New Yale Study Pinpoints Key Pathway in Inflammation and Aging

Study Pinpoints Key Pathway in Inflammation and Aging

Microscopic image of mitochondrial ROS, which indicates damage, in immune cells lacking the IL-10 signal.

A newly published study from Yale University details the critical role IL-10 plays in controlling inflammation and the possible implications for preventing or treating cell damage that often occurs with aging.

In patients with colitis, a serious condition affecting the gut, the immune system turns against the body’s own microbes, causing inflammation. To combat this inflammation, researchers have focused in on a chemical signal known as IL-10. While it’s understood that IL-10 plays a critical role in controlling inflammation and preventing colitis, it’s not clear how.

In a new study published in Science, immunobiologist and senior author Ruslan Medzhitov led a research team that examined the inflammatory response in mice and people lacking the IL-10 signal. They found that IL-10 works by blocking the metabolism of immune cells that are part of the inflammatory response. They also noted that IL-10 clears damaged mitochondria — the power generators within cells. The accumulation of this cellular damage in turn promotes inflammation.

The finding deepens understanding of a key process in inflammation, and could lead to therapies that target this pathway in colitis, said the researchers, and it also has implications for preventing or treating degenerative diseases that result from cell damage and often occur with aging.

Reference: “Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages” W. K. Eddie Ip, Namiko Hoshi, Dror S. Shouval, Scott Snapper and Ruslan Medzhitov, 5 May 2017, Science.
DOI: 10.1126/science.aal3535

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