90% Reduction: Scientists Discover Natural Molecule That Eradicates Plaques and Cavities

Dental Cavities Chewing Teeth

Scientists have discovered that the molecule DIM reduces biofilms causing dental plaque by 90%. Its addition to toothpaste and mouthwash could revolutionize dental hygiene.

3,3′-Diindolylmethane (DIM) decreased the Streptococcus mutans biofilm, a leading contributor to plaque and cavities, by 90%.

A significant portion of the global population experiences persistent issues with dental plaque and cavities or will face them at some time. While toothpaste, mouthwash, and routine dental visits help in prevention, there’s always room for improvement.

Researchers from Ben-Gurion University of the Negev, in collaboration with teams from Sichuan University and the National University of Singapore, have identified that 3,3′-Diindolylmethane (DIM) – a naturally occurring molecule also referred to as bisindole – can reduce biofilms responsible for plaque and cavities by a remarkable 90%.

The molecule is also found to have anti-carcinogenic properties.

Their findings were recently published in the journal Antibiotics.

Your mouth is a great reservoir for bacteria such as S. mutans, which is believed to be one of the primary actors in dental cavities. S. mutans grows in the moist and sugary atmosphere of your mouth after food in a biofilm that coats your teeth. Biofilm generates plaque, attacks enamel, and causes cavities. The scientists found that the bisindole (DIM) disrupted that biofilm by 90% and therefore the bacterium was not given a chance to grow.

“The molecule, which was found to have low toxicity, could be added to toothpastes and mouthwashes to greatly improve dental hygiene,” says lead author Prof. Ariel Kushmaro of the Avram and Stella Goldstein-Goren Department of Biotechnology Engineering. He is also a member of the Ilse Katz Institute for Nanoscale Science and Technology and the Goldman Sonnenfeldt School of Sustainability and Climate Change.

Reference: “3,3′-Diindolylmethane (DIM): A Potential Therapeutic Agent against Cariogenic Streptococcus mutans Biofilm” by Yifat Baruch, Karina Golberg, Qun Sun, Karina Yew-Hoong Gin, Robert S. Marks and Ariel Kushmaro, 6 June 2023, Antibiotics.
DOI: 10.3390/antibiotics12061017

The study was conducted with his student Yifat Baruch, and Dr. Karina Golberg, as well as Prof. Robert S. Marks of the same department and Qun Sun of Sichuan University, and Karina Yew-Hoong Gin of the National University of Singapore.

The research was supported by the International Research and Development Program of Sichuan (2019YFH0113) and SMART innovation grant ING-000398 (Singapore).

39 Comments on "90% Reduction: Scientists Discover Natural Molecule That Eradicates Plaques and Cavities"

  1. It’s a useful achievement in dental hygiene & care. Can’t wait to have it as an ingredient of daily dental care products like toothpaste, mouthwash, etc.

  2. I’m curious what it does with the good and critical bacteria in your mouth you dont want to get rid of.

  3. Parodontax seems to work well. Would this do a better job?

  4. For anyone unaware, DIM is a compound found in broccoli.

  5. Antonio Bragança Martins | September 8, 2023 at 6:32 pm | Reply

    The natural molecule is called baking soda! I have used it for 20 years and I haven’t plaques or cavities! But your dentist don’t want you know it!

  6. It will take 10-15 years to get this in toothpaste.

    How about re-growing teeth? They have been working on that for decades. If Sharks can do, we should be able to do it.

    • I totally agree, & have in fact had that very same thought as well! Plus we lose one set of teeth already, so we must somewhat have the capability already!

  7. They won’t want us to have it. These guys have made tons of money off of us for years… you think they are just gonna give it up?? Highly unlikely.

  8. I’m guessing the DIM in broccoli and other cruciferous veggies isn’t really broken down in your mouth as you’re chewing. It’s sold in Capsules so one could easily just open the capsules and dip your brush in it.

    Another question is if it disrupts biofilm, could it be used to help stop surgical site infections?

    • Dental floss and brushing teeth with nothing on it is doing best job. Adding a flavour of a toothpaste is just changing your morning taste and smell. That is all a toothpaste doing. All what is in it, going to your stomach so be aware of its content. Keep simple and clean will bring you health and cavity free. Adding “stuff” growing pockets only.

  9. Great Findings

  10. I have a cousin who had 3 sets of teeth.

  11. George Anderson | September 9, 2023 at 9:03 am | Reply

    I have found the same results and possibl, but much more economical the controls Staphylococcus A.bacteria that causes tooth decay, heart plaque, boils on the skin, atopic dermatitis, eczema, hemroids and several other Staph. A. infections. The natural product does not cause erosion of enamel on the teeth.

    • Would you be willing to share what this natural product you found to be this beneficial is? And the method on how to use it for the best desired results? Thanks so much!, if you can share that information, you would be helpful to so many people perhaps.

