New Research: Blood Pressure Highly Likely To Cause Neurotic Personality Trait

Crazy Old Woman Neurotic

Neurotic personality traits refer to a pattern of emotional instability, anxiety, and self-doubt. People with high levels of neurotic traits tend to experience negative emotions such as fear, guilt, and shame, and may be more prone to anxiety and mood disorders. They may also have difficulty coping with stress and uncertainty, and may engage in maladaptive behaviors such as avoidance or rumination. While neurotic traits are a normal part of human experience, high levels of neurotic traits can negatively impact an individual’s quality of life and functioning.

Managing it can help reduce neuroticism, anxiety, and the risk of cardiovascular disease.

A new study published in the open-access journal General Psychiatry found that high diastolic blood pressure, the lower number in a blood pressure reading, is highly likely to cause neurotic personality trait.

The researchers also suggest that managing diastolic blood pressure can help reduce neurotic behaviors, anxiety, and the risk of heart and circulatory diseases.

High blood pressure is a major risk for cardiovascular disease and is thought to be associated with psychological factors, such as anxiety, depression, and neuroticism—a personality trait characterized by susceptibility to negative emotions, including anxiety and depression.

But which causes which isn’t entirely clear.

In a bid to find out, the researchers used a technique called Mendelian randomization. This uses genetic variants as proxies for a particular risk factor—in this case, blood pressure—to obtain genetic evidence in support of a causal relationship, reducing the biases inherent in observational studies.

Between 30% and 60% of blood pressure is down to genetic factors, and over 1000 genetic single nucleotide polymorphisms, or SNPs for short, are associated with it. SNPs help predict a person’s response to certain drugs, susceptibility to environmental factors, and their risk of developing diseases.

The researchers drew on 8 large-scale study datasets containing whole genome DNA extracted from blood samples from people of predominantly European ancestry (genome-wide association studies).

They applied Mendelian randomization to the 4 traits of blood pressure—systolic blood pressure (736,650 samples), diastolic blood pressure (736,650), pulse pressure (systolic minus diastolic blood pressure; 736,650), and high blood pressure (above 140/90 mm Hg; 463,010) with 4 psychological states—anxiety (463,010 samples), depressive symptoms (180,866), neuroticism (170,911) and subjective wellbeing (298,420).

The analysis revealed that high blood pressure and diastolic blood pressure had significant causal effects on neuroticism, but not on anxiety, depressive symptoms, or subjective well-being.

But after adjusting for multiple tests, only diastolic blood pressure was significantly associated with neuroticism (over 90%), based on 1074 SNPs.

The researchers acknowledge certain limitations to their findings. For example, it wasn’t possible to completely exclude pleiotropy–where one gene can affect several traits. And the findings may not be more widely applicable beyond people of European ancestry.

But blood pressure links the brain and the heart, and so may promote the development of personality traits, they explain.

“Individuals with neuroticism can be sensitive to the criticism of others, are often self-critical, and easily develop anxiety, anger, worry, hostility, self-consciousness, and depression.

“Neuroticism is viewed as a key causative factor for anxiety and mood disorders. Individuals with neuroticism more frequently experience high mental stress, which can lead to elevated [blood pressure] and cardiovascular diseases,” they write.

And they suggest: “Appropriate surveillance and control of blood pressure can be beneficial for the reduction of neuroticism, neuroticism-inducing mood disorders, and cardiovascular diseases.”

Reference: “Investigating genetic causal relationships between blood pressure and anxiety, depressive symptoms, neuroticism and subjective well-being” by Lei Cai, Yonglin Liu and Lin He, 21 November 2022, General Psychiatry.
DOI: 10.1136/gpsych-2022-100877

The study was funded by the Natural Science Foundation of Shanghai. 

1 Comment on "New Research: Blood Pressure Highly Likely To Cause Neurotic Personality Trait"

  1. I have the answer. There is a homocystine re-methylation cycle share nutrients with Krebs cycle which related to energy.
    Elevated homocystine is because of MTHFR genetic variation. It body make less good enzymes.

    Elevated homocystine causes blood viscosity up to thrombosis when cold, and causes permability of cell walls. Like of nerve vessels and blood vessels and gut…

    There is a research that found correlation. When there is magnesium deficiency and b vitamin deficiencies body can’t make enough serotonin. It is well known that low serotonin causes depression.

    The related vitamins for homocysteine remethylation are a lot of folic acid b9, some b12 little bit more when memory issues, a little of b6.
    (Warning Don’t overdose on b6)

    Krebs cycle related vitamins are b1 b2 b3 b4 b6 b9 b12.

    The way depression starts is elevated adrenaline causes chronic depletion of limiting factors of krebs cycle, The b vitamins and minerals. Homocysteine remethylation when cold requires more folate and b12 when cold. So body can’t produce enough serotonin chronically also homocysteine causes nerve demage in brain.

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