Mediterranean Diet May Be the Ultimate Weapon Against Against Prostate Cancer

Rainbow Millet Vegetable Salad

Men who regularly consume a variety of colorful fruits and vegetables have a lower risk of being diagnosed with prostate cancer, according to two studies by University of South Australia researchers. These studies found that a Mediterranean or Asian diet, which includes a range of micronutrients, can help prevent prostate cancer and aid in recovery from radiation treatment for the disease. The research showed that low levels of certain micronutrients, such as lycopene and selenium, were associated with increased risk of prostate cancer and increased DNA damage after radiation exposure.

Rainbow of fruit and veg the best prevention against prostate cancer.

Men who consume colorful fruits and vegetables on a regular basis are less likely to be diagnosed with prostate cancer (PC), according to new research by University of South Australia scientists.

A rainbow of foods rich in certain micronutrients helps to prevent prostate cancer (PC) as well as speed up recovery among men who undergo radiation treatment for the disease.

The findings, from two studies published in the journal Cancers, highlight the importance of a Mediterranean or Asian diet that includes these foods.

Researchers compared micronutrient plasma concentrations of prostate cancer patients with a healthy control group, revealing low levels of lutein, lycopene, alpha-carotene, and selenium in PC patients and high levels of iron, sulfur, and calcium in the same group, relative to controls.

Increased DNA damage after radiation exposure was also associated with low lycopene and selenium in blood plasma.

Men with plasma concentrations lower than 0.25 micrograms (ug) per milliliter (mL) for lycopene and/or lower than 120ug/L for selenium have an increased risk of prostate cancer and are likely to be more sensitive to the damaging effects of radiation.

Foods that are rich in lycopene include tomatoes, melons, papayas, grapes, peaches, watermelons, and cranberries. Selenium-rich foods include white meat, fish, shellfish, eggs, and nuts.

Study co-author  Dr. Permal Deo says eating foods that are naturally rich in lycopene and selenium is preferable to taking supplements, where the benefits are limited, according to previous studies.

“Our recommendation is to adopt a Mediterranean diet enlisting the help of a dietician because people absorb nutrients in different ways, depending on the food, the digestive system, the person’s genotype, and possibly their microbiome,” Dr. Deo says.

Prostate cancer remains one of the most common and fatal cancers in men, but the nutritional deficiencies associated with it remain largely unknown, hence this study.

Other risk factors, such as ethnicity, family history, and age have previously been linked to prostate cancer.

“There is strong evidence that being overweight and tall increases the risk of prostate cancer. Diets high in dairy products and low in vitamin E may also increase the risk but the evidence is less clear.”

Vitamin E is found in plant-based oils, nuts, seeds, fruits, and vegetables.

The research is the first to evaluate plasma concentrations of micronutrients and trace elements with respect to prostate cancer in the South Australian population.


“Plasma Micronutrient Profile of Prostate Cancer Cases Is Altered Relative to Healthy Controls—Results of a Pilot Study in South Australia” by Varinderpal S. Dhillon, Permal Deo and Michael Fenech, 23 December 2022, Cancers.
DOI: 10.3390/cancers15010077

“Effect of Selenium and Lycopene on Radiation Sensitivity in Prostate Cancer Patients Relative to Controls” by Varinderpal S. Dhillon, Permal Deo and Michael Fenech, 3 February 2023, Cancers.
DOI: 10.3390/cancers15030979

These papers are authored by Dr. Varinderpal Dhillon, Dr. Permal Deo, and Professor Michael Fenech, all based in UniSA’s Clinical and Health Sciences unit.

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