  12. Your taking it at face value put some thought into it they are obviously increasing the DIM up to levels where it takes effect hence them saying it’s low in toxins so this is an Optimal choice

  13. The folks deep in some small villages in Ugandan,seem to have naively been aware of the benefits of certain plants thus the strong healthy white teeth they posses.

  14. Don’t hold your (bad) breath. They often come up with these findings in Israel and they’re almost never implemented.

  15. So I went tobthe dentist a year ago (I’m aged 45) and had zero issues with my teeth. Now, I had gone for years with brushing maybe 2 to 3 times per month. Never had had breath, never in my life had cavities or any other issues. Dentist said they “hate” people like me and chalked it up to genetics.
    Makes me wonder what my body does differently thanb5he other 90% of the population.

  16. Stephen muccini | September 9, 2023 at 3:56 pm | Reply

    Dentists wouldn’t like this to go public…..

  17. Okay but what happens if you swallow it? Any studies on that?

    • Umm… DIM is a common Supplement take to to help with estrogen control. Do people ever bother to research something before they post.

  18. Ah, great! Another Fluoride to slowly poison the children…

    • Did you even bother to Google dim? What it comes from (cruciferous veggies) and what it does? My guess is no.

    • Fluoride occurs naturally in water in many areas of the US, especially the SW. I live in MI, and my well water naturally contains 75% of the fluoride recommended to prevent cavities. Fluoride is only a poison if too much is ingested, as with vitamin A. My daughter’s skin turned orange when she was a toddler from ingesting too much Vitamin A/keratin. She loved carrots, orange squash, sweet potatoes, etc. That doesn’t mean that Vitamin A is a poison.

  19. LIFE IS COMPLEX LETS NOT MAKE IT COMPLICATED AND HARD GO BACK TO THE BASICS. WHERE ITS EASY TO GAIN THE NEED WHICH IS IN UNDERSTANDING THAT IT TAKES TWO TO GAIN ANY AND EVERYTHING! GIVEN TO TAKE GIVES MOTION I had a nasty cut on my schin that became infected and 8 months RX’d a variety of antibiotics yet to no avail. In my own research I FINALLY tried putting white table sugar on the wound. Which kept a white film on top not giving way to scab over; the morning after I put the table sugar on top, miraculously the white film was GONE! I SPRINKLED MORE SUGAR ON TO IT FOLLOWED WITH MANUKA HONEY and later SAME afternoon it grew a scab. Repeated that the following day at which the 1″ diameter wound that was almost to my bone, was as a fraction a size. In a matter of 4 days the cut was HEALED! HEALED it’s been a little over a year and there is minimal scar. I have never before this wound took a “full course” of antibiotics either, EXCEPT during this time of attempting to heal this wound. Wherein antibiotics did not help. I have come to conclusion that the antibiotics gave more harm than help. When either my child or I feel like we are coming down with an illness, we take in combination extra ZINC & L-LYSINE. My child is now 16 1/2 and has only taken an antibiotic 2 times in life. At which NEVER had a “full” course of either. Once the “symptoms” are gone it is immediately stopped. Never have we had a “recourse”. Knock on wood neither of us have had Co-vid and we have been around others who have had it. Neither of us get the flu or co-vid Vaccines either. We also are not fanatics in with washing our hands after everything we touch or in using hand sanitizers. My child was born with congenital differences where we had genetic tests done was told we both have a gene variant that aids in prevention of the flu; idk I’m not a scientist. Only I do know we humans are all different where I believe the proper term is just UNIQUE. In summary I think the issue came from a problem where the solution stemmed gave to the change where it became problematic. Due to the lack of respect was not given the equally. Where all give differently we give to the same where in the combination of us together gives the one fact where the problem holds to the value called the EQUAL. WHERE THE SOLUTION DID NOT GIVE TO ALL EQUALLY FOR ONE TOOK THE GREATER VALUE SOLVING THE PROBLEM FOR SELF LEAVING OTHERS WITH LESS OF THE GAIN.THE GIVEN PROBLEM WAS NOT RESOLVED. WHERE THE SOLUTION GAVE WAY TO ONE CAME BY ANOTHER WHO SAW MANY HAD A SIMILAR NEED HE FOR TOOK THE OPPORTUNITY TO TAKE FOR HIMSELF SO HE TOOK THE LEAD. WHERE THOSE IN NEED HAD SEEN THE WAY HE SOLVED PROBLEM FOR ONE THEY GAVE THEIR TRUST TO HIM NOT THINKING TO FIRST GAIN THE TRUTH IN UNDERSTANDING WHERE THE DRIVING FORCES STEMS. SO THIS ONE GAVE THE SAME AS HE GAVE TO THE OTHER WHICH BECAUSE WE ARE ALL DIFFERENT THE SOLUTION DID NOT SOLVE THE PROBLEM DUE TO OUR DIFFERENCES. WHICH LED TO THE WAYS OF CHANGE THAT IS GIVEN FROM TIME. FOR THE TRUTH IS OUR ABILITY TO CHANGE COMES BY TIME. WHERE THE MOTION THAT GIVES COMES FROM TWO FIELDS THAT CAME WITH NEED WHERE EACH HOLD EQUAL TO THE SAME WHERE BY GIVING SERVES THE ONE PURPOSE. EQUALLY GAIN THE INTEREST WHERE YOU HAVE BEEN GIVEN THE CHOICE TO GIVE YOUR ATTRIBUTE TO ONE SIDE OR THE OTHER. AND SINCE WE ARE HUMANS WE DO MAKE MISTAKES. THE WAYS OF THE FOOL HAS THE SAME POWER AS THE WISE OF THE WISE. ITS ALL IN THE MANNER OF COMMUNICATION. SEE WE SIMPLY ARE ALL REACTING TO THE FACT WHERE BY TWO WE HAVE BECOME ALIVE. AT OUR OWN START OF OUR OWN JOURNEY IS THE BEGINING TO WHERE IN ANY GIVEN MOMENT OUR ABILITY TO CHOOSE WILL CHANGE SIMPLY BT THE GIFT FROM TIME. WHERE ALL LIVING WILL COME TO THE END BY DEATH. LIFE BELONGS NO ONE IT IS SHARED. No One’s Journey has the ability to “survive” Life living! We have the ability to give all that we are given towards the betterment of all. Accepting the facts that in the given lies the the truth no matter if you like it or not it’s just the reality where we are different we get just the same equally. Their are many many factors in play that change the value in the same given that makes a world of difference! Where in reality when one does not share the all they know in sharing the full details in the given fact creates the way where in the given truth leads to a false understanding where the the true value becomes where the given perception is not true in the truth lies in reality time gives the changes. The wolf in sheeps clothing speaks in a manner that gives the deception controlled by the negative who takes for their self. While they taunt I EARNED IT MYSELF BY GIVING MORE EFFORT, IS SIMPLY A ILL MANNERED FOOLISH INDIVIDUAL WHO HAS BEEN FOOLED BY THE FOOL! ITS THE NEGATIVE THAT TAKES AWAY FROM THE WHERE THE FORCE OF POSITIVE IS HURTING & STRUGGLING NOT HEALED OR HELPED. ITS A LACK OF RESPECT DUE TO THE GREATER of RESPECT IS GIVEN TO THE LOVE OF SELF. Where one will eventually take it all for self. ONE SELF will eventually become starved, weakened and weary. There will be no reason of purpose. NO driving force for will to change. There is nothing that gives
    to receive. Alone and lonely, no joy in giving no joy to receive. No respect to earn No respect to gain. Love the love of life is gone. The fooled fooled you to act foolishly taking for self not giving the respect to others who you did not see them as equal value. AND so no one is left Life has left and to hell with the ways of wicked! Change give back all you got it’s the way to gain anyways. Life is complex learn to accept the interesting ways of the wise where the interest is gives to best where in better is just that it’s BETTER!! There is no less nor more in the FACT THAT GIVES THE EQUAL. THE VALUE IS EITHER MORE OR LESS.PERIOD. ITS THE DESIGN OF NATURE


