Penn study suggests cardiac arrests and arrhythmias are likely triggered by systemic illness, not solely due to the viral infection itself.
Patients with COVID-19 who were admitted to an intensive care unit were 10 times more likely than other hospitalized COVID-19 patients to suffer cardiac arrest or heart rhythm disorders, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.
Researchers say the results suggest that cardiac arrests and arrhythmias suffered by some patients with COVID-19 are likely triggered by a severe, systemic form of the disease and are not the sole consequence of the viral infection. The findings — which differ significantly from early reports that showed a high incidence of arrhythmias among all COVID-19 patients — provide more clarity about the role of the novel coronavirus, SARS-COV-2, and the disease it causes, COVID-19, in the development of arrhythmias, including irregular heart rate (atrial fibrillation), slow heart rhythms (bradyarrhythmia) or rapid heart rate that stops by itself within 30 seconds (non-sustained ventricular tachycardia).
The study was published today (June 22, 2020) in the journal Heart Rhythm — the official journal of the Heart Rhythm Society.
“In order to best protect and treat patients who develop COVID-19, it’s critical for us to improve our understanding of how the disease affects various organs and pathways within our body — including our heart rhythm abnormalities,” said the study’s senior and corresponding author Rajat Deo, MD, MTR, a cardiac electrophysiologist and an associate professor of Cardiovascular Medicine at Penn. “Our findings suggest that non-cardiac causes such as systemic infection, inflammation, and illness are likely to contribute more to the occurrence of cardiac arrest and arrhythmias than damaged or infected heart cells due to the viral infection.”
Recent studies from China have suggested that COVID-19 is associated with a high incidence of cardiac arrhythmias, particularly among critically ill patients — early reports showed 44 percent of patients admitted to the ICU suffered arrhythmias. Heart rhythm problems occur when electrical impulses that coordinate your heartbeats don’t work properly, causing your heart to beat too fast, too slow, or irregularly. If left untreated, cardiac arrhythmias can lead to serious medical conditions, including stroke and cardiac arrest — the abrupt loss of heart function.
To evaluate the risk and incidence of cardiac arrest and arrhythmias among hospitalized patients with COVID-19, the Penn team evaluated 700 patients with COVID-19 who were admitted to the Hospital of the University of Pennsylvania between early March and mid-May. Researchers evaluated cardiac telemetry and clinical records for patient demographics and medical comorbidities — such as heart disease, diabetes and chronic kidney disease — and recorded patient vitals, test results, and treatment.
The cohort of patients had a mean age of 50 years, with Black patients accounting for more than 70 percent of the population. Researchers identified a total of 53 arrhythmic events: nine patients who suffered cardiac arrest, 25 patients with atrial fibrillation who required treatment, nine patients with clinically significant bradyarrhythmias, and 10 non-sustained ventricular tachycardia events. The team did not identify any cases of heart block, sustained ventricular tachycardia, or ventricular fibrillation.
Of the 700 patients hospitalized, about 11 percent were admitted to the ICU. None of the other hospitalized patients suffered a cardiac arrest. After controlling for underlying demographic and clinical factors, researchers found cardiac arrest and arrhythmias were more likely to occur among patients in an ICU compared to the other hospitalized patients.
Researchers noted that the study has several limitations, including that the analysis was conducted from a single center serving a large urban population.
“More research is needed to assess whether the presence of cardiac arrhythmias have long-term health effects on patients who were hospitalized for COVID-19,” Deo said. “In the meantime, it’s important that we launch studies to evaluate the most effective and safest strategies for long-term anticoagulation and rhythm management in this population.”
Reference: “COVID-19 and Cardiac Arrhythmias” by Anjali Bhatla, BA; Michael M. Mayer, BS; Srinath Adusumalli, MD, MSc; Matthew C. Hyman, MD, Ph.D.; Eric Oh, MS; Ann Tierney, MS; Juwann Moss, BS; Anwar A. Chahal, MD, Ph.D.; George Anesi, MD, MSCE, MBE; Srinivas Denduluri, Ph.D.; Christopher M. Domenico, PharmD; Jeffrey Arkles, MD; Benjamin S. Abella, MD, MPhil; John R. Bullinga, MD; David J. Callans, MD; Sanjay Dixit, MD; Andrew E. Epstein, MD; David S. Frankel, MD; Fermin C. Garcia, MD; Ramanan Kumareswaram, MD; Saman Nazarian, MD, Ph.D.; Michael P. Riley, MD, Ph.D.; Pasquale Santangeli, MD, Ph.D.; Robert D. Schaller, DO; Gregory E. Supple, MD; David Lin, MD; Francis Marchlinski, MD and Rajat Deo, MD, MTR, 22 June 2020, Heart Rhythm.
Additional Penn authors include Anjali Bhatla, Michael M. Mayer, Srinath Adusumalli, Matthew C. Hyman, Eric Oh, Ann Tierney, Juwann Moss, Anwar A Chahal, George Anesi, Srinivas Denduluri, Christopher M. Domenico, Jeffrey Arkles, Benjamin S. Abella, John R. Bullinga, David J. Callans, Sanjay Dixit, Andrew E. Epstein, David S. Frankel, Fermin C. Garcia, Ramanan Kumareswaram, Saman Nazarian, Michael P. Riley, Pasquale Santangeli, Robert D. Schaller, Gregory E. Supple, David Lin, and Francis Marchlinski.
The research was supported, in part, by the Winkelman Family Fund in Cardiovascular Innovation.
Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the (founded in 1765 as the nation’s first medical school) and the University of Pennsylvania Health System, which together form a $7.8 billion enterprise.
The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according to U.S. News & World Report’s survey of research-oriented medical schools. The School is consistently among the nation’s top recipients of funding from the National Institutes of Health, with $425 million awarded in the 2018 fiscal year.
The University of Pennsylvania Health System’s patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center — which are recognized as one of the nation’s top “Honor Roll” hospitals by U.S. News & World Report — Chester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nation’s first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Home Care and Hospice Services, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.
Penn Medicine is powered by a talented and dedicated workforce of more than 40,000 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.
Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2018, Penn Medicine provided more than $525 million to benefit our community.