The research will enable the development of individualized, precision medicine for the management of inflammatory bowel disease in this underrepresented minority patient group.
According to a recent study from Case Western Reserve University and University Hospitals Cleveland Medical Center (UH), gay men are more than twice as likely as heterosexual males to develop inflammatory bowel disease (IBD) when both groups participate in high-risk sexual activity.
The study was recently published in the peer-reviewed medical journal Gut.
“To our knowledge, this is the first large population-based study that demonstrates a higher prevalence of IBD in men who engage in high-risk same-sex sexual activity,” said Emad Mansoor, study lead author and assistant professor at the Case Western Reserve School of Medicine and UH. “Our study is expected to open a new field of research into gastrointestinal inflammatory conditions.”
“Studying the cause of IBD in this underrepresented patient population in comparison to other patient groups,” said Fabio Cominelli, corresponding study author, professor at the School of Medicine, and chief scientific officer at UH, “will allow us to further investigate the cause of disease development in Crohn’s disease and ulcerative colitis patients and develop personalized precision medicine and treatment strategies, while also reducing stigma.”
The study’s importance is highlighted by the fact that, according to Gallup, more than 7.1% of Americans identify as LGBTQIA+, up from 5.6% in 2020.
Between 2002 and 2022, the researchers analyzed self-reported data from individuals treated at 58 healthcare organizations in the United States.
According to the data, 0.8% of individuals with a diagnosis of high-risk same-sex activity had Crohn’s disease, and 1.26% had ulcerative colitis. These results were contrasted with those of males who participate in high-risk heterosexual behavior, of whom 0.49% had Crohn’s disease and 0.52% had ulcerative colitis.
This study defined high-risk sexual activity as sexual contact without barrier protection as well as having several sexual partners.
The team also further analyzed the data in relation to Crohn’s disease and found men who engaged in high-risk same-sex sexual activity were more likely to have peri-anal disease including peri-anal abscess, rectal abscess, and stricturing disease of the colon or small intestine. Among those with severe manifestations of ulcerative colitis, men who engaged in high-risk same-sex sexual activity were more likely to undergo partial colectomy.
The findings will be further evaluated by the team–including an investigation into the potential role of the gut microbiome–during a long-term study that allows investigators to track participants over time.
Continuing research with NIH funding
The team will continue its research to better understand if and how LGBTQIA+ individuals are more susceptible to gastrointestinal disorders through funding awarded this year for the Cleveland Digestive Diseases Research Core Center (DDRCC).
The center recently received a $100,000 supplementary grant from the National Institutes of Health (NIH). It will allow the researchers to significantly expand the number of LGBTQIA+ patients included in the DDRCC’s biorepository core, which collects plasma, tissue and stool samples, and gut microbiome analyses.
“This supplementary grant is an addition to our $1 million NIH grant funding that is running from 2020 through 2025,” Cominelli said. “We are in the process of opening a new clinic dedicated to LGBTQ+ patients with the goal of improving access to healthcare. Our goal is to improve patient access and develop new therapies for gastrointestinal conditions.”
Reference: “Epidemiology of inflammatory bowel disease in men with high-risk homosexual activity” by Emad Mansoor, Scott A Martin, Abe Perez, Vu Quang Nguyen, Jeffry A Katz, Shubham Gupta and Fabio Cominelli, 1 September 2022, Gut.
Let’s see here: “men who engage in high-risk same-sex sexual activity”… Iow: promiscuity has bad effects & inserting things into places that are not meant for it brings about consequences…
Who knew? Nature, morality and health!
Who would have thought sticking stuff up your butt is not good for you!???
You can say anal sex instead of high-risk blabbety blah, we all know what you’re talking about!
For the homophobes… women get undesirable results from your nasty penises all the time, you’re nothing special breeder!
“Research” of, by, and for the homosexual community paid for by the normal community.
not rocket science, well um…
Gay men it seems, continue to get a bum rap. Poke things in a sewage lagoon and bad things often happen.
You were surprised!!!???!!??
The heterosexual community paid for a program that agreed with some common sense deductions.
Wow u people who left those nasty comments need to learn some tolerance. I hope ur not passing ur views on to ur kids. Love is love.
I feel very sorry for the children of those that have made nasty comments.
Maybe some will grow up to have a shallow mind set, while others could grow up being gay / lesbian themselves and too scared to come out and lead a very unhappy life.