A new study by Italian researchers has found that some coronaviruses can incorporate host genes into their genome to evade the immune system.
Some coronaviruses can add to their genetic pool some genes belonging to the host they infected. In this way, they can blend in and be less detectable to the immune system. This discovery was published in the journal Viruses by an Italian research team from the IIS (Italian Healthcare Institute), ISPRA (Institute for Environmental Protection and Research), IZSLER (Italian health authority and research organization for animal health and food safety of Lombardy and Emilia-Romagna) and the University of Bologna.
The outcome of this study demonstrates that coronaviruses encompass a sophisticated evolutionary mechanism and therefore puts increasing emphasis on the importance of studying wildlife diseases. Research in this field is fundamental to understand the functioning of illnesses that can spread from animals to humans so that we can efficiently manage ecosystems and provide a balance between the species inhabiting them,” says Mauro Delogu, a researcher at the University of Bologna and one of the authors of this study.
Researchers discovered this while analyzing coronaviruses found in specimens of European hedgehogs (Erinaceus europaeus). They classified this strain as EriCoV. These viruses belong to the same strain of Beta-CoV responsible for COVID-19 as well as MERS. However, there is no evidence that they can spread to humans.
Gene Theft and Immune Evasion
These hedgehog coronaviruses are able to steal a gene (CD200) that belongs to the host. When combined with its receptor, this gene prevents an excessive inflammatory response. By incorporating this gene, the virus can hinder the immune defense of the host.
Events like this have never been observed before in coronaviruses. With this evolutionary strategy, coronaviruses can influence the duration of the infection and therefore prolong the time necessary to eliminate the virus, eventually leading to chronic infections. This process goes to the advantage of the virus, as it multiplies its ability to propagate and spread thanks to a specific evolutionary strategy.
“These results pave the way for further investigations into the ability of coronaviruses to interfere with the inhibitory signals of immune cells,” continues Delogu. “In this way, coronaviruses can disguise themselves so that it is harder for the immune system of the host to detect, recognize, and destroy them.”
Reference: “Can Coronaviruses Steal Genes from the Host as Evidenced in Western European Hedgehogs by EriCoV Genetic Characterization?” by Luca De Sabato, Ilaria Di Bartolo, Maria Alessandra De Marco, Ana Moreno, Davide Lelli, Claudia Cotti, Mauro Delogu and Gabriele Vaccari, 20 December 2020, Viruses.
DOI: 10.3390/v12121471
Viruses Journal published this study titled “Can Coronaviruses Steal Genes from the Host as Evidenced in Western European Hedgehogs by EriCoV Genetic Characterization?” Claudia Cotti and Mauro Delogu from the Service for Wildlife at Department of Veterinary Medical Sciences of University of Bologna are co-authors of the study.
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