Harvard University News

Targeting Brain Metastases with Stem Cell Therapy

April 27, 2015

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Targeting Breast to Brain Metastatic Tumor

Researchers have developed an in vivo imageable breast-to-brain metastasis mouse model. Using real time in vivo imaging and subsequent composite fluorescence imaging, they show a widespread distribution of micro- and macro-metastasis in different stages of metastatic progression. Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General Hospital (MGH) have developed an “imageable” mouse model of […]

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Implantable Device Allows Doctors to Identify the Best Chemotherapy Agents

April 24, 2015

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Implantable Device Tests Cancer Drugs in Patients

A team of engineers has developed a new implantable device that will allow doctors to test the effectiveness of cancer drugs and to identify drugs that work best for each patient prior to starting systemic administration of chemotherapy. More than 100 drugs have been approved to treat cancer, but predicting which ones will help a […]

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New Study Helps Explain Increased Risk of Diabetes in Shift Workers

April 16, 2015

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New Research Helps Explain Increased Risk of Diabetes in Shift Workers

New research from Brigham and Women’s Hospital links blood sugar and the internal clock, and may help develop and improve strategies for controlling glucose levels in day-active people and night workers. A new study may help explain why glucose tolerance — the ability to regulate blood-sugar levels — is lower at dinner than at breakfast […]

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Researchers Identify a Vital Protein for Brain Development

March 16, 2015

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Researchers Identify a Vital Protein

Researchers from the Harvard Stem Cell Institute have identified a vital protein that can help determine embryonic development. A protein that is necessary for the formation of the vertebrate brain has been identified by researchers at the Harvard Stem Cell Institute (HSCI) and Boston Children’s Hospital, in collaboration with scientists from Oxford and Rio de […]

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New Research Shows How Early Human Ancestors Were Unique

March 10, 2015

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Researchers Show How Early Human Ancestors Were Unique

New research from Harvard University and colleagues from around the globe reveals that the teeth of early hominins grew unlike those of either modern humans or apes, suggesting that neither can serve as a useful proxy for estimating the age or developmental progression of juvenile fossils. For nearly a century, the debate has raged among […]

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Possible Signs of Progress in the Fight Against Parkinson’s

March 4, 2015

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Signs of Progress Against Parkinson’s

By using induced pluripotent stem cells, researchers have markedly reduced the symptoms Parkinson’s disease in primates. Harvard Stem Cell Institute (HSCI) researchers at University-affiliated McLean Hospital have taken what they describe as an important step toward using the implantation of stem cell-generated neurons as a treatment for Parkinson’s disease. Ole Isacson and colleagues reported that […]

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Study Shows Vitamin D Protects Against Colorectal Cancer

January 28, 2015

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Vitamin D Protects Against Colorectal Cancer

A newly published study from the Dana-Farber Cancer Institute reveals that vitamin D can protect some people with colorectal cancer by perking up the immune system’s vigilance against tumor cells. The research, published by the journal Gut, represents the first time that a link between vitamin D and the immune response to cancer has been […]

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Study Reveals Weight Training Targets Age-Related Abdominal Fat

January 5, 2015

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Study Shows Weight Training Targets Belly Fat

New research from the Harvard T.H. Chan School of Public Health shows that weight training helps target age-related abdominal fat in men. Healthy men who did 20 minutes of daily weight training had less increase in age-related abdominal fat than men who spent the same amount of time doing aerobic activities, according to a new […]

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Study Shows Digital Books Can Adversely Impact Overall Health

December 31, 2014

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E-Readers Foil Good Night’s Sleep

A newly published study from Harvard Medical School reveals that using light-emitting electronic devices before bedtime can adversely impact overall health. Use of a light-emitting electronic book (LE-eBook) in the hours before bedtime can adversely impact overall health, alertness and the circadian clock, which synchronizes the daily rhythm of sleep to external environmental time cues, […]

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New Method for Detecting Unwanted DNA Breaks in Human Cells

December 18, 2014

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New Method for Detecting Unwanted DNA Breaks

Researchers at the Harvard Medical School have developed a new method for detecting unwanted DNA breaks across the entire genome of human cells induced by the popular gene-editing tools called CRISPR-Cas RNA-guided nucleases. Members of the same team that first described these off-target effects in human cells describe their new platform, called GUIDE-seq (Genome-wide Unbiased […]

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Scientists Create the First 3D Maps of Entire Folded Genomes

December 15, 2014

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The First High-Resolution 3D Maps of Entire Folded Genomes

A team of researchers has created the first 3D maps of entire folded genomes, identifying approximately 10,000 folding loops in the human genome. In a triumph for cell biology, researchers have assembled the first high-resolution, 3-D maps of entire folded genomes and found a structural basis for gene regulation, a kind of “genomic origami” that […]

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A Pill to Shed Fat? Researchers Turn White Fat Cells Into Brown Fat Cells

December 10, 2014

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Researchers Turn White Fat Cells into Brown Fat Cells

Scientists from Harvard have created a system using human stem cells to screen for compounds that have the potential to turn white fat cells into brown fat cells. Harvard Stem Cell Institute (HSCI) researchers have taken what they describe as “the first step toward a pill that can replace the treadmill” for the control of […]

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Injectable, Spontaneously Assembling Vaccines Could Fight Cancer

December 9, 2014

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New Injectable 3D Vaccines Could Fight Cancer

A newly published study from the Wyss Institute and Harvard’s School of Engineering and Applied Sciences shows that programmable biomaterials can be delivered using needle injection to induce an immune response to fight cancer and infectious diseases. Cambridge, Massachusetts — One of the reasons cancer is so deadly is that it can evade attack from […]

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Researchers Uncover an Easily Detectable Precancerous State in Blood

December 4, 2014

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Researchers Uncovered a Detectable Precancerous State in Blood

Two newly published studies detail the discovery of a precancerous state found in blood, paving the way for research that focuses on detection and prevention of blood cancers. Researchers from the Broad Institute of MIT and Harvard, Harvard Medical School, the Harvard Stem Cell Institute (HSCI), and Harvard-affiliated hospitals have uncovered an easily detectable, “premalignant” […]

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Greater Adherence to the Mediterranean Diet Has Impact on Aging

December 4, 2014

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Mediterranean Diet has Impact on Aging

New research from Brigham and Women’s Hospital is the first study to link women, Mediterranean diet, and biomarkers of aging, revealing that greater adherence to the Mediterranean diet correlated with longer telomeres. The Mediterranean diet consistently has been linked with an array of health benefits, including decreased risk of chronic disease and cancer. Until now, […]

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The Rapid-Fire Evolution of Green Anoles

November 13, 2014

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Native Lizards Show Rapid Fire Evolution

A newly published study from Harvard University found that in just 20 generations in 15 years green anoles evolved larger toe pads equipped with more sticky scales to allow for better climbing. Though it’s often portrayed as a process that takes place over thousands of years, under the right circumstances the evolution of enhanced traits […]

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New Gene-Editing Technique Could Prove to be an Effective Technique for Blocking HIV

November 11, 2014

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Researchers Genetically Edit Human Blood Stem Cells

Using CRISPR Cas technology, researchers genetically ‘edit’ human blood stem cells to create what could prove to be an effective technique for blocking HIV. Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General (MGH) and Boston Children’s hospitals (BCH) for the first time have used a relatively new gene-editing technique to create what could prove […]

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