Yale Research Shows Immune Cells Are an Ally, Not Enemy, in Battle Against Alzheimer’s

New research in the battle against Alzheimer’s shows that brain immune cells (called microglia) seem to protect the brain by keeping amyloid plaques corralled, and are not re responsible for inflammation and damage to surrounding brain cells as previously thought.

Beta-amyloid is a sticky protein that aggregates and forms small plaques in the brains of the elderly and is thought to be a cause of Alzheimer’s disease. Because specialized immune cells always surround these plaques, many have theorized that these cells are responsible for inflammation and damage to surrounding brain cells.

That theory appears to be wrong, according to a new study by Yale School of Medicine researchers published in the January 29 issue of Nature Communications. Instead of causing damage, these brain immune cells — called microglia — seem to protect the brain by keeping amyloid plaques corralled, the paper shows.

Previous research had shown that some people with large accumulations of plaques do not necessarily have symptoms of dementia, which led researchers to search for other causes of cognitive decline. Inflammation was one of the potential culprits identified by scientists. However, Alzheimer’s drugs that target inflammation in the brain have failed to show any benefit.

“The idea that inflammation is always bad is a simplistic view and is probably wrong when talking about Alzheimer’s,” said Jaime Grutzendler, associate professor in the Department of Neurology and senior author of the study. “In fact, as we age we lose microglia and become less able to confine plaques, leading to the release of plaque toxins that destroy the connections between neurons.”

The new study using high-resolution imaging technology revealed that in the brains of mice, microglia actually act as a physical barrier that slows the expansion of plaques and blocks the ability of free-floating beta-amyloid proteins to bind to the plaques and cause toxicity.

“One possibility is that microglia nicely insulate the rest of the brain from plaques and may explain why some people with them do not experience severe cognitive decline,” Grutzendler said. “By improving microglia’s shielding function, we were able to reduce toxicity to neurons.”

This insight could lead to new treatments for the disease, he added.

Carlo Condello and Peng Yuan of Yale are co-first authors of the paper. The research was funded by the National Institutes of Health.

Reference: “Microglia constitute a barrier that prevents neurotoxic protofibrillar ​Aβ42 hotspots around plaques” by Carlo Condello, Peng Yuan, Aaron Schain and Jaime Grutzendler, 29 January 2015, Nature Communications.
DOI: 10.1038/ncomms7176

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