. For example, exopolysaccharides produced by Lactobacillus delbrueckii ssp. bulgaricus, one of the starter culture bacteria used to produce yogurt, have the ability to enhance the activity of the body’s natural killer cells.

Similar positive effects on the immune system were shown in a recent study where researchers used exopolysaccharides produced by Lactiplantibacillus plantarum isolated from human breast milk.

Postbiotic short-chain fatty acids produced by the digestion of fiber-rich plant foods can also lower the risk of colon cancer. They are considered cancer-protective metabolites. Some positive effects of postbiotics on breast cancer patients have also been shown.

It is still early days for postbiotics research, with most of these studies being cellular-based lab experiments or performed on animals. However, their applications in humans are promising.

Are dead probiotics useful?

For beneficial probiotic effects, they must be live when consumed and travel through our gut. But recent research shows that even if you completely remove the probiotic cells from its growth medium, for example, the food source the probiotics are grown in, the cell-free source can still produce some positive effects including boosting the immune system.

This appears to be because some postbiotics produced by these probiotics when they are in food remain even if you remove all living probiotics. For example, some exopolysaccharides and vitamins remain active and do not degrade in the food before we consume them.

Some dead probiotics and their cell components have also been shown to provide beneficial effects. But much more research needs to be done in this area.

How to harness the benefits of postbiotics

As the field of probiotics is still growing, there will be a lot more to discover in the coming years.

For now, the best thing we can do for gut health is to consume probiotic-containing foods like yogurt and sauerkraut because they contain both the postbiotics that have been produced during processing and storage as well as the living probiotics, which will continue to release more postbiotics in the gut.

Including prebiotic-rich plant foods in the diet will then add to these health benefits, providing the food for probiotics as the first step towards a healthy gut microbiome.

Reference: “Postbiotics — when simplification fails to clarify” by José Eleazar Aguilar-Toalá, Stefania Arioli, Pradip Behare, Clara Belzer, Roberto Berni Canani, Jean-Marc Chatel, Enza D’Auria, Mônica Queiroz de Freitas, Eran Elinav, Erick Almeida Esmerino, Hugo S. García, Adriano Gomes da Cruz, Aarón F. González-Córdova, Simone Guglielmetti, Jonas de Toledo Guimarães, Adrián Hernández-Mendoza, Philippe Langella, Andrea M. Liceaga, Marciane Magnani, Rebeca Martin, Mohammad Tamrin Mohamad Lal, Diego Mora, Mehran Moradi, Lorenzo Morelli, Fabio Mosca, Filomena Nazzaro, Tatiana Colombo Pimentel, Chao Ran, Chaminda Senaka Ranadheera, Maria Rescigno, Azucena Salas, Anderson S. Sant’Ana, Katia Sivieri, Harry Sokol, Valentina Taverniti, Belinda Vallejo-Cordoba, Jaroslav Zelenka and Zhigang Zhou, 23 September 2021, Nature Reviews Gastroenterology & Hepatology.
DOI: 10.1038/s41575-021-00521-6

1 Comment on "Postbiotics – The Latest Breakthrough in Gut Health"

  1. I’ve taken pro and pre biotic supplements before and while I did get some benefit…..

    Changing my diet to eat more whole foods and vegetables, meat, and limiting fried foods make a much larger impact and I dont have to buy expensive man made supplements.

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