Simple Test Predicts Dangerous Pregnancy Disorder That Kills Thousands

Pregnant Woman Close Up

Researchers have developed a simple, low-cost way to predict preeclampsia, a potentially deadly condition that kills 76,000 mothers and 500,000 babies every year.

Australian researchers have developed a way to predict the onset of a deadly pregnancy condition that kills 76,000 women and half a million babies each year, mostly in developing countries.

Researchers from Edith Cowan University in Perth Western Australia have developed a simple, low-cost way to predict preeclampsia, one of the leading causes of maternal-fetal mortality worldwide.

Preeclampsia can cause devastating complications for women and babies, including brain and liver injury in mothers and premature birth.

Survey gives early warning

ECU researchers assessed the health status of 593 pregnant Ghanaian women using the Suboptimal Health Questionnaire.

The Suboptimal Health Questionnaire was developed in 2009 by Professor Wei Wang from ECU’s School of Health and Medical Sciences. Combining scores for fatigue, heart health, digestion, immunity, and mental health, the questionnaire provides an overall ‘suboptimal health score’ that can help predict chronic diseases.

Enoch Anto

Enoch Anto. Credit: Edith Cowan University

Professor Wang’s Ph.D. candidate Enoch Anto found that 61 percent of women who scored high on the questionnaire went on to develop preeclampsia, compared with just 17 percent of women who scored low.

When these results were combined with blood tests that measured women’s calcium and magnesium levels, the researchers were able to accurately predict the development of preeclampsia in almost 80 percent of cases.

Mr. Anto said preeclampsia was very treatable once identified, so providing an early warning could save thousands of lives.

“In developing nations, preeclampsia is a leading cause of death for both mothers and babies. In Ghana, it’s responsible for 18 percent of maternal deaths,” Mr. Anto said.

“But it can be treated using medication that lowers blood pressure once diagnosed.

“Both blood tests for magnesium and calcium and the Suboptimal Health Questionnaire are inexpensive, making this ideally suited to the developing world where preeclampsia causes the most suffering.

Reference: “Integration of suboptimal health status evaluation as a criterion for prediction of preeclampsia is strongly recommended for healthcare management in pregnancy: a prospective cohort study in a Ghanaian population” by Enoch Odame Anto, Peter Roberts, David Coall, Cornelius Archer Turpin, Eric Adua, Youxin Wang and Wei Wang, 5 August 2019, EPMA Journal.
DOI: 10.1007/s13167-019-00183-0

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