Harvard University and Broad Institute researchers use 3D, miniature models of the human brain to advance disease understanding. Autism spectrum disorder has been associated with…
Single-cell gene expression analyses of human cerebrovascular cells can help reveal new drug targets for Huntington’s disease. While neurons and glial cells are by far…
A CRISPR-based gene editing technique called twin prime editing could be a new and safer approach to gene therapy. Researchers at the Broad Institute of…
Researchers have boosted the efficiency of prime editing, a highly versatile CRISPR-based gene editing technology, and used the improved system to correct disease mutations in…
Made of components found in the human body, the programmable system is a step toward safer, targeted delivery of gene editing and other molecular therapeutics….
Cells taken from patients at the time of diagnosis who later developed severe COVID-19 show a muted antiviral response, study finds. Researchers studied cells collected…
A technique for labeling and retrieving DNA data files from a large pool could help make DNA data storage feasible. On Earth right now, there…
Single-cell analysis of autopsy samples from COVID-19 patients shows how the lungs repeatedly tried, and failed, to repair themselves. Scientists from several hospitals and research…
Study suggests forcing bacteria to burn more energy could make them more susceptible to antibiotics. Bacteria have many ways to evade the antibiotics that we…
A diverse group of researchers is working to turn new discoveries about the trillions of microbes in the body into treatments for a range of…
The Zoonomia Project has released this vast dataset to advance both biomedical research and biodiversity conservation. An international team of researchers with an effort called…
A CRISPR-based test developed at MIT and the Broad Institute can detect nearly as many cases as the standard COVID-19 diagnostic. Since the start of…
Researchers identify nearly 8,000 strains of bacteria, while also clarifying their genetic and metabolic context. The human digestive tract is home to thousands of different…
A team of scientists at the Broad Institute, the Koch Institute for Integrative Cancer Research, Dana-Farber Cancer Institute, and Massachusetts General Hospital have developed a…
Using structural knowledge of Cas9, scientists have overcome a key CRISPR-Cas9 genome editing hurdle and developed a highly specific genome-editing tool. Researchers at the Broad…
A team of scientists from MIT, Harvard and Wageningen University have developed a new system for human genome editing that has potential to increase the…
Deadly to targeted bacteria, engineered particles known as phagemids have been created to fight bacterial infections with great effectiveness while eliminating harmful side effects of…
Researchers from the Broad Institute have developed a tool known as the Composite of Multiple Signals (CMS) test to detect the genetic signals of positive…
