Scientists Sequence the Genome of the World’s Oldest Continuously Surviving Cancer

January 24, 2014

Biology

Genome of Oldest Cancer Reveals Its Origin and Evolution

Researchers have sequenced the genome of an 11,000-year-old dog cancer, revealing its secrets and origin.

Scientists have sequenced the genome of the world’s oldest continuously surviving cancer, a transmissible genital cancer that affects dogs. This cancer, which causes grotesque genital tumors in dogs around the world, first arose in a single dog that lived about 11,000 years ago. The cancer survived after the death of this dog by the transfer of its cancer cells to other dogs during mating.

The genome of this 11,000-year-old cancer carries about two million mutations – many more mutations than are found in most human cancers, the majority of which have between 1,000 and 5,000 mutations. The team used one type of mutation, known to accumulate steadily over time as a ‘molecular clock’, to estimate that the cancer first arose 11,000 years ago.

Dr Elizabeth Murchison and Professor Sir Mike Stratton discuss the history and evolution of an ancient cancer that has been spreading through the dog population for thousands of years.

“The genome of this remarkable long-lived cancer has demonstrated that, given the right conditions, cancers can continue to survive for more than 10,000 years despite the accumulation of millions of mutations”, says Dr Elizabeth Murchison, first author from the Wellcome Trust Sanger Institute and the University of Cambridge.

The genome of the transmissible dog cancer still harbors the genetic variants of the individual dog that first gave rise to the cancer 11,000 years ago. Analysis of these genetic variants revealed that this dog may have resembled an Alaskan Malamute or Husky. It probably had a short, straight coat that was colored either grey/brown or black. Its genetic sequence could not determine if this dog was a male or a female, but did indicate that it was a relatively inbred individual.

“We do not know why this particular individual gave rise to a transmissible cancer,” says Dr Murchison, “But it is fascinating to look back in time and reconstruct the identity of this ancient dog whose genome is still alive today in the cells of the cancer that it spawned.”

Transmissible dog cancer is a common disease found in dogs around the world today. The genome sequence has helped scientists to further understand how this disease has spread.

“The patterns of genetic variants in tumors from different continents suggested that the cancer existed in one isolated population of dogs for most of its history,” says Dr Murchison. “It spread around the world within the last 500 years, possibly carried by dogs accompanying seafarers on their global explorations during the dawn of the age of exploration.”

Transmissible cancers are extremely rare in nature. Cancers, in humans and animals, arise when a single cell in the body acquires mutations that cause it to produce more copies of itself. Cancer cells often spread to different parts of the body in a process known as metastasis. However, it is very rare for cancer cells to leave the bodies of their original hosts and to spread to other individuals. Apart from the dog transmissible cancer, the only other known naturally occurring transmissible cancer is an aggressive transmissible facial cancer in Tasmanian devils that is spread by biting.

“The genome of the transmissible dog cancer will help us to understand the processes that allow cancers to become transmissible,” says Professor Sir Mike Stratton, senior author and Director of the Sanger Institute. “Although transmissible cancers are very rare, we should be prepared in case such a disease emerged in humans or other animals. Furthermore, studying the evolution of this ancient cancer can help us to understand factors driving cancer evolution more generally.”

This work was supported by the Wellcome Trust, the Kadoorie Charitable Foundation, and a L’Oreal-United Nations Educational, Scientific, and Cultural Organization for Women in Science Fellowship.

Publication: Elizabeth P. Murchison, et al., “Transmissable Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage,” Science 24 January 2014: Vol. 343 no. 6169 pp. 437-440; DOI: 10.1126/science.124716

Source: Wellcome Trust Sanger Institute

Image: University of Cambridge

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2 Responses to “Scientists Sequence the Genome of the World’s Oldest Continuously Surviving Cancer”

  1. Madanagopal.V.C Says:

    Cancer is the ultimate disease in aging. It is due to the mutations or copying mistakes done when the cell divides over the lifetime. Don’t we know that mostly aged people, if they can survive all the life style diseases or bacterial ailments end up in one type of cancer or the other? Thus there seems to be a biological plan to corrupt the genomes which is generally inherited by all humans. This dog cancer has got several million mutations as against human cancer with some thousands only. Hence, this cancer is carried through such a long period in generations in Dogs. No doubt, it is inherited by dog’s descendants and why don’t we conclude that humans also inherit their dreadful disease in their genome only? The mutations are sped up by harmful radiations and harmful chemicals in their food. The plan to get the genome corrupt is already there in human genome copied through generations. For any humans who wants to live long overcoming all the diseases , the cancer is sure to come when they age very old. It seems to be a natural culmination of growth. Few humans are unfortunate to get it at an early stage due to carcinogenic factors in their lives. Thank You.

    Reply

  2. ann Says:

    How many cancers are caused by mutations due to radiation in our food and water affecting DNA and cells?

    Did you know that radiation (isotopes) are “allowed” in our food and water?

    This radiation came from atomic testing, atomic meltdowns like Chernobyl and Fukushima, and nuclear power plants (which release radiation during their day-to-day operations.)

    This radiation can cause cancers, heart disease, birth defects, etc.

    Reply

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