The MyHPVscore test represents a successful translation of research from the laboratory to clinical practice.
A Michigan Medicine laboratory is now offering a groundbreaking cancer detection test.
Developed at the University of Michigan, MyHPVscore is a highly accurate blood test designed to detect head and neck cancers associated with human papillomavirus (HPV). The test works by identifying small fragments of tumor DNA circulating in a patient’s bloodstream.
“We needed to create this lab because patients needed results,” said J. Chad Brenner, Ph.D., director of the Michigan Otolaryngology and Translational Oncology Laboratory, where the tests are developed and processed. “There are almost no otolaryngology departments nationally that have such a lab.”
The clinical laboratory, a collaboration between the departments of Otolaryngology and Pathology, was established in July 2022. After successfully validating its testing procedures, the lab began processing patient samples in October 2024.
Capacity and Future Plans
The first patient samples came from Michigan, but the lab plans to offer national testing soon.
They have the capacity to run 400 samples per day, and plan to begin running about 50 per day in the next year as testing carefully ramps up.
Around 48,000 patients receive diagnoses of HPV+ cancer in the United States every year.
The ability to detect such cancers with a simple blood test has obvious benefits as a noninvasive diagnostic tool.
MyHPVscore also allows doctors and patients to more easily assess how treatments are working.
“The work of Dr. Brenner and his team is incredibly exciting,” said Keith Casper, M.D., U-M clinical associate professor for Otolaryngology-Head and Neck Surgery.
“This test has the ability to detect recurrent disease before patients have any signs or symptoms of recurrence. It also can detect recurrence prior to any imaging findings. This opens the possibility of being able to detect recurrence at its earliest stage, which should enable us to intervene earlier.”
Rising Need for Advanced Diagnostics
HPV-related head and neck cancers have risen in incidence and are predicted to continue to do so, given the latent nature of the virus.
Most young adults have not received the HPV vaccine, with a particularly low rate for men, even though it is now approved for adults up to the age of 45.
Michigan’s lab is the first to debut a circulating biomarker test for patients with HPV-related head and neck cancer.
Brenner credits their being first to University of Michigan Health’s willingness to provide multidisciplinary support to quickly translate his team’s idea to a test that helps patients.
“There are so few examples of tests that have been advanced—from development to returning results to patients— within a single institution,” Brenner said. “That’s really the uniqueness of the Rogel Cancer center.”
Future Applications and Broader Impact
As the Michigan Otolaryngology and Translational Oncology Laboratory rolls out MyHPVScore for a growing number of patients, they are also working to develop tests for related cancers, such as HPV-positive cervical cancer.
HIV-positive and other immunocompromised patients, who develop HPV-related cancers at a much higher rate, also stand to potentially benefit more than any other group from expanded applications of the test.
Brenner also hopes the success of the lab will encourage other researchers to pursue their ideas for novel tests—and make Michigan a leader in true bench-to-bedside translation.
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