New Approach to Gene Therapy: Prime Editing System Inserts Entire Genes in Human Cells
A CRISPR-based gene editing technique called twin prime editing could be a new and safer approach to gene therapy. Researchers at the Broad Institute of…
Broad Institute
Next Generation Prime Gene Editing Systems Expands Technology’s Therapeutic and Research Applications
Researchers have boosted the efficiency of prime editing, a highly versatile CRISPR-based gene editing technology, and used the improved system to correct disease mutations in…
Scientists Harness Human Protein To Deliver RNA Molecular Medicines to Cells
Made of components found in the human body, the programmable system is a step toward safer, targeted delivery of gene editing and other molecular therapeutics….
Early Antiviral Response in the Nose May Determine Mild / Severe Course of COVID-19
Cells taken from patients at the time of diagnosis who later developed severe COVID-19 show a muted antiviral response, study finds. Researchers studied cells collected…
High Capacity DNA Data Storage: Could All Your Digital Photos Be Stored As DNA?
A technique for labeling and retrieving DNA data files from a large pool could help make DNA data storage feasible. On Earth right now, there…
New Cell Atlas of COVID-19 Pathology Reveals How the Coronavirus “Wreaks Havoc in the Lungs”
Single-cell analysis of autopsy samples from COVID-19 patients shows how the lungs repeatedly tried, and failed, to repair themselves. Scientists from several hospitals and research…
Metabolic Genetic Mutations Help Bacteria Resist Drug Treatment
Study suggests forcing bacteria to burn more energy could make them more susceptible to antibiotics. Bacteria have many ways to evade the antibiotics that we…
Turning New Discoveries About the Trillions of Microbes in Our Bodies Into Treatments for a Range of Diseases
A diverse group of researchers is working to turn new discoveries about the trillions of microbes in the body into treatments for a range of…
Zoonomia Project: Largest Set of Mammalian Genomes Reveals Species at Risk of Extinction
The Zoonomia Project has released this vast dataset to advance both biomedical research and biodiversity conservation. An international team of researchers with an effort called…
MIT’s New CRISPR-Based Rapid Test for COVID-19 Shows Improved Sensitivity
A CRISPR-based test developed at MIT and the Broad Institute can detect nearly as many cases as the standard Covid-19 diagnostic. Since the start of…
Microbiome Library – A Comprehensive Catalog of Human Digestive Tract Bacteria
Researchers identify nearly 8,000 strains of bacteria, while also clarifying their genetic and metabolic context. The human digestive tract is home to thousands of different…
Researchers Develop New Method for Making “Blood Biopsies”
A team of scientists at the Broad Institute, the Koch Institute for Integrative Cancer Research, Dana-Farber Cancer Institute, and Massachusetts General Hospital have developed a…
Scientists Overcome Key CRISPR-Cas9 Genome Editing Hurdle
Using structural knowledge of Cas9, scientists have overcome a key CRISPR-Cas9 genome editing hurdle and developed a highly specific genome-editing tool. Researchers at the Broad…
Bioengineers Develop a New System for Human Genome Editing
A team of scientists from MIT, Harvard and Wageningen University have developed a new system for human genome editing that has potential to increase the…
Researchers Create Engineered Particles that Kill Harmful Bacteria
Deadly to targeted bacteria, engineered particles known as phagemids have been created to fight bacterial infections with great effectiveness while eliminating harmful side effects of…
CMS Test to Detect the Genetic Signals of Positive Selection
Researchers from the Broad Institute have developed a tool known as the Composite of Multiple Signals (CMS) test to detect the genetic signals of positive…
HMP Maps the Healthy Human Microbiome
With microbes outnumbering human cells by 10 to 1, the Human Microbiome Project (HMP) Consortium looks at how these microorganisms coexist with their human hosts…