    • Can you please message me
      I have deep questions thks

    • By stopping the antibiotics before the full course is over, you are contributing to the problem of antibiotic resistance bacteria…not all of the bacteria from the infection are killed. The bacteria that do survive become resistant to the antibiotics they were exposed to…what doesn’t kill you makes you stronger. That is the reason scientists have had to create stronger & different antibiotics over the years. There are some bacteria for which there is no effective antibiotics, due to their resistance. If you do not intend to take the full course of antibiotics, it’s better not to take the antibiotics at all. Instead of antibiotics, find one of your natural remedies that is effective.

  20. Say what?????????!!!

  21. Simply: Some positive sentiments. It is a worthy lifelong goal to try to become aware of and balance the idea of greed and giving. I would importantly add that in trying to FORCE equality and conquer greed is often a very destructive idea because the traits that compel people to take risks to spend money to build a business could be seen as the “greed” to make money. Whether we like it or not “greed” driven pursuits have lifted so many out of poverty than say communistic “equality” pursuits. This is not to say that we shouldn’t develop charity and pursue ways to help others. We have to find ways to create equality in ways that are are voluntary, gradual a paradigmal (teaching, life changing, motivational etc) rather than forced because that leads to the autocities at totalitisms’ wake. IE Solgenitsm

  22. Diindolylmethane is already in use for preventing breast, uterine and colorectal cancer. It is also used as a preventive in prosate enlargement. As well as, used in treating premenstrual syndrome. So, what are we talking about here – “toxicity?”

  23. Does anyone know what form of DIM was used in the test? You can easily buy this supplement in capsules, open them up, and sprinkle on your toothpaste. Would that form of DIM accomplish the same thing?

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