Genetics News

New Genome-Wide Analysis Links Marijuana Dependence and Major Depression

March 30, 2016

7 Comments

New Study Links Genes to Marijuana Dependence and Major Depression

A newly published genome-wide analysis of more than 14,000 individuals has identified several gene variants that increase risk of cannabis dependence. The analysis also suggests that the genetic risk for dependence on marijuana is associated with a higher inherited risk of major depression. The new study is published in the journal JAMA Psychiatry. The study […]

Continue reading...

New Study Shows Neanderthals Boosted Our Immune System

January 7, 2016

0 Comments

New Research Shows Neanderthals Boosted Our Immune System

A new study from the Max Planck Institute reveals that the mixing of archaic human forms played an important role in shaping the immune system of modern humans. When modern humans met Neanderthals in Europe and the two species began interbreeding many thousands of years ago, the exchange left humans with gene variations that have […]

Continue reading...

Scientists Overcome Key CRISPR-Cas9 Genome Editing Hurdle

December 3, 2015

0 Comments

Researchers Develop a Highly Specific Genome-Editing Tool

Using structural knowledge of Cas9, scientists have overcome a key CRISPR-Cas9 genome editing hurdle and developed a highly specific genome-editing tool. Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have engineered changes to the revolutionary CRISPR-Cas9 genome editing system that significantly cut down on “off-target” […]

Continue reading...

Scientists Discover Genes for a Longer, Healthier Life

December 1, 2015

0 Comments

Researchers Discover Genes for a Longer Healthier Life

A team of scientists has discovered genes that are involved in physical aging. By influencing only one of these genes, the healthy lifespan of laboratory animals is extended – and possibly that of humans, too. Driven by the quest for eternal youth, humankind has spent centuries obsessed with the question of how it is exactly […]

Continue reading...

Genetically Reducing AMPK Activity May Prevent Hereditary Hearing Loss

November 9, 2015

0 Comments

New Genetic Modification May Prevent Hearing Loss

New research from Yale University reveals that genetically reducing AMPK activity delays hereditary hearing loss in mice. Hereditary hearing loss can worsen over time and lead to premature deafness. In a new study, a Yale-led research team successfully applied genetic modification to delay inherited hearing loss in mice. Led by professor of pathology and genetics […]

Continue reading...

New Epigenetic Algorithm Accurately Predicts Male Sexual Orientation

October 12, 2015

1 Comment

Epigenetic Algorithm Accurately Predicts Male Sexual Orientation

By using epigenetic information from just nine regions of the human genome, a new algorithm can predict the sexual orientation of males with up to 70 percent accuracy. “To our knowledge, this is the first example of a predictive model for sexual orientation based on molecular markers,” said Tuck C. Ngun, PhD, first author on […]

Continue reading...

Scientists Reveal Catalog of Human Genetic Variation

October 1, 2015

0 Comments

Researchers Reveal Catalog of Human Genetic Variation

Newly published research details the effects of human genetic variation, finding that each person possesses on average about 150 variants capable of disabling genes. A massive effort to study human genetic variation has ended with publication of two papers in the September 30 issue of the journal Nature that catalog the genomes of more than […]

Continue reading...

Bioengineers Develop a New System for Human Genome Editing

September 29, 2015

0 Comments

Scientists Develop a New System for Human Genome Editing

A team of scientists from MIT, Harvard and Wageningen University have developed a new system for human genome editing that has potential to increase the power and precision of DNA engineering. A team including the scientist who first harnessed the CRISPR-Cas9 system for mammalian genome editing has now identified a different CRISPR system with the […]

Continue reading...

B12 Identified as a Key Part of Photoreceptor Proteins

September 28, 2015

1 Comment

Scientists Identify and Map B12-dependent Photoreceptor

A team of scientists has discovered and mapped a light-sensing protein that uses vitamin B12 to perform key functions, including gene regulation. The result, derived from studying proteins from the bacterium Thermus thermophilus, involves at least two findings of broad interest. First, it expands our knowledge of the biological role of vitamin B12, which was […]

Continue reading...

