An Alzheimer’s-Proof Brain: Ground-Breaking Case Provides Clues to Treatment and Prevention of Dementia

Brain Energy Field

The researchers believe that the woman’s brain could provide important information about treating dementia.

A mutation known as APOE3 Christchurch appears to have protected the woman.

Due to a rare genetic mutation, Aliria Rosa Piedrahita de Villegas should have had Alzheimer’s disease in her 40s and passed away from it in her 60s.

Her brain is now providing important information on the pathology of dementia and potential treatments for Alzheimer’s disease since she lived dementia-free into her 70s.

The lady, from Medellin, Colombia, was a member of an extended family with a mutation in the PSEN1 gene, as researchers at Massachusetts General Hospital (MGH) and other institutions initially reported in 2019.

Because the PSEN1 E280A mutation is autosomal dominant, only one copy of the gene is necessary to cause disease.

This woman did not start displaying symptoms of Alzheimer’s until she was in her early 70s when carriers of the mutation normally display signs of the disease in their 40s or 50s and pass away from it shortly after. She passed away at the age of 77 in 2020 from metastatic melanoma.

“This is a ground-breaking case for Alzheimer’s disease and has already opened new paths for treatment and prevention, which we’re currently pursuing with some collaborators. This work is now bringing light into some of the mechanisms of resistance to Alzheimer’s disease” says investigator Yakeel T. Quiroz, Ph.D.

Quiroz is director of the Multicultural Alzheimer Prevention Program (MAPP) at Mass General, an Associate Professor of Psychology in the Department of Psychiatry at Harvard Medical School, and Paul B. and Sandra M. Edgerley MGH Research Scholar 2020-2025.

The key difference in the Colombian woman’s ability to fend off the disease for three decades appeared to be that in addition to having the PSEN1 E280A mutation, she was also a carrier of both copies of a mutation known as APOE3 Christchurch.

The APOE family of genes controls the production of apolipoproteins, which transport lipids (fats) in blood and other bodily fluids.

The APOE2 variant is known to be protective against Alzheimer’s dementia, while the APOE4 variant is linked to an increased risk for the disease.

APOE3, the most common variant, is not typically associated with either reduced or increased risk for Alzheimer’s.

As Quiroz and colleagues now report in the neuropathology journal Acta Neuropathologica, the woman did, in fact, have pathologic features of Alzheimer’s disease in her brain, but not in regions of the brain where the hallmarks of Alzheimer’s are typically found.

“This patient gave us a window into many competing forces — abnormal protein accumulation, inflammation, lipid metabolism, homeostatic mechanisms — that either promote or protect against disease progression, and begin to explain why some brain regions were spared while others were not,” says Justin Sanchez, AB, co-first author, and an investigator at MGH Neurology.

Researchers identified in Aliria’s brain a distinct pattern of abnormal aggregation or “clumping” of tau, a protein known to be altered in Alzheimer’s disease and other neurologic disorders.

In this case, the tau pathology largely spared the frontal cortex, which is important for judgment and other “executive” functions, and the hippocampus, which is important for memory and learning.

Instead, the tau pathology involved the occipital cortex, the area of the brain at the back of the head that controls visual perception.

The occipital cortex was the only major brain region to exhibit typical Alzheimer’s features, such as chronic inflammation of protective brain cells called microglia, and reduced levels of APOE expression.

“Thus, the Christchurch variant may impact the distribution of tau pathology, modulates age at onset, severity, progression, and clinical presentation of [autosomal dominant Alzheimer’s disease], suggesting possible therapeutic strategies,” the researchers write.

“It is seldom that we have nice surprises while studying familial Alzheimer’s disease brains. This case showed an amazingly clear protected phenotype. I am sure our molecular and pathologic findings will at least suggest some avenues of research, and elicit hope for a successful treatment against this disorder.”- says co-first author, Diego Sepulveda-Falla, MD, Research Lead at University Medical Center Hamburg-Eppendorf in Hamburg, Germany.

“This exceptional case is an experiment designed by nature that teaches us a way to prevent Alzheimer’s: let’s observe, learn and imitate nature,” concludes Francisco Lopera, MD, director of the Neuroscience Group of Antioquia in Medellín, Colombia. Lopera is a co-senior author and the neurologist who discovered this family and has been following them for the last 30 years.

Reference: “Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia” by Diego Sepulveda-Falla, Justin S. Sanchez, Maria Camila Almeida, Daniela Boassa, Juliana Acosta-Uribe, Clara Vila-Castelar, Liliana Ramirez-Gomez, Ana Baena, David Aguillon, Nelson David Villalba-Moreno, Jessica Lisa Littau, Andres Villegas, Thomas G. Beach, Charles L. White III, Mark Ellisman, Susanne Krasemann, Markus Glatzel, Keith A. Johnson, Reisa A. Sperling, Eric M. Reiman, Joseph F. Arboleda-Velasquez, Kenneth S. Kosik, Francisco Lopera and Yakeel T. Quiroz, 15 July 2022, Acta Neuropathologica.
DOI: 10.1007/s00401-022-02467-8

The study was funded by the National Institutes of Health, MGH Executive Committee on Research (MGH Research Scholar Award), Alzheimer’s Association, the Deutsche Forschungsgemeinschaft, Universidad de Antioquia, the Werner Otto Stiftung, and the German Federal Ministry of Education and Research.

7 Comments on "An Alzheimer’s-Proof Brain: Ground-Breaking Case Provides Clues to Treatment and Prevention of Dementia"

  1. Case Van Kleef | August 29, 2022 at 8:44 am | Reply

    I have a fear of Alzheimer decease. Being forgetful presently at age 89.
    Keep training me with sudoku and remembering playing cards. I am up to 30 and keep Eding one new card every week. Spelling sems to get harder.

  2. Gloria Naughton | August 29, 2022 at 8:56 am | Reply

    What are the implications of this in regards to Parkinsons Disease?

  3. How do I get tested for these genetic markers? My mom is dying from Alzheimer’s, but all I’ve seen in my 60’s is visual perception problems, e.g. I’ve lost the ability to judges distances. I’ve always had face blindness, but it’s getting worse. (Truth be known, not instantly recognizing things means I shouldn’t be driving, but I still drive 1000 miles a week.)

  4. It seems like nature is playing games with scientists. If nature wanted to prevent disorders, it could have done it by itself and not wait for a scientist to discover some cure by accident.

  5. I kept waiting g to hear how we can be tested for this gene. It’s like the breast cancer gene. My sister just found out she didnt carry the gene that would have demanded invasive surgery. Our father had Dementia and his sister does too. I would like to get tested for this.

  6. The DNA test from 23 and ME will give you your DNA. Your DNA can be downloaded to several services that can identify specific genes and advise you on possible ways to address them. I found I have copies of APOE3 and APOE4 which put me both at risk for Alzheimers and protect me from it.

  7. My mom had alzheimers, started about mid 40’s. I had the option to get tested for it but i was so young still and didn’t want anything like that hanging over me all the time. Why would anyone want that? Still glad that i didn’t all these years later.

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