Scientists Report a Major Breakthrough in Alzheimer’s Disease

September 20, 2015

0 Comments

Researchers Report a Major Breakthrough in Alzheimer's Disease

New research sheds light on a fundamental mechanism underlying the development of Alzheimer’s disease and could lead to new forms of therapy people with the disease. Alzheimer’s is the most common form of dementia globally and affects up to 40,000 people in Ireland today. It is the fourth leading cause of death in individuals over […]

Continue reading...

Harvard Researchers Explain the Reason for Genetic Obesity

August 25, 2015

0 Comments

Researchers Explain the Reason for Genetic Obesity

Researchers from Harvard Medical School and MIT reeval a genetic circuit that controls whether our bodies burn or store fat. Like many other conditions, obesity is caused by an interplay between genetic and environmental factors. While efforts to combat the obesity epidemic will need to include changes in diet and exercise, insights into the genes […]

Continue reading...

Researchers Discover Pathway That Controls Metabolism

August 20, 2015

0 Comments

Researchers Discover a Switch That Controls Metabolism

By analyzing the cellular circuitry underlying the strongest genetic association with obesity, a team of researchers from MIT and Harvard Medical School have unveiled a new pathway that controls human metabolism by prompting our adipocytes, or fat cells, to store fat or burn it away. Obesity is one of the biggest public health challenges of […]

Continue reading...

International Research Collaboration Reveals Mutations in DCHS1 Cause Mitral Valve Prolapse

August 19, 2015

0 Comments

Researchers Reveal Gene for Mitral Valve Prolapse

Researchers reveal that mutations of the DCHS1 gene cause a common form of mitral valve prolapse. An international research collaboration led by Harvard Medical School investigators at Massachusetts General Hospital has identified the first gene whose mutations cause the common form of mitral valve prolapse, a heart valve disorder that affects almost 2.5 percent of […]

Continue reading...

New Biosensors Turn Bacteria Into a Source of Natural Energy

August 13, 2015

0 Comments

Researchers Turn Engineered Bacteria into a Source of Natural Energy

New biosensors enable complex genetic reprogramming of common bacteria like E. coli. The process could be leveraged for sustainable biomanufacturing, using the metabolic processes of bacterial cells to generate valuable chemicals and fuels. Super-productive factories of the future could employ fleets of genetically engineered bacterial cells, such as common E. coli, to create valuable chemical […]

Continue reading...

Newly Developed Simple Protein Plays Active Role in Cellular Function

August 11, 2015

0 Comments

Yale Scientists Develope Simple New Proteins

Scientists from Yale University have created a synthetic protein that is active, despite its simplicity. Yale scientists have developed simple new proteins almost devoid of chemical diversity that still play a surprisingly active and specific role in cellular function, causing cells to act like cancer cells, they report August 10 in the Proceedings of the […]

Continue reading...

Yale Scientists Reveal ‘Major Player’ in Skin Cancer Genes

July 27, 2015

0 Comments

NF1 Identified as Major Player in Skin Caner Genes

Researchers from Yale University have confirmed that a gene known as NF1 is a “major player” in the development of skin cancer. A multidisciplinary team at Yale, led by Yale Cancer Center members, has defined a subgroup of genetic mutations that are present in a significant number of melanoma skin cancer cases. Their findings shed […]

Continue reading...

CCNE1 Gene Turns Back Cellular Clock

May 22, 2015

0 Comments

Researchers Discover Human-Specific Gene That Turns Back Cellular Clock

Yale researchers have discovered a gene that turns back the cellular clock, greatly aiding the reprogramming of mature cells. An exhaustive analysis of factors that allow mature cells to become like embryonic stem cells again has revealed a spliced form of a gene found only in primates that greatly aids the reprogramming of mature cells. […]

Continue reading...

Nanoparticles Deliver PNA Molecules to Correct Mutation in Cystic Fibrosis

April 28, 2015

0 Comments

Scientists Correct Mutation in Cystic Fibrosis

New research details how a team of scientists delivered peptide nucleic acids and donor DNA via microscopic nanoparticles to successfully corrected the most common mutation in the gene that causes cystic fibrosis. Cystic fibrosis is an inherited, life-threatening disorder that damages the lungs and digestive system. It is most commonly caused by a mutation in […]

Continue reading...